Deployment-Related Lung Disease Research Database and Biorepository

NCT03035097 | Recruiting

• 1 other identifier: HS-2689
• Study Type: observational
• Target: 500
• Locations: 1 country
• Sites: 1

Brief Summary

The purpose of this research study is to establish a research database and biorepository for patients at National Jewish Health (NJH) who served in Operation Iraqi Freedom (OIF) or Operation Enduring Freedom (OEF). This study will also include civilian contractors who worked as part of these military operations in Iraq or Afghanistan. The biorepository would store blood samples obtained from these patients during a clinic visit. The research database would store prospectively and retrospectively collected clinical and exposure data that would enable us to comprehensively characterize each case.

Conditions

Bronchiolitis

Outcome Measures

Primary Outcomes (1)

• collect symptom and exposure data

  each subject will complete a questionnaire

  Up to 24 months

Interventions

Biorepository OTHER

One-time blood draw for blood to be stored in a biorepositoy

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Patients who served in the southwest Asia will be approached for inclusion in the study. If patients agree to participate in the biorepository, a one-time blood draw will occur. If the subject has had a previous bronchoscopy or a surgical lung biopsy and has excess samples the study would collect those to add to the biorepository.

You may qualify if:

• Served in the southwest Asia wars

You may not qualify if:

• Did not served in the southwest Asia wars

Sponsors & Collaborators

• National Jewish Health: lead

Study Sites (1)

National Jewish Health

Denver, Colorado, 80206, United States

RECRUITING

Related Publications (2)

• Zell-Baran LM, Meehan R, Wolff J, Strand M, Krefft SD, Gottschall EB, Macedonia TV, Gross JE, Sanders OL, Pepper GC, Rose CS. Military Occupational Specialty Codes: Utility in Predicting Inhalation Exposures in Post-9/11 Deployers. J Occup Environ Med. 2019 Dec;61(12):1036-1040. doi: 10.1097/JOM.0000000000001731.

  PMID: 31592941 BACKGROUND

• Krefft SD, Wolff J, Zell-Baran L, Strand M, Gottschall EB, Meehan R, Rose CS. Respiratory Diseases in Post-9/11 Military Personnel Following Southwest Asia Deployment. J Occup Environ Med. 2020 May;62(5):337-343. doi: 10.1097/JOM.0000000000001817.

  PMID: 31977922 BACKGROUND

Biospecimen

Retention: SAMPLES WITH DNA

If patients consent to having blood and tissue collected for the biorepository, the samples will be collected during a clinic visit. Two DNA PAXgene tubes will be used to collect 17ml of blood and two RNA PAXgene tubes would be used to collect 5 ml of blood. In addition, excess bronchoalveolar lavage (BAL) fluid from a clinically-indicated bronchoscopy would also be collected. Blood and BAL fluid will be frozen and stored in -80 degree C freezers in the Occupational Medicine Laboratory until processed. If a patient will have a surgical or transbronchial biopsy as part of his or her clinical evaluation, any excess lung tissue that has been formalin-fixed and paraffin-embedded will also be collected and stored in the Occupational Medicine facilities.

MeSH Terms

Conditions

Bronchiolitis

Interventions

Biological Specimen Banks

Condition Hierarchy (Ancestors)

Bronchitis; Respiratory Tract Infections; Infections; Bronchial Diseases; Respiratory Tract Diseases; Lung Diseases, Obstructive; Lung Diseases

Intervention Hierarchy (Ancestors)

Health Facilities; Health Care Facilities Workforce and Services

Central Study Contacts

Lauren Zell-Baran, PhD, MPH

CONTACT

303-398-1187; zell-baranl@njhealth.org

Study Design

• Study Type: observational
• Observational Model: OTHER
• Time Perspective: OTHER
• Target Duration: 1 Day
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Principal Investigator

Study Record Dates

• First Submitted: January 4, 2017
• First Posted: January 27, 2017
• Study Start: February 1, 2013
• Primary Completion (Estimated): December 1, 2030
• Study Completion (Estimated): December 1, 2030
• Last Updated: April 15, 2026

Record last verified: 2026-04

Locations

US (1)