Effectiveness of Lung Sono in One-lung Ventilation

NCT03770793 | Completed DMC

• 1 other identifier: JHSeo_LungSono
• Study Type: interventional
• Target: 166
• Locations: 1 country
• Sites: 1

Brief Summary

To observe the effectiveness of ultrasound-guided alveolar recruitment in thoracic surgery with one-lung ventilation(OLV).

Conditions

One Lung Ventilation

Keywords

One lung ventilation; Lung ultrasound; Alveolar recruitment

Outcome Measures

Primary Outcomes (2)

• Incidence of desaturation

  SpO2\<95%

  intraoperative

• P/F ratio

  PaO2/FiO2 ratio

  30 minutes after one-lung ventilation

Secondary Outcomes (3)

• Lung ultrasound score

  just after anesthesia induction, end of surgery

• Alveolar dead space

  30 minutes after one-lung ventilation

• Pulmonary complications

  intraoperative, during hospital stay(an average of 3 days)

Study Arms (2)

Lung-sono guided

EXPERIMENTAL

Before starting one-lung ventilation, alveolar recruitment is performed under the examination with ultrasound. Find the minimal airway pressure that actually starts to resolve the observed atelectasis. Repeat alveolar recruitment with the minimal pressure untill the atlelectasis is not visible.

Procedure: Lung-sono guided

Conventional

NO INTERVENTION

Before starting one-lung ventilation, alveolar recruitment is performed with the pressure of 30mmHg for 10 seconds which is a conventional method.

Interventions

Lung-sono guided PROCEDURE

The patient undergoing thoracic surgery is intubated with double lumen tube after induction of general anesthesia with propofol and remifentanil. In the intervention group, alveolar recruitment is performed to the non-surgical side of lung under examination with ultrasound just after anesthesia induction. During the gradual increment in the pressure of recruitment, the anesthesiologist can find the opening pressure that means the minimal pressure at which observed atelectasis starts to disappear. Then, alveolar recruitment is performed with the opening pressure until the atelectasis is not visible.

Lung-sono guided

Eligibility Criteria

• Age: 20 Years - 80 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Elective thoracic surgery which requires one-lung ventilation with lateral decubitus position

You may not qualify if:

• Patients who refuse to agree
• Previous lung surgical history
• History of pneumothorax or bullae
• Severe cardiopulmonary disease, COPD
• Operation time \< 1hr

Sponsors & Collaborators

• Seoul National University Hospital: lead

Study Sites (1)

Seoul National University Hospital

Seoul, South Korea

Location

Related Publications (2)

• Song IK, Kim EH, Lee JH, Kang P, Kim HS, Kim JT. Utility of Perioperative Lung Ultrasound in Pediatric Cardiac Surgery: A Randomized Controlled Trial. Anesthesiology. 2018 Apr;128(4):718-727. doi: 10.1097/ALN.0000000000002069.

  PMID: 29309282 BACKGROUND

• Kim BR, Lim L, You J, Yoon S, Park JB, Bahk JH, Seo JH. Effectiveness of ultrasound-guided alveolar recruitment in thoracic surgery with one-lung ventilation: a randomized-controlled trial. Eur J Cardiothorac Surg. 2025 Jul 1;67(7):ezaf204. doi: 10.1093/ejcts/ezaf204.

  PMID: 40581064 DERIVED

Study Officials

• Jeong-Hwa Seo, PhD

  Seoul National University Hospital

  STUDY CHAIR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: TRIPLE
• Who Masked: PARTICIPANT, CARE PROVIDER, OUTCOMES ASSESSOR
• Purpose: PREVENTION
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Professor

Study Record Dates

• First Submitted: December 6, 2018
• First Posted: December 10, 2018
• Study Start: December 7, 2018
• Primary Completion: May 7, 2019
• Study Completion: May 7, 2019
• Last Updated: November 12, 2020

Record last verified: 2020-11

Locations

KR (1)