The Ma'Anshan Birth Cohort (MABC)

NCT03215368 | Active Not Recruiting

• 1 other identifier: 20131195
• Study Type: observational
• Target: 3,474
• Locations: 1 country
• Sites: 1

Brief Summary

The Ma'anshan Birth Cohort (MABC) is a population-based prospective pregnancy and birth cohort study that aims to explore the early environmental and genetic determinants of maternal and child health, with a focus on health outcomes including maternal health, children's cognitive and behavioral development, growth and physical development, video-screen behaviors, and asthma and allergic diseases. MABC was officially launched in May 2013 at the Ma'anshan Maternal and Child Health Hospital in Anhui Province, and a total of 3,474 families were recruited as of September 2014 to continuously track the health status of mother-child pairs during pregnancy, delivery, and childhood, including basic family demographics, maternal pregnancy and birth history and past history, history of exposure to hazardous factors during pregnancy, children's diets and lifestyles, and children's physical and cognitive-behavioral development, MABC quantifies the attributional relationship between environmental chemicals, diet and nutrition, drug safety, psychological stress, lifestyle, biorhythm, endocrine metabolism and adverse birth outcomes, birth defects, neurodevelopmental disorders, developmental disabilities, etc., and identifies environmental, behavioral and genetic causative factors for birth defects and common developmental disorders, and identifies early warning signs and symptoms for early detection of birth defects. genetic causative factors, identify clinical biomarkers with early predictive effects, integrate and form a precise risk evaluation and early warning model, carry out regional comprehensive prevention and treatment applications, and promote the improvement of the quality of the birth population. Currently, MABC is conducting its 20th school-age follow-up visit.

Conditions

Environmental Exposure; Pregnancy Outcome; Birth Defects; Child Development; Maternal and Child Health; Health Problems in Pregnancy

Keywords

birth cohort study; environmental exposures; birth defects; pregnant outcomes; children development; Maternal and child health

Outcome Measures

Primary Outcomes (2)

• Numbers of participants with pregnancy complications

  Including gestational diabetes, gestational hypertension, anemia, and hypothyroidism during pregnancy. Diagnosis by medical personnel at clinics

  At delivery

• Numbers of participants with adverse pregnancy outcomes

  Including preterm birth, low birth weight, macrosomia, abortion, stillbirth, and birth defects. Hospital information system collection

  At delivery

Secondary Outcomes (9)

• Weight in kilogram changes during childhood

  At birth and age at 42 days, 3 months, 6 months, 9 months, 1 year, 1.5 years, 2 years, 2.5 years, 3 years, 3.5 years, 4 years, 4.5years, 5 years, 6 years, 7 years, 8 years, 9 years, 10 years, 11years and 12 years

• Height in centimeter changes during childhood

  At birth and age at 42 days, 3 months, 6 months, 9 months, 1 year, 1.5 years, 2 years, 2.5 years, 3 years, 3.5 years, 4 years, 4.5years, 5 years, 6 years, 7 years, 8 years, 9 years, 10 years, 11years and 12 years

• Early Child development

  Age at 6 months, 48 months and 54 months

• Child Psychological and Behavioural Development

  Age at 48 months, 60 months and 72 months

• Child Intelligence quotient

  At age of 54 months

Eligibility Criteria

• Age: 18 Years - 44 Years
• Sex: female
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)
• Sampling Method: Non-Probability Sample

Study Population

From May 2013 to September 2014, 3474 pregnant women who first established a maternal health handbook in Ma'anshan Maternal and Child Health Hospital (MCHH) and were willing to undergo regular obstetric checkups and deliveries in the hospital were selected for inclusion in the cohort.

You may qualify if:

• Permanent residents of Ma'anshan city;
• Obstetric examination and delivery at Ma'anshan Maternal and Child Health Hospital;
• Mother's age ≥ 18 years old and gestational week ≤ 14 weeks;
• No serious neuropsychiatric disorders, with sufficient understanding and expression to complete the survey.

You may not qualify if:

• Intellectual disability or other serious mental disorders;
• Suffering from serious underlying diseases and may have a significant impact on pregnancy outcome;
• Those with poor compliance and difficulty in follow-up.

Sponsors & Collaborators

• Anhui Medical University: lead
• Ma'anshan Maternal and Child Health Care Hospital: collaborator

Study Sites (1)

Ma'anshan Maternal and Child Health Care Hospital

Ma’anshan, Anhui, 243011, China

Location

Biospecimen

Retention: SAMPLES WITH DNA

Pregnancy and delivery：maternal blood, urine, cord blood and placenta. During infancy: urine and blood. During school age：Blood, urine and hair mother-child pairs

MeSH Terms

Conditions

Congenital Abnormalities

Condition Hierarchy (Ancestors)

Congenital, Hereditary, and Neonatal Diseases and Abnormalities

Study Officials

• Fangbiao Tao

  Anhui Medical University

  STUDY DIRECTOR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Principal Investigator

Study Record Dates

• First Submitted: July 6, 2017
• First Posted: July 12, 2017
• Study Start: May 16, 2013
• Primary Completion (Estimated): December 30, 2027
• Study Completion (Estimated): December 30, 2027
• Last Updated: April 12, 2024

Record last verified: 2024-04

Data Sharing

• IPD Sharing: Will not share

Locations

CN (1)