Fish, Polyunsaturated Fatty Acids Intake and Mortality

NCT03155659 | Completed

• 1 other identifier: Cohort_PUFA
• Study Type: observational
• Target: 50,145
• Locations: 0 countries
• Sites: N/A

Brief Summary

Data linking fish, polyunsaturated fatty acids intake and mortality are lacking and conflicting. We aim to use data from the China Health and Nutrition Survey (CHNS) and National Health and Nutrition Examination Survey (NHANES) to investigate the associations of fish and polyunsaturated fatty acids (PUFA) intake with mortality in Chinese and US populations. The study findings will be informative for addressing the role of fish and specific PUFA in human health and improve basis for dietary recommendations.

Conditions

Polyunsaturated Fatty Acids; Mortality

Keywords

Fish; Polyunsaturated fatty acids; Mortality; CHNS; NHANES

Outcome Measures

Primary Outcomes (1)

• Total Mortality

  Total Mortality from All Causes

  From baseline until death or censoring on 31 December 2011, whichever came first, assessed up to an average of 10 years

Secondary Outcomes (1)

• Cause-specific mortality

  From baseline until death or censoring on 31 December 2011, whichever came first, assessed up to an average of 10 years

Eligibility Criteria

• Age: 20 Years+
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

CHNS is an ongoing, large-scale, household-based cohort starting in 1989. The survey used a multi-stage, random cluster process to draw a sample of 9 provinces and municipal cities, which take up about half of Chinese population. NHANES is also a nationally-representative study of nutrition and health for individuals residing in the U.S. Our study included participants in CHNS and NHANES who met the eligibility criteria.

You may qualify if:

• Adults aged ≥20 with complete data on diet and follow-up time

You may not qualify if:

• Missing information for mortality
• Cardiovascular disease
• Cancer

Sponsors & Collaborators

• Zhejiang University: lead
• National Institute of Health and Nutrition: collaborator

Related Publications (3)

• Zhao LG, Sun JW, Yang Y, Ma X, Wang YY, Xiang YB. Fish consumption and all-cause mortality: a meta-analysis of cohort studies. Eur J Clin Nutr. 2016 Feb;70(2):155-61. doi: 10.1038/ejcn.2015.72. Epub 2015 May 13.

  PMID: 25969396 RESULT

• Rizos EC, Ntzani EE, Bika E, Kostapanos MS, Elisaf MS. Association between omega-3 fatty acid supplementation and risk of major cardiovascular disease events: a systematic review and meta-analysis. JAMA. 2012 Sep 12;308(10):1024-33. doi: 10.1001/2012.jama.11374.

  PMID: 22968891 RESULT

• Zhuang P, Wang W, Wang J, Zhang Y, Jiao J. Polyunsaturated fatty acids intake, omega-6/omega-3 ratio and mortality: Findings from two independent nationwide cohorts. Clin Nutr. 2019 Apr;38(2):848-855. doi: 10.1016/j.clnu.2018.02.019. Epub 2018 Mar 3.

  PMID: 29551407 DERIVED

Related Links

• Related Info

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Associate Professor

Study Record Dates

• First Submitted: May 13, 2017
• First Posted: May 16, 2017
• Study Start: January 1, 1989
• Primary Completion: December 1, 2011
• Study Completion: July 1, 2012
• Last Updated: March 15, 2024

Record last verified: 2024-03