Impact of HMGB1 on Diastolic Dysfunction in Hypertensive Patients
1 other identifier
observational
100
0 countries
N/A
Brief Summary
This study evaluated the association between HMGB1 and diastolic dysfunction in hypertensive patients. HMGB1 level were tested in all patients, and diastolic function determined by echocardiographic.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P50-P75 for all trials
Started Aug 2017
Shorter than P25 for all trials
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
First Submitted
Initial submission to the registry
April 16, 2017
CompletedFirst Posted
Study publicly available on registry
June 6, 2017
CompletedStudy Start
First participant enrolled
August 15, 2017
CompletedPrimary Completion
Last participant's last visit for primary outcome
December 31, 2017
CompletedStudy Completion
Last participant's last visit for all outcomes
December 31, 2017
CompletedJune 6, 2017
June 1, 2017
5 months
April 16, 2017
June 4, 2017
Conditions
Keywords
Outcome Measures
Primary Outcomes (1)
Differences of HMGB1 levels between hypertensive patients with and without diastolic dysfunction
Blood samples of all individuals are collected on the day of admission and HMGB1 levels are tested. Echocardiographic assessment is performed with echocardiography device by using 2.5-3.5 Mega Hertz(MHz) transducer in the lateral decubitis position.
on the day of admission
Secondary Outcomes (1)
Differences of HMGB1 levels between grades of diastolic dysfunction
on the day of admission
Eligibility Criteria
The study sample is recruited from the patients examined in the physical examination center of our hospital.
You may qualify if:
- All of the hypertensive patients in both diastolic dysfunction and control groups were either newly diagnosed or were aware of hypertension without using any pharmacotherapy.
You may not qualify if:
- Individuals already under treatment for hypertension were not include.
Contact the study team to confirm eligibility.
Sponsors & Collaborators
- Jing Lilead
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Study Design
- Study Type
- observational
- Observational Model
- CASE CONTROL
- Time Perspective
- PROSPECTIVE
- Sponsor Type
- OTHER
- Responsible Party
- SPONSOR INVESTIGATOR
- PI Title
- Doctor
Study Record Dates
First Submitted
April 16, 2017
First Posted
June 6, 2017
Study Start
August 15, 2017
Primary Completion
December 31, 2017
Study Completion
December 31, 2017
Last Updated
June 6, 2017
Record last verified: 2017-06
Data Sharing
- IPD Sharing
- Will not share