Immature Myeloid Cells in Respiratory Syncytial Virus Bronchioliltis

NCT01684527 | Unknown DMC

• 1 other identifier: 0039-12-HYMC
• Study Type: observational
• Target: 55
• Locations: 1 country
• Sites: 1

Brief Summary

The investigators hypothesize that Respiratory Syncytial Virus (RSV) infection may influence the population of lung immature myeloid cells and dendritic cells in a way that will impair their ability to invoke an effective immune response and lead to prolonged inflammation, angiogenesis and scarring. This may lead in turn to disturbed lung function. Our aim is to determine the presence and phenotype of immature myeloid cells present in respiratory secretions of children with RSV bronchiolitis as compared to non-RSV bronchiolitis and healthy controls.

Conditions

Bronchiolitis

Outcome Measures

Primary Outcomes (1)

• Number of Immature Myeloid Cells in Respiratory Secretions

  Respiratory secretions obtained from child presenting with bronchiolitis will be examined for the presence of immature myeloid cells

  Participants will be followed for the duration of hospital stay, an expected average of one week

Study Arms (2)

Children Suffering From Bronchiolitis

Respiratory secretions obtained from children suffering from Bronchiolitis

Other: Respiratory secretions obtained

Healthy Children

Respiratory secretions obtained from children with no respiratory infection

Other: Respiratory secretions obtained

Interventions

Respiratory secretions obtained OTHER

Children Suffering From Bronchiolitis; Healthy Children

Eligibility Criteria

• Age: Up to 2 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Child (0-17)
• Sampling Method: Probability Sample

Study Population

Children presenting in our pediatric department suffering from bronchiolitis

You may qualify if:

• Bronchiolitis

You may not qualify if:

• Chronic disease

Sponsors & Collaborators

• Hillel Yaffe Medical Center: lead

Study Sites (1)

Hillel Yaffe Medical Center

Hadera, 38100, Israel

Location

MeSH Terms

Conditions

Bronchiolitis

Condition Hierarchy (Ancestors)

Bronchitis; Respiratory Tract Infections; Infections; Bronchial Diseases; Respiratory Tract Diseases; Lung Diseases, Obstructive; Lung Diseases

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER GOV
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: September 5, 2012
• First Posted: September 13, 2012
• Study Start: October 1, 2012
• Primary Completion: January 1, 2014
• Study Completion: January 1, 2014
• Last Updated: September 13, 2012

Record last verified: 2012-09

Locations

IL (1)