Neural Bases of Multiple Forms of Self-regulatory Control in Bulimia Nervosa

NCT02997475 | Completed

• 2 other identifiers: 151514F32MH108311
• Study Type: observational
• Target: 89
• Locations: 1 country
• Sites: 1

Brief Summary

The purpose of this study is to investigate areas of the brain responsible for self-regulation in adult women who have never had an eating disorder with women who have bulimia nervosa. More specifically, investigators are interested in changes in brain activation (e.g., changes in blood flow and oxygen use) when inhibiting responses and regulating emotions. Data collection will rely on a technology called functional magnetic resonance imaging (fMRI).

Conditions

Bulimia Nervosa

Keywords

Bulimia Nervosa; Bulimia; fMRI; Emotion Regulation; Response Inhibition

Outcome Measures

Primary Outcomes (1)

• Self-Regulatory Control

  Functional Magnetic Resonance Imaging will be used to assess brain activation associated with motor inhibitory control and affect regulation in women with bulimia nervosa (BN)

  Day 2 (fMRI Scan)

Secondary Outcomes (2)

• Goal-Directed Action Control

  Day 1

• Eating Disorder Relevance

  Day 0

Study Arms (2)

Women with Bulimia Nervosa

Women Healthy Controls

Eligibility Criteria

• Age: 18 Years - 35 Years
• Sex: female
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)
• Sampling Method: Non-Probability Sample

Study Population

Women (ages 18-35 years) with bulimia nervosa, and age- and BMI-matched healthy controls.

You may qualify if:

• Female
• Right-handed
• Between the ages of 18 and 35 years
• \*For Women with Bulimia Nervosa:
• Binge eating (i.e., eating a large amount of food while experiencing a sense of loss of control)
• Purging via self-induced vomiting (other methods may also be endorsed)

You may not qualify if:

• Current significant medical illness or condition (e.g., diabetes, thyroid disease)
• Pregnancy, planned pregnancy, or lactation during the study period
• Non-removable metallic objects in the body

Sponsors & Collaborators

• University of California, San Diego: lead
• National Institute of Mental Health (NIMH): collaborator
• The Hilda & Preston Davis Foundation: collaborator

Study Sites (1)

UCSD Eating Disorders Center for Treatment and Research

San Diego, California, 92121, United States

Location

MeSH Terms

Conditions

Bulimia Nervosa; Bulimia; Emotional Regulation

Condition Hierarchy (Ancestors)

Feeding and Eating Disorders; Mental Disorders; Hyperphagia; Signs and Symptoms, Digestive; Signs and Symptoms; Pathological Conditions, Signs and Symptoms; Self-Control; Social Behavior; Behavior

Study Officials

• Laura A. Berner, Ph.D.

  University of California, San Diego

  STUDY DIRECTOR

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Principal Investigator

Study Record Dates

• First Submitted: October 25, 2016
• First Posted: December 20, 2016
• Study Start: June 1, 2016
• Primary Completion: July 31, 2022
• Study Completion: July 31, 2022
• Last Updated: January 17, 2023

Record last verified: 2023-01

Locations

US (1)