NCT03232008

Brief Summary

This study investigates the effects of Canderel, an aspartame and acesulfame-k blend artificial sweetener powder, on post-postprandial blood glucose levels and appetite scores.

Trial Health

43
At Risk

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Trial has exceeded expected completion date
Enrollment
110

participants targeted

Target at P50-P75 for not_applicable

Timeline
Completed

Started Sep 2015

Longer than P75 for not_applicable

Geographic Reach
1 country

1 active site

Status
unknown

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Start

First participant enrolled

September 1, 2015

Completed
1.8 years until next milestone

First Submitted

Initial submission to the registry

June 19, 2017

Completed
1 month until next milestone

First Posted

Study publicly available on registry

July 27, 2017

Completed
1.6 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

February 28, 2019

Completed
2.1 years until next milestone

Study Completion

Last participant's last visit for all outcomes

March 28, 2021

Completed
Last Updated

September 22, 2020

Status Verified

September 1, 2020

Enrollment Period

3.5 years

First QC Date

June 19, 2017

Last Update Submit

September 21, 2020

Conditions

Appetitive BehaviorGlucose Metabolism Disorders

Keywords

Blood glucoseAppetite

Outcome Measures

Primary Outcomes (2)

  • Change in Blood glucose

    Capillary blood obtained from fingerprick and measured using glucose monitor

    0-180min (Measured from baseline to 90min every 15min; 90-180min every 30min)

  • Change in Appetite

    Feelings of hunger, desire to eat, fullness and alertness measured using Visual Analog Scale (VAS)

    0-180min (Measured from baseline to 90min every 15min; 90-180min every 30min)

Study Arms (4)

Experiment A- experimental

EXPERIMENTAL

3g Canderel in 250ml water

Dietary Supplement: Canderel drink

Experiment A- control

NO INTERVENTION

3g of maltodextrin in 250 ml of water

Experiment B- experimental

EXPERIMENTAL

3g Canderel + 35g Lyle's Golden Syrup in 250 ml water

Dietary Supplement: Canderel+Lyle's Golden Syrup drink

Experiment B- control

NO INTERVENTION

3g Lyle's Golden Syrup + 35g of maltodextrin in 250 ml of water

Interventions

Canderel drinkDIETARY_SUPPLEMENT

1.4% aspartame and 0.95% acesulfame-k and 95% maltodextrin; 3g dissolved in 250ml of water

Experiment A- experimental
Canderel+Lyle's Golden Syrup drinkDIETARY_SUPPLEMENT

Canderel: 1.4% aspartame and 0.95% acesulfame-k and 95% maltodextrin; 3g dissolved in 250ml of water Lyle's Golden Syrup: 35 g (27g of glucose and fructose)

Experiment B- experimental

Eligibility Criteria

Age18 Years - 64 Years
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64)

You may qualify if:

  • Healthy male and female adults (18-64)

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

King's College London

London, SE1 9NH, United Kingdom

Location

MeSH Terms

Conditions

Appetitive BehaviorGlucose Metabolism Disorders

Condition Hierarchy (Ancestors)

Behavior, AnimalBehaviorMetabolic DiseasesNutritional and Metabolic Diseases

Study Officials

  • Dr. Christopher Corpe

    King's College London

    PRINCIPAL INVESTIGATOR

Study Design

Study Type
interventional
Phase
not applicable
Allocation
RANDOMIZED
Masking
QUADRUPLE
Who Masked
PARTICIPANT, CARE PROVIDER, INVESTIGATOR, OUTCOMES ASSESSOR
Purpose
BASIC SCIENCE
Intervention Model
PARALLEL
Sponsor Type
OTHER
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
Nutrition Sciences Lecturer, Principal investigator

Study Record Dates

First Submitted

June 19, 2017

First Posted

July 27, 2017

Study Start

September 1, 2015

Primary Completion

February 28, 2019

Study Completion

March 28, 2021

Last Updated

September 22, 2020

Record last verified: 2020-09

Data Sharing

IPD Sharing
Will not share

Locations

GB(1)