Development of a Musculoskeletal Model of the PIP Joint

NCT03094962 | Completed

• 1 other identifier: PUNI1713
• Study Type: interventional
• Target: 10
• Locations: 1 country
• Sites: 1

Brief Summary

The proximal interphalangeal (PIP) joint is the second joint in the finger from the finger tip. The outcome following replacement surgery of this joint is considered unsatisfactory. In order to improve these outcomes, it would be helpful to understand the geometry of the joint, how it moves and the forces that are involved. This can be achieved using computer models that model the bones and the soft tissues - musculoskeletal models. In order to make these models as representative as possible, they should be generated using anatomical data. Data will initially be extracted from patients' existing magnetic resonance imaging (MRI) and computed tomography (CT) scans. This will enable the computer model to begin being constructed. In parallel to the model initialisation, anatomical and motion data of the PIP joint of healthy volunteers will be collected. The necessary data will be collected using CT and MRI scans, as well as optical motion tracking methods. These data will then be used to populate the musculoskeletal model. Once the model is constructed, it will be used to simulate the motion of the joint and look at the effect of a simulated PIP joint replacement. This information should then provide insight as to how PIP joint replacements might be improved in future.

Conditions

Patient Specific Computational Modeling

Keywords

Kinematics; MRI Scans; CT Scan, Single-Photon Emission; finger interphalangeal joint

Outcome Measures

Primary Outcomes (3)

• Capturing hand kinematics using Vicon optical motion capture

  Capture hand kinematics of 10 healthy volunteers

  3 years

• Capturing images of the soft tissue in the hand using MR imaging

  Capture MR images of the hand for same 10 healthy volunteers as Outcome 1

  3 years

• Capturing images of the bony structures in the hand using CT scanning

  Capture CT images of the hand for same 10 healthy volunteers as Outcome 1

  3 years

Study Arms (1)

Motion capture, MR scan, CT scan

OTHER

All volunteers will go through the same data collection process

Other: Motion capture; Diagnostic Test: MR scan; Diagnostic Test: CT scan

Interventions

Motion capture OTHER

Capture kinematics of finger movements

Motion capture, MR scan, CT scan

MR scan DIAGNOSTIC_TEST

Capture MR images of hand and fingers in three postures

Motion capture, MR scan, CT scan

CT scan DIAGNOSTIC_TEST

Capture CT images of hand and fingers in three postures

Motion capture, MR scan, CT scan

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• In general good health
• University of Southampton members of staff
• Over 18 years old and able to provide informed consent
• No known problems relating to the PIP joint

You may not qualify if:

• Volunteers involved in other studies concerned with the function and anatomy of the PIP joint which would have adverse effects on this study and/or the study in which they are currently involved.
• Those undergoing treatment related to the PIP joint
• No metallic object should be present in the scanner and therefore those with any implanted metallic devices, or other devices which may cause or be caused adverse effects (e.g. metal plate, pacemaker)

Sponsors & Collaborators

• University of Southampton: lead

Study Sites (1)

University Hospital Southampton

Southampton, Hampshire, SO17 1BJ, United Kingdom

Location

Related Publications (1)

• Adams J, Ryall C, Pandyan A, Metcalf C, Stokes M, Bradley S, Warwick DJ. Proximal interphalangeal joint replacement in patients with arthritis of the hand: a meta-analysis. J Bone Joint Surg Br. 2012 Oct;94(10):1305-12. doi: 10.1302/0301-620X.94B10.29035.

  PMID: 23015553 BACKGROUND

MeSH Terms

Interventions

Motion Capture; Tomography, X-Ray Computed

Intervention Hierarchy (Ancestors)

Diagnostic Tests, Routine; Diagnostic Techniques and Procedures; Diagnosis; Investigative Techniques; Image Interpretation, Computer-Assisted; Diagnostic Imaging; Radiographic Image Enhancement; Image Enhancement; Photography; Radiography; Tomography, X-Ray; Tomography

Study Officials

• Christopher WG Phillips, PhD

  University of Southampton

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NA
• Masking: NONE
• Purpose: BASIC SCIENCE
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: March 9, 2017
• First Posted: March 29, 2017
• Study Start: January 21, 2015
• Primary Completion: September 5, 2017
• Study Completion: September 5, 2017
• Last Updated: November 15, 2018

Record last verified: 2018-11

Data Sharing

• IPD Sharing: Will not share

Locations

GB (1)