Food Reward Processing in the Human Brain
Integration of Homeostatic Signaling and Food Reward Processing in the Human Brain
1 other identifier
observational
23
0 countries
N/A
Brief Summary
The aim of this study is to investigate the influence of different metabolic states and hormonal satiety signalling on responses in neural reward networks.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at below P25 for all trials
Started Jun 2015
Shorter than P25 for all trials
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
Study Start
First participant enrolled
June 9, 2015
CompletedPrimary Completion
Last participant's last visit for primary outcome
June 10, 2016
CompletedStudy Completion
Last participant's last visit for all outcomes
June 10, 2016
CompletedFirst Submitted
Initial submission to the registry
March 10, 2017
CompletedFirst Posted
Study publicly available on registry
March 16, 2017
CompletedMarch 29, 2022
March 1, 2022
1 year
March 10, 2017
March 28, 2022
Conditions
Keywords
Outcome Measures
Primary Outcomes (2)
Experimental fMRI task (incentive delay task)
Participants were expecting food and monetary related reward, after a correct response to a simple task they received either food or monetary related reward.
22 min.
Resting state brain activity using functional magnetic resonance imaging
Functional brain imaging will be employed to assess functional connectivity in reward related brain networks.
5 min.
Secondary Outcomes (2)
Analysis of hormonal satiety signaling
30 min. before scanning
Self-report questionnaire regarding eating behavior (Dutch Eating Behavior Questionnaire)
30 min.
Study Arms (1)
Healthy Controls
Normal weight, healthy female participants
Interventions
Participants were scanned twice: once after a meal and once after fasting for 24 hours
Eligibility Criteria
Healthy normal weight female participants
You may qualify if:
- BMI \<25 kg/m² and \>18.5 kg/m²
- no lifetime or current medical illness that could potentially affect appetite or body weight
- right-handedness
- normal or corrected-to-normal vision
You may not qualify if:
- history of head injury or surgery
- history of neurological disorder
- severe psychiatric disorder (psychosis, bipolar disorder, substance abuse)
- smoking
- borderline personality disorder
- current psychotropic medication
- inability to undergo fMRI scanning (e.g. metallic implants, claustrophobia, Pacemakers)
- pregnancy
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Related Publications (1)
Simon JJ, Wetzel A, Sinno MH, Skunde M, Bendszus M, Preissl H, Enck P, Herzog W, Friederich HC. Integration of homeostatic signaling and food reward processing in the human brain. JCI Insight. 2017 Aug 3;2(15):e92970. doi: 10.1172/jci.insight.92970. eCollection 2017 Aug 3.
PMID: 28768906DERIVED
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Study Officials
- PRINCIPAL INVESTIGATOR
Joe Simon, Dr. Dipl. Psych.
University Hospital Heidelberg
Study Design
- Study Type
- observational
- Observational Model
- COHORT
- Time Perspective
- CROSS SECTIONAL
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- Principal Investigator
Study Record Dates
First Submitted
March 10, 2017
First Posted
March 16, 2017
Study Start
June 9, 2015
Primary Completion
June 10, 2016
Study Completion
June 10, 2016
Last Updated
March 29, 2022
Record last verified: 2022-03
Data Sharing
- IPD Sharing
- Will not share