Predictive Role of Red Cell Distribution Width in Upper GI Bleeding Patients

NCT03119987 | Completed DMC

• 1 other identifier: RDWUGI
• Study Type: observational
• Target: 400
• Locations: 0 countries
• Sites: N/A

Brief Summary

Acute upper-gastrointestinal bleeding (UGIB) is a commonly encountered cause of admission in emergency department (ED). Early risk stratification allows appropriate therapy that may be helpful to advance the patient's morbidity and mortality. Investigators hypothesized that early RDW levels may have an independent, linear relationship with recurrent or massive bleeding in UGIB patients.

Conditions

Gastrointestinal Hemorrhage

Keywords

Red cell Distribution Width; Risk; Mortality; Hemorrhage

Outcome Measures

Primary Outcomes (1)

• High risk

  Case of the death or re-bleeding, or blood transfusion or endoscopic therapy or operation.

  30 days

Study Arms (1)

UGIB

Those who was diagnosed as UGI bleeding at emergency department during the study periods. Red cell distribution widths wers checked at all patients.

Diagnostic Test: Red cell distribution widths

Interventions

Red cell distribution widths DIAGNOSTIC_TEST

Measured value of Red cell distribution widths in initial laboratory result of blood cell counts at emergency department

UGIB

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Adult patients who visited to emergency department due to Upper gastrointestinal bleeding

You may qualify if:

• Age over 18 years
• Diagnosis as Upper gastrointestinal bleeding
• Check RDW when patients visited at emergency department

You may not qualify if:

• Paediatrics
• Follow up loss
• Data could not be acquired

Sponsors & Collaborators

• Konkuk University Medical Center: lead

Related Publications (4)

• Blatchford O, Murray WR, Blatchford M. A risk score to predict need for treatment for upper-gastrointestinal haemorrhage. Lancet. 2000 Oct 14;356(9238):1318-21. doi: 10.1016/S0140-6736(00)02816-6.

  PMID: 11073021 BACKGROUND

• van Kimmenade RR, Mohammed AA, Uthamalingam S, van der Meer P, Felker GM, Januzzi JL Jr. Red blood cell distribution width and 1-year mortality in acute heart failure. Eur J Heart Fail. 2010 Feb;12(2):129-36. doi: 10.1093/eurjhf/hfp179. Epub 2009 Dec 20.

  PMID: 20026456 BACKGROUND

• Masaoka T, Suzuki H, Hori S, Aikawa N, Hibi T. Blatchford scoring system is a useful scoring system for detecting patients with upper gastrointestinal bleeding who do not need endoscopic intervention. J Gastroenterol Hepatol. 2007 Sep;22(9):1404-8. doi: 10.1111/j.1440-1746.2006.04762.x.

  PMID: 17716345 BACKGROUND

• Stanley AJ, Ashley D, Dalton HR, Mowat C, Gaya DR, Thompson E, Warshow U, Groome M, Cahill A, Benson G, Blatchford O, Murray W. Outpatient management of patients with low-risk upper-gastrointestinal haemorrhage: multicentre validation and prospective evaluation. Lancet. 2009 Jan 3;373(9657):42-7. doi: 10.1016/S0140-6736(08)61769-9. Epub 2008 Dec 16.

  PMID: 19091393 BACKGROUND

MeSH Terms

Conditions

Gastrointestinal Hemorrhage; Hemorrhage

Condition Hierarchy (Ancestors)

Gastrointestinal Diseases; Digestive System Diseases; Pathologic Processes; Pathological Conditions, Signs and Symptoms

Study Officials

• Sang O Park, MD

  Department of Emergency Medicine, Konkuk University School of medicine

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Associate Professor

Study Record Dates

• First Submitted: April 14, 2017
• First Posted: April 19, 2017
• Study Start: January 1, 2011
• Primary Completion: December 30, 2012
• Study Completion: December 30, 2014
• Last Updated: March 7, 2018

Record last verified: 2018-03

Data Sharing

• IPD Sharing: Will not share