Effect of Exercise on Appetite, Gut Peptides and Butyrylcholinesterase Activity in Variants of the FTO Gene
1 other identifier
interventional
24
1 country
1
Brief Summary
Using a database of individuals with FTO genetic data, the study aims to assess the appetite, energy intake, butyrylcholinesterase, gut hormone responses to a bout of moderate- to high intensity exercise in individuals with genetic variations in the FTO gene.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at below P25 for not_applicable
Started Dec 2014
Typical duration for not_applicable
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
Click on a node to explore related trials.
Study Timeline
Key milestones and dates
Study Start
First participant enrolled
December 1, 2014
CompletedPrimary Completion
Last participant's last visit for primary outcome
December 1, 2016
CompletedStudy Completion
Last participant's last visit for all outcomes
December 1, 2016
CompletedFirst Submitted
Initial submission to the registry
January 17, 2017
CompletedFirst Posted
Study publicly available on registry
January 19, 2017
CompletedFebruary 7, 2019
February 1, 2019
2 years
January 17, 2017
February 5, 2019
Conditions
Outcome Measures
Primary Outcomes (5)
Plasma acylated ghrelin concentrations (N=24)
Measured using ELISA from venous blood samples
24 hours
Plasma desacyl ghrelin concentrations (N=24)
Measured using ELISA from venous blood samples
24 hours
Subjective appetite (N=24)
Measured using visual analogue scales
24 hours
Ad-libitum energy intake (N=24)
Measured at laboratory-based meals
24 hours
Plasma butyrylcholinesterase activity (N=24)
Measured using Ellman's reagent protocol
First hour of main trial (three samples).
Secondary Outcomes (3)
Plasma total glucagon-like peptide 1 concentrations (N=24)
24 hours
Plasma total peptide yy concentrations (N=24)
24 hours
Plasma leptin concentrations (N=24)
Baseline (fasting) sample
Study Arms (2)
Control
EXPERIMENTALExperimental day where participants rest.
Exercise
EXPERIMENTALExperimental day where participants complete a run.
Interventions
Eligibility Criteria
You may qualify if:
- non-smoker, not currently dieting, weight stable for \>3 months (self-reported), no personal history of cardiovascular disease, metabolic disease or dyslipidaemia, European ancestry, no psychiatric or medical condition
You may not qualify if:
- food allergies, dislike or intolerance of study foods and drinks, irregular eating patterns, use of medication that could influence hormone concentrations
Contact the study team to confirm eligibility.
Sponsors & Collaborators
- Loughborough Universitylead
- University College, Londoncollaborator
- Rosetrees Trustcollaborator
- National Institute for Health Research, United Kingdomcollaborator
Study Sites (1)
Loughborough University
Loughborough, LE11 3TU, United Kingdom
Related Publications (4)
Frayling TM, Timpson NJ, Weedon MN, Zeggini E, Freathy RM, Lindgren CM, Perry JR, Elliott KS, Lango H, Rayner NW, Shields B, Harries LW, Barrett JC, Ellard S, Groves CJ, Knight B, Patch AM, Ness AR, Ebrahim S, Lawlor DA, Ring SM, Ben-Shlomo Y, Jarvelin MR, Sovio U, Bennett AJ, Melzer D, Ferrucci L, Loos RJ, Barroso I, Wareham NJ, Karpe F, Owen KR, Cardon LR, Walker M, Hitman GA, Palmer CN, Doney AS, Morris AD, Smith GD, Hattersley AT, McCarthy MI. A common variant in the FTO gene is associated with body mass index and predisposes to childhood and adult obesity. Science. 2007 May 11;316(5826):889-94. doi: 10.1126/science.1141634. Epub 2007 Apr 12.
PMID: 17434869BACKGROUNDSpeakman JR, Rance KA, Johnstone AM. Polymorphisms of the FTO gene are associated with variation in energy intake, but not energy expenditure. Obesity (Silver Spring). 2008 Aug;16(8):1961-5. doi: 10.1038/oby.2008.318. Epub 2008 Jun 12.
PMID: 18551109BACKGROUNDKarra E, O'Daly OG, Choudhury AI, Yousseif A, Millership S, Neary MT, Scott WR, Chandarana K, Manning S, Hess ME, Iwakura H, Akamizu T, Millet Q, Gelegen C, Drew ME, Rahman S, Emmanuel JJ, Williams SC, Ruther UU, Bruning JC, Withers DJ, Zelaya FO, Batterham RL. A link between FTO, ghrelin, and impaired brain food-cue responsivity. J Clin Invest. 2013 Aug;123(8):3539-51. doi: 10.1172/JCI44403. Epub 2013 Jul 15.
PMID: 23867619BACKGROUNDDorling JL, Clayton DJ, Jones J, Carter WG, Thackray AE, King JA, Pucci A, Batterham RL, Stensel DJ. A randomized crossover trial assessing the effects of acute exercise on appetite, circulating ghrelin concentrations, and butyrylcholinesterase activity in normal-weight males with variants of the obesity-linked FTO rs9939609 polymorphism. Am J Clin Nutr. 2019 Nov 1;110(5):1055-1066. doi: 10.1093/ajcn/nqz188.
PMID: 31504106DERIVED
MeSH Terms
Conditions
Interventions
Condition Hierarchy (Ancestors)
Intervention Hierarchy (Ancestors)
Study Officials
- PRINCIPAL INVESTIGATOR
David J Stensel, PhD
Loughborough University
Study Design
- Study Type
- interventional
- Phase
- not applicable
- Allocation
- RANDOMIZED
- Masking
- NONE
- Purpose
- BASIC SCIENCE
- Intervention Model
- CROSSOVER
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- Professor of Exercise Metabolism
Study Record Dates
First Submitted
January 17, 2017
First Posted
January 19, 2017
Study Start
December 1, 2014
Primary Completion
December 1, 2016
Study Completion
December 1, 2016
Last Updated
February 7, 2019
Record last verified: 2019-02
Data Sharing
- IPD Sharing
- Will not share