Short-term Working Memory and Executive Training

NCT02168166 | Completed

• 1 other identifier: GPSYC-651-14
• Study Type: interventional
• Target: 40
• Locations: 1 country
• Sites: 1

Brief Summary

Cognitive remediation (CR) therapies refer to a number of recent developments to use behavioural strategies to improve neurocognitive abilities and improve everyday functioning in mental disorders such as schizophrenia, bipolar disorder, and depression. In this study, we aim to examine whether we can observe CR effects on measures of neuroplasticity, cognition, and functioning when using a rigorous control comparison group. We hypothesize that the active group will exhibit improvements in executive functioning composite scores, improved EEG theta-gamma frequency modulation, and increased EEG alpha power compared to the placebo group.

Conditions

Psychotic Disorders

Keywords

Neurological Disorders; Neuroscience; Neuropsychology; EEG; Cognitive remediation; Cognitive Response

Outcome Measures

Primary Outcomes (1)

• Change from baseline executive functioning composite score at post-treatment assessment

  Composite score based on four tests of cognition

  Pre-training assessment (Week 1) and post-training assessment (Week 4)

Secondary Outcomes (2)

• Change from baseline EEG theta-gamma frequency modulation at post-treatment assessment

  Pre-training assessment (Week 1) and post-training assessment (Week 4)

• Change from baseline EEG alpha power at post-treatment assessment

  Pre-training assessment (Week 1) and post-training assessment (Week 4)

Study Arms (2)

Executive Function Training

ACTIVE COMPARATOR

Two weeks of training of cognitive domain of executive functioning Using online program (Scientific Brain Training Pro) Four exercises

Behavioral: Executive Function Training

Placebo Training

PLACEBO COMPARATOR

Two weeks of training with exercises not affecting working memory, information processing speed, or cognitive load Exercises maintain other traditional progressive aspects to preserve appearance of dynamic titration of difficulty levels Using online program (Scientific Brain Training Pro) Four exercises

Behavioral: Placebo

Interventions

Executive Function Training BEHAVIORAL

Executive Function Training

Placebo BEHAVIORAL

Placebo version of executive function training

Placebo Training

Eligibility Criteria

• Age: 18 Years - 65 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• diagnosis of a chronic mental disorder (defined herein as bipolar disorder, major depressive disorder, or a schizophrenia-spectrum disorder)
• between the ages of 18 and 65
• speak and read fluent English
• able to use a computer

You may not qualify if:

• active substance abuse or dependence diagnosis
• sensory or motor issues that would preclude completion of study procedures
• enrollment in a cognitive remediation program or use of cognitive training programs (e.g. lumosity.com) within the past 6 months

Sponsors & Collaborators

• Queen's University: lead

Study Sites (1)

Queen's University

Kingston, Ontario, K7L3N6, Canada

Location

MeSH Terms

Conditions

Psychotic Disorders; Nervous System Diseases

Condition Hierarchy (Ancestors)

Schizophrenia Spectrum and Other Psychotic Disorders; Mental Disorders

Study Officials

• Christopher Bowie, PhD, CPsych

  Queen's University

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: SINGLE
• Who Masked: PARTICIPANT
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Dr.

Study Record Dates

• First Submitted: June 16, 2014
• First Posted: June 20, 2014
• Study Start: May 1, 2014
• Primary Completion: June 1, 2017
• Study Completion: June 1, 2017
• Last Updated: April 4, 2018

Record last verified: 2018-04

Locations

CA (1)