NCT07540429

Brief Summary

Impaired social cognition and cognitive control associated with borderline personality disorder (BPD) remain less explored. Recent Franco-Canadian study, has shown the feasibility of a neuroimaging tests in Quebec adolescents with BPD. This study aims to increase knowledgements related to neural correlates of BPD and clinical disorders.

Trial Health

77
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
21

participants targeted

Target at below P25 for not_applicable

Timeline
20mo left

Started Jun 2024

Longer than P75 for not_applicable

Geographic Reach
1 country

1 active site

Status
recruiting

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Progress54%
Jun 2024Dec 2027

Study Start

First participant enrolled

June 8, 2024

Completed
1.7 years until next milestone

First Submitted

Initial submission to the registry

February 18, 2026

Completed
2 months until next milestone

First Posted

Study publicly available on registry

April 20, 2026

Completed
1.1 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

June 8, 2027

Expected
7 months until next milestone

Study Completion

Last participant's last visit for all outcomes

December 31, 2027

Last Updated

April 20, 2026

Status Verified

March 1, 2026

Enrollment Period

3 years

First QC Date

February 18, 2026

Last Update Submit

April 17, 2026

Conditions

Diagnosis of BPD Based on the DIB-R Clinical Interview for the BPD GroupDiagnosis of ADHD Using the KSADS-PL for the ADHD GroupAbsence of Pathology on the CBCL and Ab-DIB for the Healthy Control GroupAll Participants Were Euthymic at the Time of Task Administration

Keywords

disturbances in social cognitioncognitive control associatedborderline personality disorderneuroimaging in adolescent girlschild psychiatry

Outcome Measures

Primary Outcomes (1)

  • MRI-Acquired Activation Mapping

    Establishment of activation maps by statistical analysis of local signal variations to locate functional regions essential to motor skills and language.

    2 years

Secondary Outcomes (1)

  • Feasibility of this study

    2 years

Study Arms (3)

Healthy adolescent girl volunteers

OTHER

The participants will follow the same study plan

Diagnostic Test: functional magnetic resonance imaging (fMRI)

Adolescent girls with borderline personality disorder

OTHER

The participants will follow the same study plan

Diagnostic Test: functional magnetic resonance imaging (fMRI)

Adolescent girls with Attention Deficit Hyperactivity Disorder

OTHER

The participants will follow the same study plan

Diagnostic Test: functional magnetic resonance imaging (fMRI)

Interventions

functional magnetic resonance imaging (fMRI)DIAGNOSTIC_TEST

Investigators used fMRI to compare patterns of regional brain activation between three groups of adolescents girls: Six female adolescents meeting criteria for BPD, 6 female adolescents meeting criteria of ADHD and 6 female adolescents without psychiatric disorder were recruited.

Adolescent girls with Attention Deficit Hyperactivity DisorderAdolescent girls with borderline personality disorderHealthy adolescent girl volunteers

Eligibility Criteria

Age12 Years - 17 Years
Sexfemale
Healthy VolunteersYes
Age GroupsChild (0-17)

You may qualify if:

  • Female adolescents meeting DIB-R criteria for BPD group
  • Female adolescents meeting kSADS-PL for ADHD group
  • Female adolescents without any psychologic disorders

You may not qualify if:

  • Any medical history with head trauma, chronic neurologic disease, any contraindications for fRMI, claustrophobia or pregnancy.

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

EPSM de la Somme

Dury, 80480, France

RECRUITING

Related Publications (1)

  • Guile JM, Boissel L, Alaux-Cantin S, de La Riviere SG. Borderline personality disorder in adolescents: prevalence, diagnosis, and treatment strategies. Adolesc Health Med Ther. 2018 Nov 23;9:199-210. doi: 10.2147/AHMT.S156565. eCollection 2018.

    PMID: 30538595BACKGROUND

MeSH Terms

Conditions

Borderline Personality Disorder

Interventions

Magnetic Resonance Imaging

Condition Hierarchy (Ancestors)

Personality DisordersMental Disorders

Intervention Hierarchy (Ancestors)

TomographyDiagnostic ImagingDiagnostic Techniques and ProceduresDiagnosis

Study Officials

  • Jean Marc GUILE, Professor

    EPSM de la Somme

    PRINCIPAL INVESTIGATOR

Central Study Contacts

MICHAEL MONET, PhD

CONTACT

0322534612unite.2.recherche@epsm-somme.fr

Jean Marc GUILE, Professor

CONTACT

jmguile@gmail.com

Study Design

Study Type
interventional
Phase
not applicable
Allocation
NON RANDOMIZED
Masking
SINGLE
Who Masked
PARTICIPANT
Purpose
DIAGNOSTIC
Intervention Model
PARALLEL
Sponsor Type
NETWORK
Responsible Party
SPONSOR

Study Record Dates

First Submitted

February 18, 2026

First Posted

April 20, 2026

Study Start

June 8, 2024

Primary Completion (Estimated)

June 8, 2027

Study Completion (Estimated)

December 31, 2027

Last Updated

April 20, 2026

Record last verified: 2026-03

Locations

FR(1)