Evaluation of the Pattern of Thyroid Dysfunctions in Patients With Metabolic Syndrome

NCT03214068 | Completed

• 1 other identifier: 17100051
• Study Type: observational
• Target: 200
• Locations: 1 country
• Sites: 1

Brief Summary

The study on evaluation the pattern of TD in MetS population may help us to know the magnitude of overlap of these two disease entities and may highlight the importance of thyroid function tests in patients with MetS. This can lead to proper planning and adequate management strategies, resulting in significant reduction in cardiovascular morbidity and mortality due to MetS with TD. Thus, this study aims to evaluate the pattern of TD in patients with MetS and to explore the relationship between TD and components of the MetS.

Conditions

Metabolic Syndrome

Outcome Measures

Primary Outcomes (1)

• Thyroid stimulating hormone

  Evaluation of thyroid dysfunctions in patients with metabolic syndrome

  2 years.

Secondary Outcomes (1)

• Lipid profile

  2 years

Eligibility Criteria

• Age: 20 Years - 70 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

The study will include 100 patients with metabolic syndrome (MetS) who fulfilled criteria according to the 2005 Revised National Cholesterol Education Program/ATP III. Age and sex matched100 healthy persons who have no features of metabolic syndrome will be included in the study as a control group .

You may qualify if:

• Patients satisfying the 2005 Revised National Cholesterol Education Program/AdenosineTri Phosphate III which have three out of five of the following criteria:
• Central obesity - defined as waist circumference ≥102 cm for Men and ≥88cm for women.
• Raised triglycerides: ≥ 150 mg/dL, or specific treatment for this lipid abnormality.
• Reduced HDL cholesterol: \< 40 mg/dL in males,\< 50 mg/dL in females, or specific treatment for this lipid abnormality
• Raised blood pressure: systolic BP ≥130 or diastolic BP ≥85 mm Hg, or treatment of previously diagnosed hypertension.
• Raised fasting plasma glucose :( FPG) ≥100 mg /dL, or previously diagnosed type 2 diabetes.
• knownly diagnosed diabetes mellitus .
• hypertension diagnosed patients .
• obese patients.

You may not qualify if:

• \. Patients with liver disorders, renal disorders, congestive cardiac failure, pregnant women.
• \. Patients with history of respiratory disease, malignancy, Smokers, alcoholics, 4. patients receiving medication that may alter thyroid functions or lipid levels,

Sponsors & Collaborators

• Assiut University: lead

Study Sites (1)

Medicine

Asyut, Egypt

Location

Related Publications (1)

• Udenze I, Nnaji I, Oshodi T. Thyroid function in adult Nigerians with metabolic syndrome. Pan Afr Med J. 2014 Aug 29;18:352. doi: 10.11604/pamj.2014.18.352.4551. eCollection 2014.

  PMID: 25574328 RESULT

Related Links

• Thyroid function in adult Nigerians with metabolic syndrome

MeSH Terms

Conditions

Metabolic Syndrome

Condition Hierarchy (Ancestors)

Insulin Resistance; Hyperinsulinism; Glucose Metabolism Disorders; Metabolic Diseases; Nutritional and Metabolic Diseases

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: OTHER
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Resident doctor of internal medicine

Study Record Dates

• First Submitted: July 6, 2017
• First Posted: July 11, 2017
• Study Start: July 5, 2018
• Primary Completion: September 5, 2018
• Study Completion: December 5, 2018
• Last Updated: May 5, 2020

Record last verified: 2020-05

Data Sharing

• IPD Sharing: Will not share

Locations

EG (1)