The Neural Substrates for Working Memory Training
WMT
The Study on the Brain Mechanisms for the Rehabilitation of Working Memory Deficits in Patients With Acquired Brain Injury Using Multimodal Magnetic Resonance Imaging
1 other identifier
interventional
40
1 country
1
Brief Summary
This study aims to conduct a contrast study on the characteristics of functional and structural connectivity of neural networks of working memory in patients with acquired brain injury versus normal controls, using resting-state functional connectivity magnetic resonance imaging, task-specific functional magnetic resonance imaging and diffusion tensor imaging, combined with cognitive behavioral examinations. Another purpose is to reveal the characteristics of dynamic change of neural networks of working memory pre- and post-intervention in patients with working memory dysfunction.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P25-P50 for phase_2
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
Study Start
First participant enrolled
October 1, 2012
CompletedFirst Submitted
Initial submission to the registry
December 31, 2016
CompletedFirst Posted
Study publicly available on registry
January 6, 2017
CompletedPrimary Completion
Last participant's last visit for primary outcome
October 1, 2018
CompletedJanuary 6, 2017
January 1, 2017
6 years
December 31, 2016
January 4, 2017
Conditions
Outcome Measures
Primary Outcomes (1)
Training-induced brain activations during working memory tasks in fMRI
Training-induced increased and decreased brain activations (Number of voxels) during n-back verbal WM task compared to the pre-training baseline
six weeks
Secondary Outcomes (2)
The fluid intelligence measured by Raven's Standard Progressive Matrices (RSPM) test
six weeks
Attention ability assessed by Stroop color-word test
six weeks
Study Arms (2)
Working Memory Training
EXPERIMENTALThe subjects of experimental group received a series of working memory training, 30 min for 5 days per week during 6 weeks.
Non-Working Memory Training
NO INTERVENTIONThe subjects of control group performed traditional cognitive rehabilitation without working memory training, 30 min for 5 days per week during 6 weeks.
Interventions
Eligibility Criteria
You may qualify if:
- Right handedness
- Diagnosis of traumatic brain injury or stroke
- Course of disease within one year
- The score of MoCA test \> 24
- Able to understand instructions
You may not qualify if:
- Aphasia, unilateral spatial neglect, agnosia, apraxia
- Hearing impairment or visual impairment
- History of taking psychiatric drugs
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
Department of Rehabilitation Evaluation, China Rehabilitation Research Center
Beijing, Beijing Municipality, 100068, China
Study Officials
- PRINCIPAL INVESTIGATOR
Xiaoping Yun, MD
Department of Rehabilitation Evaluation, China Rehabilitation Research Center
Central Study Contacts
Study Design
- Study Type
- interventional
- Phase
- phase 2
- Allocation
- RANDOMIZED
- Masking
- TRIPLE
- Who Masked
- PARTICIPANT, INVESTIGATOR, OUTCOMES ASSESSOR
- Purpose
- TREATMENT
- Intervention Model
- PARALLEL
- Sponsor Type
- OTHER GOV
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- Director of Department of Rehabilitation Evaluation
Study Record Dates
First Submitted
December 31, 2016
First Posted
January 6, 2017
Study Start
October 1, 2012
Primary Completion
October 1, 2018
Last Updated
January 6, 2017
Record last verified: 2017-01