Detraining in People Living With HIV/AIDS

NCT03075332 | Completed

• 1 other identifier: VIVER MAIS
• Study Type: interventional
• Target: 2
• Locations: 1 country
• Sites: 2

Brief Summary

The goal of this study was to evaluate the effect of detraining in the components of physical aptitude of people living with HIV/Aids (PVHA).

Conditions

Lipodystrophy Syndrome, HIV; Sarcopenia

Keywords

Detraining; Physical aptitude; HIV

Outcome Measures

Primary Outcomes (1)

• Capacity cardiorespiratory

  ml (cardiorespiratory aptitude through the ergometer)

  21 weeks

Secondary Outcomes (1)

• test force

  21 weeks

Other Outcomes (1)

• body composition

  21 weeks

Study Arms (1)

protocol with physical exercise

EXPERIMENTAL

Both groups underwent a combined training intervention consisting of aerobic and resisted exercises in the same training session

Other: combined training

Interventions

combined training OTHER

Combined training consisting of aerobic and resisted training in the same training session for 15 weeks followed by 5 weeks of detraining

protocol with physical exercise

Eligibility Criteria

• Age: 18 Years - 70 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Group experience to have a diagnosis of at least 2 years living with HIV / AIDS being in clinical follow-up in the Specialized Attention Services in HIV / AIDS (SAE), using ART, TCD4 lymphocyte count equal to or greater than 500 copies / mm³, viral load Undetectable (≤ 50 copies / mm³)
• Group control without any diagnosis of HIV / AIDS or any other pathology. Both groups completed the exercise program with a minimum frequency of 75%.

You may not qualify if:

• Both groups taking part in any physical exercise in time of detraining

Sponsors & Collaborators

• Universidade Federal do Rio Grande do Norte: lead

Study Sites (2)

Juliany de Souza Araujo

Natal, Rio Grande do Norte, 59152600, Brazil

Location

Juliany de Souza Araujo

Parnamirim, Rio Grande do Norte, 59152600, Brazil

Location

Related Publications (6)

• Warshaw MG, Carey VJ, McFarland EJ, Dawson L, Abrams E, Melvin A, Fairlie L, Spiegel H, Jay J, Agwu AL; IMPAACT P1094 Team. The interaction between equipoise and logistics in clinical trials: A case study. Clin Trials. 2017 Jun;14(3):314-318. doi: 10.1177/1740774517690734. Epub 2017 Jan 31.

  PMID: 28135804 BACKGROUND

• Li A, McCabe T, Silverstein E, Dragan S, Salbach NM, Zobeiry M, Beldick S, Godi C, O'Brien KK. Community-Based Exercise in the Context of HIV: Factors to Consider when Developing and Implementing Community-Based Exercise Programs for People Living with HIV. J Int Assoc Provid AIDS Care. 2017 May/Jun;16(3):267-275. doi: 10.1177/2325957416686836. Epub 2017 Jan 11.

  PMID: 28074681 BACKGROUND

• Gomes Neto M, Conceicao CS, Oliveira Carvalho V, Brites C. Effects of Combined Aerobic and Resistance Exercise on Exercise Capacity, Muscle Strength and Quality of Life in HIV-Infected Patients: A Systematic Review and Meta-Analysis. PLoS One. 2015 Sep 17;10(9):e0138066. doi: 10.1371/journal.pone.0138066. eCollection 2015.

  PMID: 26378794 BACKGROUND

• Poton R, Polito M, Farinatti P. Effects of resistance training in HIV-infected patients: A meta-analysis of randomised controlled trials. J Sports Sci. 2017 Dec;35(24):2380-2389. doi: 10.1080/02640414.2016.1267389. Epub 2016 Dec 21.

  PMID: 28001474 BACKGROUND

• Chitu-Tisu CE, Barbu EC, Lazar M, Bojinca M, Tudor AM, Hristea A, Abagiu AO, Ion DA, Badarau AI. Body composition in HIV-infected patients receiving highly active antiretroviral therapy. Acta Clin Belg. 2017 Feb;72(1):55-62. doi: 10.1080/17843286.2016.1240426. Epub 2016 Oct 11.

  PMID: 27724840 BACKGROUND

• Araujo JS, de Medeiros RCDSC, da Silva TAL, de Medeiros DC, de Medeiros JA, Dos Santos IK, Wilde P, Cabral BGAT, Medeiros RMV, Dantas PMS. Effect of Training and Detraining in the Components of Physical Fitness in People Living With HIV/AIDS. Front Physiol. 2021 Sep 22;12:586753. doi: 10.3389/fphys.2021.586753. eCollection 2021.

  PMID: 34630129 DERIVED

MeSH Terms

Conditions

HIV-Associated Lipodystrophy Syndrome; Sarcopenia

Condition Hierarchy (Ancestors)

HIV Infections; Blood-Borne Infections; Communicable Diseases; Infections; Sexually Transmitted Diseases, Viral; Sexually Transmitted Diseases; Lentivirus Infections; Retroviridae Infections; RNA Virus Infections; Virus Diseases; Genital Diseases; Urogenital Diseases; Lipodystrophy; Skin Diseases, Metabolic; Skin Diseases; Skin and Connective Tissue Diseases; Lipid Metabolism Disorders; Metabolic Diseases; Nutritional and Metabolic Diseases; Immunologic Deficiency Syndromes; Immune System Diseases; Muscular Atrophy; Neuromuscular Manifestations; Neurologic Manifestations; Nervous System Diseases; Atrophy; Pathological Conditions, Anatomical; Pathological Conditions, Signs and Symptoms; Signs and Symptoms

Study Officials

• juliany araujo

  Universidade Federal do Rio Grande do Norte

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Masking: NONE
• Purpose: PREVENTION
• Intervention Model: SEQUENTIAL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: principal investigator

Model Details: This is a longitudinal study of the non-randomized experimental type, presenting a non-probabilistic sample for convenience and independent groups. The sample consisted of 21 individuals divided into 2 groups: Experimental Group (EG) and Control Group (CG). The EG was composed of 11 people living with HIV/AIDS and CG composed of 10 people with no infection

Study Record Dates

• First Submitted: February 9, 2017
• First Posted: March 9, 2017
• Study Start: February 19, 2016
• Primary Completion: June 21, 2016
• Study Completion: July 23, 2016
• Last Updated: March 9, 2017

Record last verified: 2017-02

Locations

BR (2)