Visual Information Processing in Schizophrenia Patients With Visual Hallucinations

NCT03188133 | Unknown DMC

• 1 other identifier: ID-RCB/2017-A01058-45
• Study Type: interventional
• Target: 90
• Locations: 0 countries
• Sites: N/A

Brief Summary

Occurrence of visual hallucinations (VHs) in schizophrenia depend in part on disorders in the processing of late visual information (Top-Down). The broader question of how these top-down mechanisms (cognitive and / or emotional mechanisms) are involved in the occurrence of VHs remains to be specified and very few behavioral studies have so far been interested. The investigators propose to study the implication of Top-Down mechanisms in the visual hallucinatory manifestations, more specifically in the processing of ambiguous stimuli during an emotional priming task. Schizophrenia patients with VHs would have more false visual perceptions in the treatment of ambiguous stimuli than schizophrenia patients with auditory hallucinations or no hallucinations (AH/NH) and healthy controls.

Conditions

Schizophrenia; Visual Hallucination; Auditory Hallucination; False Perception

Keywords

Schizophrenia; Visual Hallucination; False Perception; emotional priming

Outcome Measures

Primary Outcomes (1)

• Number of false visual perception on the emotional priming task

  Number of false perception made by participants on an ambiguous visual stimulus i.e when a participant identifies incorrectly an ambiguous stimulus as a genuine percept (for example a participant sees a face in a noisy grey pattern)

  through study completion an average of 6 months

Secondary Outcomes (3)

• number of false visual perception on the emotional priming task depending of the emotional valence manipulated

  through study completion an average of 6 months

• Cognitive performances at the neuropsychological assessment

  through study completion an average of 6 months

• Psychosensory hallucinations scale scores

  through study completion an average of 6 months

Study Arms (3)

VH

EXPERIMENTAL

schizophrenia patients with visual hallucinations

Other: behavioral task : emotional priming

AH/NH

ACTIVE COMPARATOR

schizophrenia patients with auditory hallucinations or no hallucinations

Other: behavioral task : emotional priming

C

ACTIVE COMPARATOR

healthy controls

Other: behavioral task : emotional priming

Interventions

behavioral task : emotional priming OTHER

emotional priming task on ambiguous visual stimuli

AH/NH; C; VH

Eligibility Criteria

• Age: 18 Years - 55 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

All Groups: * Age between 18 and 55 years * Affiliation to or benefiting from a social security * Visual acuity normal or corrected to normal * Person who received and understood the complete information about the organization of the research and gave written and free informed consent before participating in the study Group of patients with schizophrenia with visual hallucination (HV) with or without auditory hallucination (HA) (HV group): * Schizophrenia according to the Diagnostic and Statistical Manual of Mental Disorders IV criteria * Presence of a hallucinatory visual symptomatology (HV) in the history of the disease measured by the Psychosensory hallucination scale (PSAS). * The presence of a hallucinatory symptomatology in auditory mode (HA) in addition to the HV is not a criterion of non-inclusion. Group of patients with schizophrenia either with auditory hallucination (HA) but without visual hallucination (HV) or no hallucination, auditory or visual (NH) (HA / NH group) * Schizophrenia according to the Diagnostic and Statistical Manual of Mental Disorders IV criteria * Presence of a hallucinatory symptomatology in auditory mode (HA) in the history of the disease measured by the PSAS or absence of any hallucinatory manifestations in the history of the disease * Absence of visual hallucinatory symptomatology (HV) in the history of the disease as measured by PSAS

Contact the study team to discuss eligibility requirements. They can help determine if this study is right for you.

Sponsors & Collaborators

• Central Hospital, Nancy, France: lead

Related Publications (4)

• Catalan A, Simons CJ, Bustamante S, Drukker M, Madrazo A, de Artaza MG, Gorostiza I, van Os J, Gonzalez-Torres MA. Novel evidence that attributing affectively salient signal to random noise is associated with psychosis. PLoS One. 2014 Jul 14;9(7):e102520. doi: 10.1371/journal.pone.0102520. eCollection 2014.

  PMID: 25020079 BACKGROUND

• Hoffman RE, Woods SW, Hawkins KA, Pittman B, Tohen M, Preda A, Breier A, Glist J, Addington J, Perkins DO, McGlashan TH. Extracting spurious messages from noise and risk of schizophrenia-spectrum disorders in a prodromal population. Br J Psychiatry. 2007 Oct;191:355-6. doi: 10.1192/bjp.bp.106.031195.

  PMID: 17906248 BACKGROUND

• Galdos M, Simons C, Fernandez-Rivas A, Wichers M, Peralta C, Lataster T, Amer G, Myin-Germeys I, Allardyce J, Gonzalez-Torres MA, van Os J. Affectively salient meaning in random noise: a task sensitive to psychosis liability. Schizophr Bull. 2011 Nov;37(6):1179-86. doi: 10.1093/schbul/sbq029. Epub 2010 Apr 1.

  PMID: 20360211 BACKGROUND

• Hooker CI, Tully LM, Verosky SC, Fisher M, Holland C, Vinogradov S. Can I trust you? Negative affective priming influences social judgments in schizophrenia. J Abnorm Psychol. 2011 Feb;120(1):98-107. doi: 10.1037/a0020630.

  PMID: 20919787 BACKGROUND

MeSH Terms

Conditions

Schizophrenia; Hallucinations

Condition Hierarchy (Ancestors)

Schizophrenia Spectrum and Other Psychotic Disorders; Mental Disorders; Perceptual Disorders; Neurobehavioral Manifestations; Neurologic Manifestations; Nervous System Diseases; Signs and Symptoms; Pathological Conditions, Signs and Symptoms

Study Officials

• Vincent LAPREVOTE

  Central hospital Nancy, Centre Psychothérapique de Nancy

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Vincent LAPREVOTE

CONTACT

0033+383926822; vincent.laprevote@cpn-laxou.com

Florent BERNARDIN

CONTACT

0033+383925034; florent.bernardin@cpn-laxou.com

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NON RANDOMIZED
• Masking: NONE
• Purpose: BASIC SCIENCE
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: June 9, 2017
• First Posted: June 15, 2017
• Study Start: October 17, 2017
• Primary Completion: May 1, 2018
• Study Completion: October 31, 2020
• Last Updated: October 9, 2017

Record last verified: 2017-10

Data Sharing

• IPD Sharing: Will not share