Non-surgical Treatment of Knee Osteoarthritis - a Comparison of Effects in 2200 Patients

NCT02091830 | Completed

• 1 other identifier: The 07 - 11 cohort
• Study Type: observational
• Target: 2,262
• Locations: 1 country
• Sites: 1

Brief Summary

The purpose of this study is to assess whether radiographic osteoarthritis severity (OA; Kellgren-Lawrence scale) is associated with self-reported improvement in pain after non-surgical treatments (physiotherapy, pain killers, injection, other treatments). The hypothesis is that radiographic OA severity is inversely associated with self-reported improvement.

Conditions

Knee Osteoarthritis

Outcome Measures

Primary Outcomes (1)

• Self-reported improvement

  Assessed using the question: Has your pain improved? Response categories: pain free; better; unchanged; worse

  2-5 years after consulting orthopedic surgeon

Study Arms (1)

Non-surgical treatment

Drug: Paracetamol and nonsteroidal antiinflammatory drug (NSAID); Other: Physiotherapy; Drug: Cortisone Injection; Other: Others

Interventions

Paracetamol and nonsteroidal antiinflammatory drug (NSAID) DRUG

Non-surgical treatment

Physiotherapy OTHER

Non-surgical treatment

Cortisone Injection DRUG

Non-surgical treatment

Others OTHER

Non-surgical treatment

Eligibility Criteria

• Sex: all
• Healthy Volunteers: No
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

2200 patients with knee osteoarthritis not eligible for at total knee arthroplasty

You may qualify if:

• Not eligible for at total knee arthroplasty

You may not qualify if:

• Ipsilateral knee arthroplasty

Sponsors & Collaborators

• Northern Orthopaedic Division, Denmark: lead

Study Sites (1)

Department of Orthopedic Surgery

Aalborg, 9000, Denmark

Location

MeSH Terms

Conditions

Osteoarthritis, Knee

Interventions

Acetaminophen; Anti-Inflammatory Agents, Non-Steroidal; Physical Therapy Modalities; Cortisone; Bro protein, Drosophila

Condition Hierarchy (Ancestors)

Osteoarthritis; Arthritis; Joint Diseases; Musculoskeletal Diseases; Rheumatic Diseases

Intervention Hierarchy (Ancestors)

Acetanilides; Anilides; Amides; Organic Chemicals; Aniline Compounds; Amines; Analgesics, Non-Narcotic; Analgesics; Sensory System Agents; Peripheral Nervous System Agents; Physiological Effects of Drugs; Pharmacologic Actions; Chemical Actions and Uses; Anti-Inflammatory Agents; Therapeutic Uses; Antirheumatic Agents; Therapeutics; Rehabilitation; Pregnenes; Pregnanes; Steroids; Fused-Ring Compounds; Polycyclic Compounds; 17-Hydroxycorticosteroids; Hydroxycorticosteroids; Adrenal Cortex Hormones; Hormones; Hormones, Hormone Substitutes, and Hormone Antagonists

Study Officials

• Michael Rathleff, MSc

  Department of Occupational Therapy and Physiotherapy, Aalborg University Hospital, Denmark.

  STUDY CHAIR

• Mikkel M Andersen, MSc

  Department of Mathematical Sciences, Aalborg University

  STUDY CHAIR

• Ole Simonsen, MD, DMSc

  Department of Orthopedic Surgery

  PRINCIPAL INVESTIGATOR

• Christina A Derosche, BSc

  Department of Orthopedic Surgery

  STUDY CHAIR

• Signe B Pedersen

  Department of Orthopedic Surgery

  STUDY CHAIR

• Søren T Skou, MSc

  Orthopedic Surgery Research Unit + Department of Health Science and Technology, Aalborg University

  STUDY CHAIR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: MD, DMSc

Study Record Dates

• First Submitted: March 18, 2014
• First Posted: March 19, 2014
• Study Start: January 1, 2013
• Primary Completion: July 1, 2014
• Study Completion: July 1, 2014
• Last Updated: October 20, 2015

Record last verified: 2015-10

Locations

DK (1)