Prospective Observation for Serial Changes in Acute Intracranial Artery Dissection Using HR-MRI

NCT03213470 | Completed

• 1 other identifier: ICD_01
• Study Type: interventional
• Target: 20
• Locations: 1 country
• Sites: 1

Brief Summary

Intracranial artery disease has been more detected with development of HR-MR. HR-MR can depict vascular wall directly and give us more information beyond the pre-existing imaging modalities such as digital subtraction angiography, magnetic resonance angiography, computed tomography angiography. Hence, HR-MR is considered to become promising imaging modality for intracranial artery disease and many studies have been published recently. However, there was not enough to differentiate various intracranial artery disease such as atherosclerosis, dissection, moyamoya disease, vasculitis, reversible vasoconstriction syndrome. In real clinical arena, intracranial artery disease is too difficult to diagnose and distinguish among the disease. Of the disease, usefulness of HR-MR has been consistently published in the detection and diagnosis of intracranial artery dissection recently. HR-MR seems to be the most important and reliable imaging method in intracranial artery dissection as of now. Therefore, intracranial artery dissection is necessary to study using HR-MR. Intracranial artery dissection is dynamic vascular pathology. The geometric change is the most common among intracranial artery disease. However, there was no report about the geometric change in HR-MR. The investigators acquired retrospective data about the natural course of intracranial artery dissection in HR-MR and are preparing for publishing an article. However, the data is not prospective and not intraindividual comparison. Therefore, reliability is not enough to convince the natural course. If the investigators got prospective and intraindividual data, definite natural course of intracranial artery dissection could be acquired and would be helpful to diagnose the dissection and differentiate from other vascular pathologies. The longitudinal information from this study could guide us as the important map on the confusing HR-MR findings. In addition, the previous retrospective study can be a stepping-stone to perform a prospective study, which can increase the success rate of the prospective study. The protocols for imaging follow-up are as followed: initial (optional), 1 month, 3 month, 6 month (optional), 12 month

Conditions

Cerebral Arteries; Dissection

Outcome Measures

Primary Outcomes (1)

• Prospective observation for serial changes in acute intracranial artery dissection using HR-MRI

  Radiological findings of HR-MRI during the study period

  The time interval from initial event to outcome measurement is 1 year.

Study Arms (1)

Intracranial artery dissection

OTHER

Patients with intracranial artery dissection who were diagnosed based on the clinical and radiological (including MRI) diagnoses at the symptom onset after Jan-01-2016

Other: magnetic resonance imaging

Interventions

magnetic resonance imaging OTHER

Intracranial artery dissection

Eligibility Criteria

• Sex: all
• Healthy Volunteers: No
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)

You may qualify if:

• Informed consent
• Acute intracranial artery dissection

You may not qualify if:

• angioplasty, or stenting,
• contraindication for MR imaging,
• Hypersensitivity to gadolinium based contrast media,
• Pregnant or lactating women,
• Renal condition : eGFR \< 60, 6) Patients unable and/or unwilling to comply with treatment or study instructions

Sponsors & Collaborators

• Asan Medical Center: lead
• Ministry of Health & Welfare, Korea: collaborator
• Bracco Corporate: collaborator

Study Sites (1)

Asan Medical Center

Seoul, 138-736, South Korea

Location

Related Publications (2)

• Park KJ, Jung SC, Kim HS, Choi CG, Kim SJ, Lee DH, Suh DC, Kwon SU, Kang DW, Kim JS. Multi-Contrast High-Resolution Magnetic Resonance Findings of Spontaneous and Unruptured Intracranial Vertebral Artery Dissection: Qualitative and Quantitative Analysis According to Stages. Cerebrovasc Dis. 2016;42(1-2):23-31. doi: 10.1159/000444315. Epub 2016 Mar 8.

  PMID: 26950228 RESULT

• Jeong SY, Jung SC, Roh YH, Kwon SU, Kang DW, Kim JS, Choi KM, Kim S, Jeong E. Serial changes and optimal imaging windows in vessel wall MRI for unruptured intracranial artery dissection. Sci Rep. 2025 Jul 1;15(1):21864. doi: 10.1038/s41598-025-05732-4.

  PMID: 40596300 DERIVED

MeSH Terms

Interventions

Magnetic Resonance Spectroscopy

Intervention Hierarchy (Ancestors)

Spectrum Analysis; Chemistry Techniques, Analytical; Investigative Techniques

Study Officials

• Seung Chai Jung, Professor

  Associate professor, Department of Radiology

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NA
• Masking: NONE
• Purpose: DIAGNOSTIC
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: MD. PhD.

Study Record Dates

• First Submitted: July 7, 2017
• First Posted: July 11, 2017
• Study Start: January 1, 2016
• Primary Completion: April 7, 2019
• Study Completion: April 7, 2019
• Last Updated: December 20, 2019

Record last verified: 2019-12

Locations

KR (1)