The Association Between Nephrolithiasis and Periodontal Status

NCT03102086 | Unknown

• 1 other identifier: 0097-16-RMB
• Study Type: observational
• Target: 20
• Locations: 1 country
• Sites: 1

Brief Summary

Dental calculus is a calcified deposits firmly attached to teeth and implants surfaces. Dental calculus is strongly associated with periodontitis and considered to have indirect role in the pathogenesis of periodontal diseases. Dental calculus composed primarily of calcium phosphate mineral salts originated in the saliva covered by unmineralized bacterial layer. Composition of calculus varies from person to person and influenced by numerous variables such as: age, gender systemic disease and ethnic background. Nephrolithiasis (kidney stones) are composed of insoluble salts of constituents of the forming urine. The most two frequent stone types are: Calcium oxalate (with a frequency of 15% -35%) and Calcium phosphate (5% -20%). The prevalence of kidney stones varies with race, sex, and geographic location. In the United States for men, kidney stone rates vary between 4%-9%, and for women, kidney stone rates range between 2%-4%. Previous studies dealt with the connection between sialolithiasis and nephrolithiasis were inconclusive. To the authors' best knowledge no studies were done to examine the associations between nephrolithiasis and dental calculus. Thus, the aim of this study is to compare the mineral composition of both dental calculus and nephrolithiasis and determine whether nephrolithiasis composition may be linked to the periodontal status.

Conditions

Periodontal Diseases; Nephrolithiasis

Outcome Measures

Primary Outcomes (1)

• the composition of both specimens

  The X-ray diffraction of both kidney stone and dental calculus will result in the composition of the two, and comparison will be done

  the analysis will take 9 months

Interventions

Scaling PROCEDURE

Scaling of dental calculus

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

patients diagnosed with kidney stone.

You may qualify if:

• Patients diagnosed with nephrolithiasis
• Over 18 years old

You may not qualify if:

• Pregnant woman, uncontrolled diabetes (HbA1c \> 7.5%), patients who received periodontal treatment in the past 6 months, smokers

Sponsors & Collaborators

• Rambam Health Care Campus: lead

Study Sites (1)

Rambam Health Care Campus, Dept. of Periodontology

Haifa, 31096, Israel

RECRUITING

Biospecimen

Retention: SAMPLES WITHOUT DNA

kidney stones and dental calculus

MeSH Terms

Conditions

Periodontal Diseases; Nephrolithiasis

Interventions

Tooth Exfoliation

Condition Hierarchy (Ancestors)

Mouth Diseases; Stomatognathic Diseases; Kidney Diseases; Urologic Diseases; Female Urogenital Diseases; Female Urogenital Diseases and Pregnancy Complications; Urogenital Diseases; Urolithiasis; Male Urogenital Diseases

Intervention Hierarchy (Ancestors)

Dental Physiological Phenomena; Digestive System and Oral Physiological Phenomena

Study Design

• Study Type: observational
• Observational Model: CASE ONLY
• Time Perspective: CROSS SECTIONAL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Prof

Study Record Dates

• First Submitted: March 30, 2017
• First Posted: April 5, 2017
• Study Start: May 11, 2017
• Primary Completion: December 1, 2018
• Study Completion: January 1, 2019
• Last Updated: May 16, 2018

Record last verified: 2018-03

Data Sharing

• IPD Sharing: Will not share

Locations

IL (1)