Does Oxytocin Modulate Rewarding Effects in Women and Fluctuating Across the Menstrual Cycle
1 other identifier
interventional
80
1 country
1
Brief Summary
The aim of the study is to explore how the rewarding effect of men's verbal compliment is modulated by oxytocin and gonadal hormone in a romantic context.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P75+ for early_phase_1 healthy
Started Oct 2016
Typical duration for early_phase_1 healthy
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
Study Start
First participant enrolled
October 1, 2016
CompletedFirst Submitted
Initial submission to the registry
May 4, 2017
CompletedFirst Posted
Study publicly available on registry
May 8, 2017
CompletedPrimary Completion
Last participant's last visit for primary outcome
June 1, 2018
CompletedStudy Completion
Last participant's last visit for all outcomes
July 1, 2018
CompletedOctober 29, 2018
October 1, 2018
1.7 years
May 4, 2017
October 26, 2018
Conditions
Keywords
Outcome Measures
Primary Outcomes (1)
Oxytocin effect on neural activity as assessed via fMRI towards reward between fertility and luteal phases
Effects of oxytocin versus placebo nasal spray on neural processing of reward will be compared between different cycle phases
45min-120min after treatment
Study Arms (4)
oxytocin fertility
EXPERIMENTALintranasal oxytocin administration (24IU) in women's fertility phase (LH\>40 mIU/ml)
placebos fertility
PLACEBO COMPARATORintranasal placebo administration (24IU) in women's fertility phase (LH\>40 mIU/ml)
oxytocin luteal
EXPERIMENTALintranasal oxytocin administration (24IU) in women's luteal phase (LH\<30 mIU/ml)
placebos luteal
PLACEBO COMPARATORintranasal placebos administration (24IU) in women's luteal phase (LH\<30 mIU/ml)
Interventions
Eligibility Criteria
You may qualify if:
- Single in the past 3 months
- Healthy subjects with regular menstrual cycle
You may not qualify if:
- Pregnant, menstruating, taking oral contraceptives
- metal implanted, with tatoo, or hair dyed within 6 months
- participated in another intranasal experiment within 6 months
- with a history of past or current psychiatric or neurological disorder
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
University of Electronic Science and Technology of Chia
Chengdu, Sichuan, 611731, China
Related Publications (1)
Gao Z, Ma X, Zhou X, Xin F, Gao S, Kou J, Becker B, Kendrick KM. Oxytocin Reduces the Attractiveness of Silver-Tongued Men for Women During Mid-Cycle. Front Neurosci. 2022 Apr 28;16:760695. doi: 10.3389/fnins.2022.760695. eCollection 2022.
PMID: 35573309DERIVED
MeSH Terms
Interventions
Intervention Hierarchy (Ancestors)
Study Officials
- PRINCIPAL INVESTIGATOR
Keith M Kendrick, Dr.
University of Electronic Science and Technology of China
Study Design
- Study Type
- interventional
- Phase
- early phase 1
- Allocation
- RANDOMIZED
- Masking
- DOUBLE
- Who Masked
- PARTICIPANT, INVESTIGATOR
- Purpose
- BASIC SCIENCE
- Intervention Model
- PARALLEL
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- Professor
Study Record Dates
First Submitted
May 4, 2017
First Posted
May 8, 2017
Study Start
October 1, 2016
Primary Completion
June 1, 2018
Study Completion
July 1, 2018
Last Updated
October 29, 2018
Record last verified: 2018-10