NCT03059771

Brief Summary

Motivation deficits are a strong determinant of poor functional outcomes in people with schizophrenia. Mobile interventions are a promising approach to improving these deficits, as they can provide frequent cues and reinforcements that support goal-directed behavior. The primary aims of this study are to conduct a pilot study using a randomized design to 1) Test the feasibility and acceptability of a personalized mobile text message intervention, Mobile Enhancement of Motivation in Schizophrenia (MEMS) and to 2) Test the preliminary effectiveness of MEMS compared to a control condition.

Trial Health

87
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
59

participants targeted

Target at P25-P50 for not_applicable schizophrenia

Timeline
Completed

Started Feb 2017

Shorter than P25 for not_applicable schizophrenia

Geographic Reach
1 country

1 active site

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

First Submitted

Initial submission to the registry

February 16, 2017

Completed
7 days until next milestone

First Posted

Study publicly available on registry

February 23, 2017

Completed
5 days until next milestone

Study Start

First participant enrolled

February 28, 2017

Completed
11 months until next milestone

Primary Completion

Last participant's last visit for primary outcome

January 16, 2018

Completed
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

January 16, 2018

Completed
Last Updated

July 30, 2018

Status Verified

July 1, 2018

Enrollment Period

11 months

First QC Date

February 16, 2017

Last Update Submit

July 27, 2018

Conditions

SchizophreniaSchizo Affective DisorderPsychosis

Outcome Measures

Primary Outcomes (1)

  • Goal completion

    The percentage of baseline goals participants completed over the eight-week period will be assessed at the follow-up assessment.

    follow-up (8 weeks)

Secondary Outcomes (2)

  • Motivation and Pleasure Scale-Self-Report (MAP-SR)

    baseline and follow-up (8 weeks)

  • Intrinsic Motivation Index

    baseline and follow-up (8 weeks)

Study Arms (2)

Mobile Enhancement of Motivation (MEMS)

EXPERIMENTAL

Facilitators will first collaboratively help participants set personal recovery-goals using Collaborative Goal Technology (Clarke et al., 2006). Participants will then receive three sets of interactive text messages each weekday for eight weeks to reinforce and cue goal completion.

Behavioral: Mobile Enhancement of Motivation (MEMS)

Control

ACTIVE COMPARATOR

Participants will only engage in a goal-setting session where facilitators will collaboratively help participants set personal recovery-goals using Collaborative Goal Technology (Clarke et al., 2006).

Behavioral: Control

Interventions

Mobile Enhancement of Motivation (MEMS)BEHAVIORAL

The MEMS group will engage in a goal-setting session and then receive personalized text-messages to support goal attainment.

Mobile Enhancement of Motivation (MEMS)
ControlBEHAVIORAL

The control group will only engage in a goal-setting session.

Control

Eligibility Criteria

Age18 Years+
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64), Older Adult (65+)

You may qualify if:

  • Schizophrenia-spectrum diagnosis
  • Have a text-message enabled cell-phone
  • Are a current client at a participating community mental health center
  • Are in a non-acute phase of illness or have no medication changes or hospitalizations in the prior 30 days
  • Demonstrate a minimum of moderate motivation impairments according to the Clinical Assessment Interview for Negative Symptoms (CAINS; Kring et al., 2013)
  • Have an English reading level at or above the fourth grade according to the Graded Word List (Pray \& Ross, 1969)

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Midtown Community Mental Health Center

Indianapolis, Indiana, 46208, United States

Location

Related Publications (1)

  • Luther L, Fischer MW, Johnson-Kwochka AV, Minor KS, Holden R, Lapish CL, McCormick B, Salyers MP. Mobile enhancement of motivation in schizophrenia: A pilot randomized controlled trial of a personalized text message intervention for motivation deficits. J Consult Clin Psychol. 2020 Oct;88(10):923-936. doi: 10.1037/ccp0000599. Epub 2020 Aug 13.

    PMID: 32790451DERIVED

MeSH Terms

Conditions

SchizophreniaPsychotic Disorders

Interventions

Micro-Electrical-Mechanical Systems

Condition Hierarchy (Ancestors)

Schizophrenia Spectrum and Other Psychotic DisordersMental Disorders

Intervention Hierarchy (Ancestors)

Electrical Equipment and SuppliesEquipment and SuppliesManufactured MaterialsTechnology, Industry, and Agriculture

Study Design

Study Type
interventional
Phase
not applicable
Allocation
RANDOMIZED
Masking
SINGLE
Who Masked
OUTCOMES ASSESSOR
Purpose
TREATMENT
Intervention Model
PARALLEL
Sponsor Type
OTHER
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
Professor and Director of Clinical Psychology

Study Record Dates

First Submitted

February 16, 2017

First Posted

February 23, 2017

Study Start

February 28, 2017

Primary Completion

January 16, 2018

Study Completion

January 16, 2018

Last Updated

July 30, 2018

Record last verified: 2018-07

Locations

US(1)