Comparison of Different Ventilation Mode During One-lung Ventilation
Comparison of Pressure-controlled Ventilation With Volume-controlled Ventilation During One-lung Ventilation
1 other identifier
interventional
64
1 country
1
Brief Summary
It is controversial as to which ventilation mode is better in one-lung ventilation(OLV), volume controlled ventilation(VCV) or pressure controlled ventilation(PCV). This study was designed to figure out if there was any difference between these two modes on oxygenation and postoperative complications under the condition of protective ventilation(PV).
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P50-P75 for not_applicable
Started Jul 2016
Shorter than P25 for not_applicable
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
Click on a node to explore related trials.
Study Timeline
Key milestones and dates
Study Start
First participant enrolled
July 1, 2016
CompletedPrimary Completion
Last participant's last visit for primary outcome
September 1, 2016
CompletedStudy Completion
Last participant's last visit for all outcomes
December 1, 2016
CompletedFirst Submitted
Initial submission to the registry
February 6, 2017
CompletedFirst Posted
Study publicly available on registry
February 23, 2017
CompletedFebruary 23, 2017
February 1, 2017
2 months
February 6, 2017
February 21, 2017
Conditions
Outcome Measures
Primary Outcomes (4)
Airway pressure Ppeak
Airway pressure Ppeak in cmH2O.
during procedure
Airway pressure Pplat
Airway pressure Pplat in cmH2O.
during procedure
oxygenation index
Oxygenation index is calculated by PaO2/FiO2. PaO2 is measured by blood-gas analysis in mmHg. FiO2 is measured by gas monitor.
during procedure
oxygenation index
Oxygenation index is calculated by PaO2/FiO2. PaO2 is measured by blood-gas analysis in mmHg. FiO2 is calculated by \[21+4×oxygen flow(L/min)\]×100%.
surgery
Secondary Outcomes (1)
postoperative complications
within 30 days after surgery
Study Arms (2)
volume controlled ventilation (VCV)
OTHERVCV mode, tide volume 6ml/kg, f 12-14, set fixed tide volume for each breath
pressure controlled ventilation (PCV)
EXPERIMENTALPCV mode, pressure is adjusted to achieve tide volume 6ml/kg, f 12-14
Interventions
Eligibility Criteria
You may qualify if:
- ASA I-II, lateral decubitus position with at least 1h OLV and preoperative FEV1\>50% predicted
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
Zhongshan Hospital
Shanghai, Shanghai Municipality, 200032, China
Related Publications (2)
Song SY, Jung JY, Cho MS, Kim JH, Ryu TH, Kim BI. Volume-controlled versus pressure-controlled ventilation-volume guaranteed mode during one-lung ventilation. Korean J Anesthesiol. 2014 Oct;67(4):258-63. doi: 10.4097/kjae.2014.67.4.258. Epub 2014 Oct 27.
PMID: 25368784BACKGROUNDLin F, Pan L, Qian W, Ge W, Dai H, Liang Y. Comparison of three ventilatory modes during one-lung ventilation in elderly patients. Int J Clin Exp Med. 2015 Jun 15;8(6):9955-60. eCollection 2015.
PMID: 26309682BACKGROUND
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Study Design
- Study Type
- interventional
- Phase
- not applicable
- Allocation
- RANDOMIZED
- Masking
- DOUBLE
- Who Masked
- PARTICIPANT, OUTCOMES ASSESSOR
- Purpose
- SUPPORTIVE CARE
- Intervention Model
- PARALLEL
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- Professor
Study Record Dates
First Submitted
February 6, 2017
First Posted
February 23, 2017
Study Start
July 1, 2016
Primary Completion
September 1, 2016
Study Completion
December 1, 2016
Last Updated
February 23, 2017
Record last verified: 2017-02