NCT03049748

Brief Summary

The purpose of this study is to evaluate the use of VAD Care App in an out-patient mechanical circulatory support program. The specific aim for this pilot study is to obtain preliminary efficacy data of the VAD Care App as a self-management tool for patients with long-term LVADs. A randomized control trial will be employed to establish preliminary estimates of the effects of the App on the following outcomes: self-efficacy and adherence to the LVAD care regimen; LVAD-related complications and health care utilization \[e.g., hospital re-admission\]; overall health status and quality of life. The duration of the study is 6 months.

Trial Health

87
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
40

participants targeted

Target at P25-P50 for not_applicable heart-failure

Timeline
Completed

Started Jan 2017

Geographic Reach
1 country

3 active sites

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Start

First participant enrolled

January 30, 2017

Completed
5 days until next milestone

First Submitted

Initial submission to the registry

February 4, 2017

Completed
6 days until next milestone

First Posted

Study publicly available on registry

February 10, 2017

Completed
2.3 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

May 30, 2019

Completed
1 month until next milestone

Study Completion

Last participant's last visit for all outcomes

July 1, 2019

Completed
11 months until next milestone

Results Posted

Study results publicly available

May 27, 2020

Completed
Last Updated

June 16, 2020

Status Verified

May 1, 2020

Enrollment Period

2.3 years

First QC Date

February 4, 2017

Results QC Date

May 8, 2020

Last Update Submit

May 27, 2020

Conditions

Keywords

Heart-Assist Devices, Self-care, Quality of Life

Outcome Measures

Primary Outcomes (1)

  • Health-related Quality of Life

    Measured with the Kansas City Cardiomyopathy Questionnaire. A self-administered instrument consisting 23 items yielding a minimum and maximum values of 0 to 100 (overall summary score). Higher scores mean a better quality of life (i.e., a better outcome).

    Baseline (T0), 1 month (T1), 3 (T2) months, and 6 months post hospital discharge.

Secondary Outcomes (5)

  • Self-efficacy

    Baseline (T0), 1 month (T1), 3 (T2) months, and 6 months post hospital discharge.

  • Health Status

    Baseline (T0), 1 month (T1), 3 (T2) months, and 6 months post hospital discharge.

  • Adherence

    1 month (T1), 3 months (T2), and 6 months (T3) post hosp discharge.

  • Complications

    1 month (T1), 3 months (T2), and 6 months (T3) post hosp discharge.

  • Hospital Readmission

    1 month (T1), 3 months (T2), and 6 months (T3) post hosp discharge.

Study Arms (2)

Control Group

ACTIVE COMPARATOR

Participants in the control group (20 LVAD patients) will receive usual care over 6 months. Usual care consists of routine clinic visits/follow-up at 1, 3, and 6 months post hospital discharge. A customary LVAD self-management/discharge education and training will be provided to patients and caregiver before hospital discharge and as need throughout the duration of the study. The control group will NOT receive the VAD Care App.

Other: Usual LVAD Care

Intervention Group

EXPERIMENTAL

Participants in the experimental group (20 LVAD patients) will receive usual care plus VAD Care App. They will implement LVAD self-management as directed by VAD Care App. The app will be used daily by patients and/or caregivers for over 6 months. Their LVAD self-management competencies will be assessed at months 1 and 5 post hospital discharge with a review of LVAD self-management skills provided by the LVAD RN Coordinator.

Device: Mobile phone app (VAD Care App)Other: Usual LVAD Care

Interventions

VAD Care App is a novel self-management tool being tested for patients with implantable LVADs. The app has daily "push notifications (alerts)," cues for daily self-management tasks, two-way communication using text messages and videoconferencing (virtual clinic), and links to LVAD self-management skills and videos easily accessible for self-management skill review.

Intervention Group

Routine clinic follow-up visits over 6 months. Patients and caregivers will both receive self-management education post discharge and as needed throughout the duration of the study.

Control GroupIntervention Group

Eligibility Criteria

Age21 Years - 80 Years
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64), Older Adult (65+)

You may qualify if:

  • Patients: Recipient of second or third generation LVAD; minimum of 6th grade education; can read and understand the English Language; and to be discharged from the hospital within a week of enrollment
  • Caregivers: Designated as primary caregiver at home and a minimum of 6th grade education

You may not qualify if:

  • Patients and caregivers: Illiterate, blind, inability to use a mobile phone, cannot hear alarms, and/or evidence of cognitive impairment documented in the medical record or an abnormal results of a Mini Mental State Exam

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (3)

Barnes-Jewish Hospital/Washington University

St Louis, Missouri, 63108, United States

Location

Bryan Heart

Lincoln, Nebraska, 68506, United States

Location

New York Presbyterian Columbia University Medical Center

New York, New York, 10032, United States

Location

Related Links

MeSH Terms

Conditions

Heart Failure

Condition Hierarchy (Ancestors)

Heart DiseasesCardiovascular Diseases

Results Point of Contact

Title
Dr. Jesus Casida
Organization
Johns Hopkins University (Former Faculty at University of Michigan)

Study Officials

  • Jesus Casida, PhD

    University of Michigan

    PRINCIPAL INVESTIGATOR

Publication Agreements

PI is Sponsor Employee
No
Restrictive Agreement
No

Study Design

Study Type
interventional
Phase
not applicable
Allocation
RANDOMIZED
Masking
NONE
Purpose
SUPPORTIVE CARE
Intervention Model
PARALLEL
Sponsor Type
OTHER
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
Assistant Professor

Study Record Dates

First Submitted

February 4, 2017

First Posted

February 10, 2017

Study Start

January 30, 2017

Primary Completion

May 30, 2019

Study Completion

July 1, 2019

Last Updated

June 16, 2020

Results First Posted

May 27, 2020

Record last verified: 2020-05

Data Sharing

IPD Sharing
Will share

Data sharing will be made available for research to those who request it once analyses of specific aims have been conducted and findings have been published. All data will be de-identified. Persons interested in using the data will need to submit a request in writing, stating their intended use. Data will be made available at cost. Requirements for sharing will include acknowledgement in all publications of the funding source and of the study authors. Data sets will be accompanied by a data dictionary for all study variables, both derived and raw data. We will consider the most cost-effective means for sharing data after a data-sharing agreement has been reached. For example, data may be copied to a CD or DVD, be posted on a password protected and secure web site, or made available through a third party data archive service. We will also share research findings through publications and presentations at scholarly research meetings.

Shared Documents
STUDY PROTOCOL, SAP
Time Frame
September 2019 to 2021
Access Criteria
As described in the data sharing plan above

Locations