the New Biomarker of the Knee Osteoarthritis Knee Osteoarthritis Occurrence and Progression

NCT03015688 | Completed

• 1 other identifier: 2012-06-01
• Study Type: observational
• Target: 460
• Locations: 0 countries
• Sites: N/A

Brief Summary

It was previously proved an association of TGF-β1 and PDGF-BB with the pathogenesis of osteoarthritis (OA) by experiments of OA animal models. In this study, we aimed to determine whether serum concentrations of TGF-β1, PDGF-BB and CTX-1 were related to the knee OA. knee OA cases were collected from the first affiliated hospital of Shihezi university and healthy controls were recruited from the community. The severity of knee OA was defined as kellgren-lawrence (K-L) classification criteria.Serum levels of chemical biomarkers were compared between knee OA cases and controls or among K-L grade 2 to grade 4 groups. The serum concentrations of the TGF-β1, PDGF-BB and CTX-1 were determined by ELISA .

Conditions

Knee Osteoarthritis

Keywords

Biomarkers

Outcome Measures

Primary Outcomes (1)

• Serum levels of Transforming Growth Factor Beta1 (TGF-β1) and Platelet Derived Growth Factor BB (PDGF-BB) may be novel biomarkers in knee osteoarthritis

  3 years

Study Arms (2)

knee OA

OA diagnosis was on the basis of the diagnosis and treatment guideline of the American Academy of Orthopedic Surgeons Participants who met the following criteria were excluded：the knee OA concomitant with hip OA, suppurative and rheumatoid arthritis, gout patients, patients who underwent knee arthroscopy surgery within 6 months, bilateral or unilateral knee replacements, the knee joint trauma patients, histories of glucocorticoid and/or sterol hormones.

Radiation: x-ray images

Control

"no often have pain, aching or stiffness in your Left/right knee during last month","no Left/right knee trauma history","no histories of glucocorticoid and/or sterol hormones" normal knee X-ray images,

Radiation: x-ray images

Interventions

x-ray images RADIATION

Control; knee OA

Eligibility Criteria

• Age: 38 Years - 78 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

210 patients diagnosed with knee OA in clinics were found in hospital patients . Healthy controls were recruited from community questionnaires in Shihezi city, Xinjiang province, China.

You may qualify if:

• OA diagnosis was on the basis of the diagnosis and treatment guideline of the American Academy of Orthopedic Surgeons

You may not qualify if:

• Participants who met the following criteria were excluded：
• the knee OA concomitant with hip OA,
• suppurative and rheumatoid arthritis,
• gout patients,
• patients who underwent knee arthroscopy surgery within 6 months,
• bilateral or unilateral knee replacements,
• the knee joint trauma patients,
• histories of glucocorticoid and/or sterol hormones.

Sponsors & Collaborators

• Shihezi University: lead

MeSH Terms

Conditions

Osteoarthritis, Knee

Condition Hierarchy (Ancestors)

Osteoarthritis; Arthritis; Joint Diseases; Musculoskeletal Diseases; Rheumatic Diseases

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: CROSS SECTIONAL
• Target Duration: 1 Year
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Principal investigator

Study Record Dates

• First Submitted: January 6, 2017
• First Posted: January 10, 2017
• Study Start: June 1, 2012
• Primary Completion: January 1, 2015
• Study Completion: June 1, 2015
• Last Updated: January 10, 2017

Record last verified: 2017-01