NCT03100201

Brief Summary

In this study, patients with upper arm fracture will receive an additive robotic-assisted training using the Armeo®Spring robot for three weeks on the injured arm in addition to conventional physio- and occupational therapy. The supportive treatment and execution of specific exercises on the Armeo®Spring should lead to improved recovery of function and mobility of the upper arm compared to conservatively treated patients.

Trial Health

87
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
48

participants targeted

Target at P25-P50 for not_applicable

Timeline
Completed

Started Feb 2016

Longer than P75 for not_applicable

Geographic Reach
1 country

3 active sites

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Start

First participant enrolled

February 15, 2016

Completed
1.1 years until next milestone

First Submitted

Initial submission to the registry

March 22, 2017

Completed
13 days until next milestone

First Posted

Study publicly available on registry

April 4, 2017

Completed
1.7 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

December 15, 2018

Completed
12 months until next milestone

Study Completion

Last participant's last visit for all outcomes

December 1, 2019

Completed
Last Updated

April 24, 2020

Status Verified

April 1, 2020

Enrollment Period

2.8 years

First QC Date

March 22, 2017

Last Update Submit

April 22, 2020

Conditions

Keywords

robotic-assisted rehabilitationhumeral fracturerandomised controlled study

Outcome Measures

Primary Outcomes (1)

  • Change in disability of the arm, shoulder and hand (DASH)

    subjective questionnaire for assessing the disability of the arm, shoulder and hand

    DASH will be assessed before randomisation and followed up after completing an intervention period of 3 weeks and additionally after 3, 6 and 12 months for assessing the change

Secondary Outcomes (3)

  • Change in the WMFT-O

    WMFT will be assessed before randomisation and followed up after completing an intervention period of 3 weeks for assessing the change

  • Change in ROM

    ROM will be assessed before randomisation and followed up after completing an intervention period of 3 weeks for assessing the change

  • Change in grip strength

    grip strength will be assessed before randomisation and followed up after completing an intervention period of 3 weeks for assessing the change

Study Arms (2)

Intervention Armeo®Spring

ACTIVE COMPARATOR

The intervention group will receive conventional occupational- and physiotherapy and an additive robotic-assisted training using the Armeo®Spring robot for three weeks.

Other: Intervention Armeo®Spring

Control group

ACTIVE COMPARATOR

The control group will receive conventional occupational- and physiotherapy.

Other: Control Group

Interventions

The robotic-assisted training will be performed using the clinically evaluated Armeo®Spring medical device (Hocoma AG, Zurich, Switzerland). By means of a sensory orthosis, arm movements will be supported and transmitted to a computer system and visually shown on a screen.

Intervention Armeo®Spring

The control group will receive conventional occupational- and physiotherapy over 3 weeks

Control group

Eligibility Criteria

Age35 Years - 70 Years
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64), Older Adult (65+)

You may qualify if:

  • surgical treatment of the shoulder joint after upper arm fracture classified as type AO 11
  • movement-stable fracture

You may not qualify if:

  • limited cognition as defined by a score in Short-Orientation-Memory-Concentration Test (SOMC) less than 10 points
  • inadequate level of pain during movement of the affected shoulder joint (pain score \>5 on a visual analogue pain scale)
  • strongly limited vision or hearing
  • heart failure (New York Heart Association stage III-IV) or COPD (Chronic Obstructive Pulmonary Disease) Gold stage III-IV
  • walking speed \<0.8m/sec
  • isolated tuberculum majus fracture of the humerus (AO 11, A1)
  • fractures with involvement of the glenoid cavity
  • double fractures
  • injury of the plexus or the axillaris nerve

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (3)

Berufsgenossenschaftliche Klinik Ludwigshafen

Ludwigshafen, 67071, Germany

Location

Berufsgenossenschaftliche Klinik Murnau

Murnau am Staffelsee, 82418, Germany

Location

Robert-Bosch-Hospital

Stuttgart, 70376, Germany

Location

Related Publications (3)

  • Handoll HH, Elliott J, Thillemann TM, Aluko P, Brorson S. Interventions for treating proximal humeral fractures in adults. Cochrane Database Syst Rev. 2022 Jun 21;6(6):CD000434. doi: 10.1002/14651858.CD000434.pub5.

  • Nerz C, Schwickert L, Scholch S, Gordt K, Nolte PC, Kroger I, Augat P, Becker C. Inter-rater reliability, sensitivity to change and responsiveness of the orthopaedic Wolf-Motor-Function-Test as functional capacity measure before and after rehabilitation in patients with proximal humeral fractures. BMC Musculoskelet Disord. 2019 Jul 6;20(1):315. doi: 10.1186/s12891-019-2691-0.

  • Nerz C, Schwickert L, Becker C, Studier-Fischer S, Mussig JA, Augat P. Effectiveness of robot-assisted training added to conventional rehabilitation in patients with humeral fracture early after surgical treatment: protocol of a randomised, controlled, multicentre trial. Trials. 2017 Dec 6;18(1):589. doi: 10.1186/s13063-017-2274-z.

MeSH Terms

Conditions

Shoulder InjuriesHumeral Fractures

Interventions

Control Groups

Condition Hierarchy (Ancestors)

Wounds and InjuriesArm InjuriesFractures, Bone

Intervention Hierarchy (Ancestors)

Epidemiologic Research DesignEpidemiologic MethodsInvestigative TechniquesResearch DesignMethods

Study Officials

  • Peter Augat, Prof.

    BG Unfallklinik Murnau

    STUDY CHAIR

Study Design

Study Type
interventional
Phase
not applicable
Allocation
RANDOMIZED
Masking
SINGLE
Who Masked
OUTCOMES ASSESSOR
Purpose
PREVENTION
Intervention Model
PARALLEL
Model Details: Patients will be recruited in three different clinics in Germany and randomised into an intervention and a control group. All patients will receive conventional occupational- and physiotherapy. The intervention group will receive an additive robotic-assisted training using the Armeo®Spring robot for three weeks.
Sponsor Type
OTHER
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
Research associate

Study Record Dates

First Submitted

March 22, 2017

First Posted

April 4, 2017

Study Start

February 15, 2016

Primary Completion

December 15, 2018

Study Completion

December 1, 2019

Last Updated

April 24, 2020

Record last verified: 2020-04

Data Sharing

IPD Sharing
Will not share

Locations