Diaphragm Ultrasound in Weaning From Mechanical Ventilation
The Efficacy of Ultrasound Assessment of Diaphragmatic Function in Guiding Weaning From Mechanical Ventilation in Critically Ill Patients With Abdominal Sepsis
1 other identifier
observational
30
1 country
1
Brief Summary
This study aims to evaluate the efficacy of ultrasound derived variables in prediction of success of weaning from mechanical ventilation in critically ill patients with abdominal sepsis
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at below P25 for all trials
Started Apr 2017
Shorter than P25 for all trials
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
Click on a node to explore related trials.
Study Timeline
Key milestones and dates
First Submitted
Initial submission to the registry
March 15, 2017
CompletedFirst Posted
Study publicly available on registry
March 29, 2017
CompletedStudy Start
First participant enrolled
April 1, 2017
CompletedPrimary Completion
Last participant's last visit for primary outcome
March 21, 2018
CompletedStudy Completion
Last participant's last visit for all outcomes
March 23, 2018
CompletedMarch 27, 2018
March 1, 2018
12 months
March 15, 2017
March 24, 2018
Conditions
Outcome Measures
Primary Outcomes (1)
Diaphragmatic thickening fraction
(calculated as maximum thickness - minimum thickness / maximum thickness)
five minutes before spontaneous breathing trial
Secondary Outcomes (6)
Diaphragmatic excursion
five minutes before spontaneous breathing trial and five minutes before patient extubation
Rapid shallow breathing index (RSBI)
five minutes before spontaneous breathing trial
Arterial blood gases
five minutes before spontaneous breathing trial and five minutes before patient extubation
Number of weaning trials
during the last 7 days
Heart rate
five minutes before spontaneous breathing trial and five minutes before patient extubation
- +1 more secondary outcomes
Eligibility Criteria
Critically ill patients with abdominal sepsis.
You may qualify if:
- Critically ill patients with abdominal sepsis with history of MV for more than 48 hours
You may not qualify if:
- Age \< 18 years and surgical dressings over the right lower rib cage which would preclude ultrasound examination will be excluded. Also, patients with chest trauma, thoracotomy, diaphragmatic paralysis, diaphragmatic dysfunction, diaphragmatic injury, diaphragmatic surgery and patients with neuromuscular diseases
Contact the study team to confirm eligibility.
Sponsors & Collaborators
- Cairo Universitylead
Study Sites (1)
Cairo University
Cairo, Egypt
Related Publications (1)
Eltrabili HH, Hasanin AM, Soliman MS, Lotfy AM, Hamimy WI, Mukhtar AM. Evaluation of Diaphragmatic Ultrasound Indices as Predictors of Successful Liberation From Mechanical Ventilation in Subjects With Abdominal Sepsis. Respir Care. 2019 May;64(5):564-569. doi: 10.4187/respcare.06391. Epub 2019 Jan 22.
PMID: 30670667DERIVED
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Study Officials
- STUDY DIRECTOR
Ahmed Mukhtar, Professor
Head of research committee section in anesthesia department
Study Design
- Study Type
- observational
- Observational Model
- COHORT
- Time Perspective
- PROSPECTIVE
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- Prinicpal investigator, Lecturer of anesthesia and critical care medicine
Study Record Dates
First Submitted
March 15, 2017
First Posted
March 29, 2017
Study Start
April 1, 2017
Primary Completion
March 21, 2018
Study Completion
March 23, 2018
Last Updated
March 27, 2018
Record last verified: 2018-03
Data Sharing
- IPD Sharing
- Will not share