A Comparison of Cognitive Training Approaches in Psychotic Disorders
1 other identifier
interventional
70
1 country
1
Brief Summary
Cognitive remediation (CR) is the best treatment to improve neurocognitive abilities for individuals with psychosis, however, there is no gold standard method of cognitive remediation available. Cognitive training refers to the training component of CR in which people practice computerized exercises that train specific cognitive abilities. There is no agreed upon approach within the field as to the type of training that is most effective with some studies, training higher level cognitive abilities, some training perceptual abilities, and others training general cognitive skills. This study will directly compare two competing methods of cognitive training on measures of neurophysiology, neurocognition, functional competence, and real-world functional performance.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P50-P75 for not_applicable
Started Aug 2016
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
Click on a node to explore related trials.
Study Timeline
Key milestones and dates
Study Start
First participant enrolled
August 1, 2016
CompletedFirst Submitted
Initial submission to the registry
October 27, 2016
CompletedFirst Posted
Study publicly available on registry
January 18, 2017
CompletedPrimary Completion
Last participant's last visit for primary outcome
March 1, 2018
CompletedStudy Completion
Last participant's last visit for all outcomes
March 1, 2018
CompletedNovember 14, 2018
November 1, 2018
1.6 years
October 27, 2016
November 12, 2018
Conditions
Outcome Measures
Primary Outcomes (1)
Change in Functional Performance - Specific Levels of Functioning (SLOF) from Baseline
Rating scale completed by participants' case managers that rates their ability to perform different everyday tasks
Post-treatment (within 2 weeks following the end of treatment)
Secondary Outcomes (7)
Change in Neurocognition - MATRICS Cognitive Consensus Battery (MCCB) from Baseline
Post-treatment (within 2 weeks following the end of treatment)
Change in Neurophysiology - EEG from Baseline
Post-treatment (within 2 weeks following the end of treatment)
Functional Competence - Canadian Objective Assessment of Life Skills Brief (COALS-B) from Baseline
Post-treatment (within 2 weeks following the end of treatment)
Change in Functional Performance - Specific Levels of Functioning (SLOF) from Baseline
Follow-Up (3 months after the end of treatment)
Change in Neurocognition - MATRICS Cognitive Consensus Battery (MCCB) from Baseline
Follow-Up (3 months after the end of treatment)
- +2 more secondary outcomes
Study Arms (2)
Executive Training
EXPERIMENTALExecutive Training (ET) involves training on computerized cognitive exercises that have graded increases in difficulty so that the participant is always challenged. A therapist will be in the room with participants to address any difficulties with the program and facilitate generation of strategies. ET will be delivered in both individual and group settings.
Perceptual Training
EXPERIMENTALPerceptual Training (PT) involves training on computerized cognitive exercises that have graded increases in difficulty so that the participant is always challenged. A therapist will be in the room with participants to address any difficulties with the program and facilitate generation of strategies. PT will be delivered in both individual and group settings.
Interventions
Cognitive remediation is a cognitive and behavioural therapy designed to improve cognitive skills such as memory, and problem solving ability.
Cognitive remediation is a cognitive and behavioural therapy designed to improve cognitive skills such as attention, and processing speed.
Eligibility Criteria
You may qualify if:
- psychotic disorder
- No previous cognitive remediation in past 6 months
You may not qualify if:
- Brain injury
- Substance abuse
- Neurocognitive disorder
- Developmental Disability
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
Queen's University
Kingston, Ontario, K7L 5P6, Canada
Related Publications (1)
Best MW, Milanovic M, Iftene F, Bowie CR. A Randomized Controlled Trial of Executive Functioning Training Compared With Perceptual Training for Schizophrenia Spectrum Disorders: Effects on Neurophysiology, Neurocognition, and Functioning. Am J Psychiatry. 2019 Apr 1;176(4):297-306. doi: 10.1176/appi.ajp.2018.18070849. Epub 2019 Mar 8.
PMID: 30845819DERIVED
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Study Design
- Study Type
- interventional
- Phase
- not applicable
- Allocation
- RANDOMIZED
- Masking
- DOUBLE
- Who Masked
- PARTICIPANT, OUTCOMES ASSESSOR
- Purpose
- TREATMENT
- Intervention Model
- PARALLEL
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- Principal Investigator
Study Record Dates
First Submitted
October 27, 2016
First Posted
January 18, 2017
Study Start
August 1, 2016
Primary Completion
March 1, 2018
Study Completion
March 1, 2018
Last Updated
November 14, 2018
Record last verified: 2018-11
Data Sharing
- IPD Sharing
- Will not share