Evaluation of Major Cardiovascular Events in Participants With, or at High Risk for, Cardiovascular Disease Who Are Statin Intolerant Treated With Bempedoic Acid (ETC-1002) or Placebo
CLEAR Outcomes
A Randomized, Double-blind, Placebo-controlled Study to Assess the Effects of Bempedoic Acid (ETC-1002) on the Occurrence of Major Cardiovascular Events in Patients With, or at High Risk for, Cardiovascular Disease Who Are Statin Intolerant
1 other identifier
interventional
13,970
30 countries
1284
Brief Summary
The purpose of this study is to determine if treatment with bempedoic acid (ETC-1002) versus placebo decreases the risk of cardiovascular events in participants who have or are at high risk for cardiovascular disease and are statin intolerant.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P75+ for phase_3 cardiovascular-diseases
Started Dec 2016
Typical duration for phase_3 cardiovascular-diseases
1284 active sites
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
Click on a node to explore related trials.
Study Timeline
Key milestones and dates
First Submitted
Initial submission to the registry
December 9, 2016
CompletedFirst Posted
Study publicly available on registry
December 15, 2016
CompletedStudy Start
First participant enrolled
December 22, 2016
CompletedPrimary Completion
Last participant's last visit for primary outcome
November 7, 2022
CompletedStudy Completion
Last participant's last visit for all outcomes
November 7, 2022
CompletedResults Posted
Study results publicly available
January 3, 2024
CompletedJanuary 3, 2024
December 1, 2023
5.9 years
December 9, 2016
October 25, 2023
December 13, 2023
Conditions
Outcome Measures
Primary Outcomes (1)
Number of Participants With First Occurrence of Four Component Major Adverse Cardiovascular Events (MACE)
The primary efficacy end point was a four-component composite of adjudicated MACE, defined as death from cardiovascular causes, nonfatal myocardial infarction, nonfatal stroke, or coronary revascularization, as assessed in a time-to first-event analysis.
Up to 68 months
Secondary Outcomes (6)
Number of Participants With First Occurrence of Three Component MACE
Up to 68 months
Number of Participants With First Occurrence of Myocardial Infarction
Up to 68 months
Number of Participants With Time to First Occurrence of Coronary Revascularization
Up to 68 months
Number of Participants With Time to First Occurrence of Stroke
Up to 68 months
Number of Participants With Time to Cardiovascular Death
Up to 68 months
- +1 more secondary outcomes
Study Arms (2)
Bempedoic Acid 180 mg
EXPERIMENTALBempedoic acid 180 mg tablet taken orally, once daily.
Placebo Comparator
PLACEBO COMPARATORMatching placebo tablet taken orally, once daily
Interventions
Patients take bempedoic acid 180 mg tablet orally once daily
Patients take matching placebo tablet orally once daily
Eligibility Criteria
You may qualify if:
- Age between 18 and 85 years
- History of, or at high risk for, cardiovascular disease (CVD) including coronary artery disease, symptomatic peripheral arterial disease, cerebrovascular atherosclerotic disease, or at high risk for a cardiovascular event
- Participant-reported SI due to an adverse safety effect that started or increased during statin therapy and resolved or improved when statin therapy was discontinued resulting in an inability to tolerate:
- or more statins at any dose, or
- statin at any dose and unwilling to attempt a second statin or advised by a physician to not attempt a second statin.
- Please note that participants currently tolerating very low dose statin therapy (an average daily dose of rosuvastatin \<5 mg, atorvastatin \<10 mg, simvastatin \<10 mg, lovastatin \<20 mg, pravastatin \<40 mg, fluvastatin \<40 mg, or pitavastatin \<2 mg) are considered to be intolerant to that low dose statin. Patients may continue taking very low dose statin therapy throughout the study provided that it is stable (used for at least 4 weeks prior to screening) and well tolerated.
- Written confirmation by both participant and investigator that the participant is statin intolerant as defined above, aware of the benefit of statin use to reduce the risk of MACE including death, and also aware that many other participants who are unable to tolerate a statin are able to tolerate a different statin or dose.
- Men and nonpregnant, nonlactating women
- Fasting blood LDL-cholesterol ≥ 100 (2.6 mmol/L) at screening
You may not qualify if:
- Fasting blood triglycerides greater than 500 mg/dL (5.6 mmol/L) at screening
- Recent (within 90 days of screening) history of major cardiovascular events, transient ischemic attack (TIA), or unstable or symptomatic cardiac arrhythmia
- History of severe heart failure
- Uncontrolled hypertension or uncontrolled diabetes
Contact the study team to confirm eligibility.
Sponsors & Collaborators
- Esperion Therapeutics, Inc.lead
- The Cleveland Cliniccollaborator
Study Sites (1319)
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Birmingham, Alabama, 35211, United States
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Birmingham, Alabama, 35235, United States
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Huntsville, Alabama, 35802, United States
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Mobile, Alabama, 36608, United States
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Mobile, Alabama, 36617, United States
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Pell City, Alabama, 35125, United States
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Tuscumbia, Alabama, 35674, United States
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Chandler, Arizona, 85224, United States
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Cottonwood, Arizona, 86326, United States
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Fountain Hills, Arizona, 85268, United States
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Gilbert, Arizona, 85295, United States
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Glendale, Arizona, 85306, United States
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Glendale, Arizona, 85308, United States
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Mesa, Arizona, 85206, United States
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Phoenix, Arizona, 85020, United States
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Phoenix, Arizona, 85050, United States
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Tucson, Arizona, 85712, United States
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Tucson, Arizona, 85741, United States
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Beverly Hills, California, 90211, United States
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Carlsbad, California, 92008, United States
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Huntington Beach, California, 92648-1717, United States
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Lincoln, California, 95648, United States
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Long Beach, California, 90806, United States
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Long Beach, California, 90807, United States
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Northridge, California, 91324, United States
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Oceanside, California, 92056, United States
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Rancho Cucamonga, California, 91730, United States
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San Diego, California, 92108, United States
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Santa Ana, California, 92705, United States
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Santa Rosa, California, 95405, United States
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Torrance, California, 90509, United States
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Vista, California, 92083, United States
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Aurora, Colorado, 80012, United States
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Colorado Springs, Colorado, 80909, United States
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Colorado Springs, Colorado, 80922, United States
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Golden, Colorado, 80401, United States
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Littleton, Colorado, 80120, United States
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Loveland, Colorado, 80538, United States
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Hamden, Connecticut, 06517, United States
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Hartford, Connecticut, 06102, United States
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North Haven, Connecticut, 06473, United States
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Stamford, Connecticut, 06905, United States
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Boca Raton, Florida, 33434, United States
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Boynton Beach, Florida, 33435, United States
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Boynton Beach, Florida, 33472, United States
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Bradenton, Florida, 34209, United States
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Clearwater, Florida, 33756, United States
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Crystal River, Florida, 34429, United States
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Fleming Island, Florida, 32003, United States
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Fort Lauderdale, Florida, 33008, United States
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Fort Lauderdale, Florida, 33308, United States
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Greenacres City, Florida, 33467, United States
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Hialeah, Florida, 33010, United States
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Hialeah, Florida, 33012, United States
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Inverness, Florida, 34452, United States
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Jacksonville, Florida, 32205, United States
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Jacksonville, Florida, 32216, United States
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Jacksonville, Florida, 32277, United States
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Jupiter, Florida, 33458, United States
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Lake Worth, Florida, 33461, United States
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Largo, Florida, 33770, United States
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Largo, Florida, 33777, United States
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Melbourne, Florida, 32934, United States
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Miami, Florida, 33125, United States
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Miami, Florida, 33126, United States
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Miami, Florida, 33133, United States
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Miami, Florida, 33144, United States
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Miami, Florida, 33165, United States
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Miami, Florida, 33172, United States
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Miami, Florida, 33173, United States
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Miami, Florida, 33175, United States
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Miami, Florida, 33186, United States
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Miami Lakes, Florida, 33016, United States
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Naples, Florida, 34102, United States
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New Port Richey, Florida, 34655, United States
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North Miami Beach, Florida, 33162, United States
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Ocala, Florida, 34471, United States
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Orlando, Florida, 32825, United States
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Ormond Beach, Florida, 32174, United States
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Pembroke Pines, Florida, 33025, United States
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Pembroke Pines, Florida, 33026, United States
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Pembroke Pines, Florida, 33027, United States
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Pinellas Park, Florida, 33781, United States
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Ponte Vedra, Florida, 32081, United States
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Port Charlotte, Florida, 33952, United States
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Safety Harbor, Florida, 34695, United States
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St. Petersburg, Florida, 33713, United States
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Tampa, Florida, 33624, United States
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Wellington, Florida, 33449, United States
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Atlanta, Georgia, 30322, United States
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Columbus, Georgia, 31904, United States
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Covington, Georgia, 30014, United States
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Cumming, Georgia, 30041, United States
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Dunwoody, Georgia, 30338, United States
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Gainesville, Georgia, 30501, United States
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Macon, Georgia, 31201, United States
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Savannah, Georgia, 31406, United States
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Tucker, Georgia, 30084, United States
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Woodstock, Georgia, 30189, United States
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Meridian, Idaho, 83646, United States
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Champaign, Illinois, 61820, United States
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Chicago, Illinois, 60602, United States
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Gurnee, Illinois, 60031, United States
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Jerseyville, Illinois, 62052, United States
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Olympia Fields, Illinois, 60461, United States
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Rock Island, Illinois, 61201, United States
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Rockford, Illinois, 61107, United States
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Anderson, Indiana, 46011, United States
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Elkhart, Indiana, 46514-2487, United States
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Evansville, Indiana, 47714, United States
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Evansville, Indiana, 47715, United States
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Indianapolis, Indiana, 46237, United States
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Indianapolis, Indiana, 46290, United States
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Munster, Indiana, 46321, United States
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Richmond, Indiana, 47374, United States
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Council Bluffs, Iowa, 51501, United States
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Iowa City, Iowa, 52242, United States
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Waterloo, Iowa, 50702, United States
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West Des Moines, Iowa, 50266, United States
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Hutchinson, Kansas, 67502, United States
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Kansas City, Kansas, 66160, United States
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Wichita, Kansas, 67205-1138, United States
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Elizabethtown, Kentucky, 42701, United States
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Lexington, Kentucky, 40503, United States
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Louisville, Kentucky, 40213, United States
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Paducah, Kentucky, 42003, United States
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Eunice, Louisiana, 70535, United States
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Lake Charles, Louisiana, 70601, United States
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New Orleans, Louisiana, 70121, United States
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New Orleans, Louisiana, 70124, United States
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West Monroe, Louisiana, 71291, United States
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Annapolis, Maryland, 21401, United States
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Baltimore, Maryland, 21218, United States
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Baltimore, Maryland, 21228, United States
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Baltimore, Maryland, 21229, United States
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Baltimore, Maryland, 21237, United States
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Columbia, Maryland, 21044, United States
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Rockville, Maryland, 20850, United States
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Salisbury, Maryland, 21804, United States
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Towson, Maryland, 21204, United States
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Haverhill, Massachusetts, 01830, United States
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Hyannis, Massachusetts, 02601, United States
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Buckley, Michigan, 49620, United States
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Cadillac, Michigan, 49601, United States
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Caro, Michigan, 48723, United States
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Grand Blanc, Michigan, 48439, United States
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Grand Rapids, Michigan, 49546, United States
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Kalamazoo, Michigan, 49009, United States
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Lansing, Michigan, 48910, United States
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Lansing, Michigan, 48912, United States
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Mount Clemens, Michigan, 48043, United States
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Petoskey, Michigan, 49770, United States
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Saginaw, Michigan, 48601, United States
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Sterling Heights, Michigan, 48312, United States
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Troy, Michigan, 48085, United States
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Minneapolis, Minnesota, 55455, United States
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Richfield, Minnesota, 55432, United States
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Saint Cloud, Minnesota, 56303-1900, United States
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Saint Paul, Minnesota, 55101, United States
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Saint Paul, Minnesota, 55102, United States
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Tupelo, Mississippi, 38801, United States
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Bridgeton, Missouri, 63044, United States
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St Louis, Missouri, 63128, United States
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St Louis, Missouri, 63141, United States
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Kalispell, Montana, 59901, United States
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Fremont, Nebraska, 68025, United States
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Lincoln, Nebraska, 68526, United States
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Omaha, Nebraska, 68144, United States
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Henderson, Nevada, 89052, United States
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Las Vegas, Nevada, 89119, United States
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Nashua, New Hampshire, 03060, United States
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Bridgeton, New Jersey, 08302, United States
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Bridgewater, New Jersey, 08807, United States
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Flemington, New Jersey, 08822, United States
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Haddon, New Jersey, 08035, United States
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Linden, New Jersey, 07036, United States
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Sewell, New Jersey, 08080, United States
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Teaneck, New Jersey, 07666, United States
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Albany, New York, 12211, United States
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Binghamton, New York, 13901, United States
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Bronxville, New York, 10708, United States
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Buffalo, New York, 14215, United States
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Endwell, New York, 13760, United States
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Jackson Heights, New York, 11372, United States
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Jamaica, New York, 11432, United States
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Manhasset, New York, 11030, United States
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New Windsor, New York, 12553, United States
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New York, New York, 10029, United States
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New York, New York, 10036, United States
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Poughkeepsie, New York, 12601, United States
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Saratoga Springs, New York, 12866, United States
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Southampton, New York, 11968, United States
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Asheboro, North Carolina, 27203, United States
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Burlington, North Carolina, 27215, United States
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Cary, North Carolina, 27511, United States
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Cary, North Carolina, 27518, United States
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Charlotte, North Carolina, 28204, United States
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Greensboro, North Carolina, 27401, United States
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Greensboro, North Carolina, 27408, United States
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Greensboro, North Carolina, 27410, United States
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Hickory, North Carolina, 28601, United States
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Lenoir, North Carolina, 28645, United States
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Mooresville, North Carolina, 28117, United States
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Morehead City, North Carolina, 28557, United States
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Raleigh, North Carolina, 27609, United States
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Rocky Mount, North Carolina, 27804, United States
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Rocky Mount, North Carolina, 28404, United States
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Sanford, North Carolina, 27330, United States
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Wilmington, North Carolina, 28401, United States
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Winston-Salem, North Carolina, 27157, United States
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Fargo, North Dakota, 58103, United States
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Akron, Ohio, 44304, United States
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Akron, Ohio, 44311, United States
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Canton, Ohio, 44710, United States
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Cincinnati, Ohio, 45236, United States
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Cleveland, Ohio, 44109, United States
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Cleveland, Ohio, 44195, United States
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Columbus, Ohio, 43210, United States
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Columbus, Ohio, 43212, United States
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Dayton, Ohio, 45419, United States
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Franklin, Ohio, 45005, United States
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Marion, Ohio, 43302, United States
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Maumee, Ohio, 43537, United States
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Middleburg Heights, Ohio, 44130, United States
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Norman, Oklahoma, 73069, United States
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Oklahoma City, Oklahoma, 73111, United States
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Oklahoma City, Oklahoma, 73120, United States
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Oklahoma City, Oklahoma, 73134, United States
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Oklahoma City, Oklahoma, 73135, United States
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Tulsa, Oklahoma, 74133, United States
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Abington, Pennsylvania, 19001, United States
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Beaver, Pennsylvania, 15009, United States
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Camp Hill, Pennsylvania, 17011, United States
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Johnstown, Pennsylvania, 15905, United States
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McMurray, Pennsylvania, 15317, United States
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Natrona Heights, Pennsylvania, 15065, United States
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Pittsburgh, Pennsylvania, 15236, United States
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Smithfield, Pennsylvania, 15478, United States
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Uniontown, Pennsylvania, 15401, United States
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York, Pennsylvania, 17403, United States
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Cumberland, Rhode Island, 02864, United States
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Providence, Rhode Island, 02906, United States
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Anderson, South Carolina, 29621-2062, United States
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Anderson, South Carolina, 29621, United States
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Charleston, South Carolina, 29407, United States
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Charleston, South Carolina, 29425, United States
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Greer, South Carolina, 29651, United States
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Little River, South Carolina, 29566, United States
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Old Point Station, South Carolina, 29707, United States
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Summerville, South Carolina, 29485, United States
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Rapid City, South Dakota, 57701, United States
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Rapid City, South Dakota, 57702, United States
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Fayetteville, Tennessee, 37334, United States
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Greeneville, Tennessee, 37745, United States
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Jackson, Tennessee, 38301, United States
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Knoxville, Tennessee, 37918, United States
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Allen, Texas, 75013, United States
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Amarillo, Texas, 79106, United States
Seton Heart Institute
Austin, Texas, 78705, United States
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Dallas, Texas, 75226, United States
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Dallas, Texas, 75231, United States
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Dallas, Texas, 75234, United States
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Dallas, Texas, 75235, United States
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DeSoto, Texas, 75115, United States
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Fort Worth, Texas, 76107, United States
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Fort Worth, Texas, 76132, United States
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Houston, Texas, 77008, United States
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Houston, Texas, 77030, United States
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Houston, Texas, 77054, United States
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Houston, Texas, 77074, United States
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Katy, Texas, 77450, United States
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Kerrville, Texas, 78028, United States
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Lubbock, Texas, 79410, United States
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McKinney, Texas, 75017, United States
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Odessa, Texas, 79761, United States
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Pearland, Texas, 77584, United States
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Plano, Texas, 75024, United States
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Plano, Texas, 75093, United States
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San Angelo, Texas, 76904, United States
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San Antonio, Texas, 78229, United States
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San Antonio, Texas, 78230, United States
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Schertz, Texas, 78154, United States
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Sugar Land, Texas, 77479, United States
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Tomball, Texas, 77375, United States
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Tyler, Texas, 75701, United States
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Victoria, Texas, 77901, United States
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Farmington, Utah, 84025, United States
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Layton, Utah, 84041, United States
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Murray, Utah, 84123, United States
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Orem, Utah, 84058, United States
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Burke, Virginia, 22015, United States
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Charlottesville, Virginia, 22903, United States
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Danville, Virginia, 24541, United States
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Falls Church, Virginia, 22042, United States
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Hampton, Virginia, 23666, United States
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Norfolk, Virginia, 23510, United States
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Roanoke, Virginia, 24014, United States
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Suffolk, Virginia, 23435, United States
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Woodbridge, Virginia, 22192, United States
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Bellevue, Washington, 98004, United States
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Green Bay, Wisconsin, 54301, United States
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Kenosha, Wisconsin, 53144, United States
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La Crosse, Wisconsin, 54601, United States
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Madison, Wisconsin, 53713, United States
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Bahía Blanca, Buenos Aires, 8000, Argentina
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Bahía Blanca, Buenos Aires, B8000FTD, Argentina
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Bahía Blanca, Buenos Aires, B8001HXM, Argentina
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Berazategui, Buenos Aires, 1884, Argentina
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Ciudad Autónoma de Buenos Aires, Buenos Aires, 1426, Argentina
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Ciudad Autónoma de Buenos Aires, Buenos Aires, C1179AAB, Argentina
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Coronel Suárez, Buenos Aires, B7540GHD, Argentina
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Haedo, Buenos Aires, B1706CZA, Argentina
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La Plata, Buenos Aires, B1900AXI, Argentina
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Mar del Plata, Buenos Aires, B7600FYK, Argentina
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Mar del Plata, Buenos Aires, B7600FZ, Argentina
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Mar del Plata, Buenos Aires, B7600GNY, Argentina
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Mar del Plata, Buenos Aires, B7602CBM, Argentina
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Morón, Buenos Aires, 1708, Argentina
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San Fernando, Buenos Aires, B1646EBJ, Argentina
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San Martín, Buenos Aires, B1650CSQ, Argentina
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Vicente López, Buenos Aires, 1602, Argentina
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Zárate, Buenos Aires, B2800DGH, Argentina
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Villa Luro, Ciudad Autonoma Buenos Aires, C1440CFD, Argentina
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Caba, Ciudad Autonoma, C1419GEP, Argentina
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Ciudad Autónoma de Buenos Aire, Ciudad Autonoma, C1093AAS, Argentina
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Ciudad Autónoma de Buenos Aire, Ciudad Autonoma, C1119ACN, Argentina
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Ciudad Autónoma de Buenos Aire, Ciudad Autonoma, C1425DES, Argentina
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Ciudad Autónoma de Buenos Aire, Ciudad Autonoma, C1428ART, Argentina
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Ciudad Autónoma de Buenos Aire, Ciudad Autonoma, C1430CKE, Argentina
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Córdoba, Córdoba Province, 5000, Argentina
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Córdoba, Córdoba Province, X50000EVQ, Argentina
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Córdoba, Córdoba Province, X5003DCP, Argentina
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San Vicente, Córdoba Province, X5006CBI, Argentina
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Godoy Cruz, Mendoza Province, 5501, Argentina
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San Rafael, Mendoza Province, CP5600, Argentina
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Temperley, Partido De Lomas De Zamora, 1834, Argentina
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Rosario, Santa Fe Province, 2000, Argentina
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Rosario, Santa Fe Province, CP2000, Argentina
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Rosario, Santa Fe Province, S2000DIF, Argentina
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Rosario, Santa Fe Province, S2000DNM, Argentina
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Rosario, Sante Fe, 2000, Argentina
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San Miguel de Tucumán, Tucumán Province, T4000ICL, Argentina
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San Miguel de Tucumán, Tucumán Province, T4000, Argentina
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Buenos Aires, 1056, Argentina
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Buenos Aires, 1406, Argentina
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Buenos Aires, C1179AAB, Argentina
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Buenos Aires, C1180AAX, Argentina
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Buenos Aires, C1280AEB, Argentina
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Buenos Aires, C1405BCK, Argentina
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Buenos Aires, C1425AGC, Argentina
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Ciudad Autonoma Buenos Aires, C1118AAE, Argentina
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Ciudad Autonoma Buenos Aires, C1128AAE, Argentina
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Corrientes, 3400, Argentina
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Córdoba, 5008, Argentina
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Córdoba, 5016, Argentina
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Córdoba, X5000AAW, Argentina
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Córdoba, X5000AOQ, Argentina
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Córdoba, X5000BNB, Argentina
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Córdoba, X5000JHQ, Argentina
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Córdoba, X5003DCE, Argentina
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La Plata, B1900EHD, Argentina
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La Plata, B1902COS, Argentina
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Lanús, B1824KAJ, Argentina
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Morón, B1708GIK, Argentina
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Pilar, B1629ODT, Argentina
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Quilmes, B1878GEG, Argentina
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Ramos Mejía, B1704ETD, Argentina
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Rosario, S2000ORE, Argentina
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Rosario, S2001ODA, Argentina
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Salta, 4406, Argentina
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San Lorenzo, 2200, Argentina
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San Miguel de Tucumán, T4000ICL, Argentina
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San Miguel de Tucumán, T4000IFL, Argentina
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Santa Fe, S3000EOZ, Argentina
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Santa Fe, S3000FWO, Argentina
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Adamstown, New South Wales, 2289, Australia
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Camperdown, New South Wales, 2050, Australia
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Gosford, New South Wales, 2250, Australia
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Liverpool, New South Wales, 2170, Australia
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Merewether, New South Wales, 2291, Australia
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Tumbi Vmbi, New South Wales, 2261, Australia
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Wollongong, New South Wales, 2522, Australia
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Auchenflower, Queensland, 4066, Australia
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Bundaberg, Queensland, 4670, Australia
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Chermside, Queensland, 4032, Australia
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Milton, Queensland, 4064, Australia
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Sherwood, Queensland, 4075, Australia
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Sippy Downs, Queensland, 4556, Australia
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Woolloongabba, Queensland, 4102, Australia
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Adelaide, South Australia, 5000, Australia
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Ashford, South Australia, 5035, Australia
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Fullarton, South Australia, 5063, Australia
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Hobart, Tasmania, 7000, Australia
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Ballarat, Victoria, 3350, Australia
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Box Hill, Victoria, 3128, Australia
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Clayton, Victoria, 3168, Australia
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Fitzroy, Victoria, 3065, Australia
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Frankston, Victoria, 3199, Australia
Unknown Facility
Langwarrin, Victoria, 3910, Australia
Unknown Facility
Melbourne, Victoria, 3004, Australia
Unknown Facility
Mildura, Victoria, 3500, Australia
Unknown Facility
Joondalup, Western Australia, 6027, Australia
Unknown Facility
Murdoch, Western Australia, 6150, Australia
Unknown Facility
Nedlands, Western Australia, 6009, Australia
Unknown Facility
Perth, Western Australia, 6000, Australia
Unknown Facility
Subiaco, Western Australia, 6008, Australia
Unknown Facility
Feldkirch, 6807, Austria
Unknown Facility
Graz, 8036, Austria
Unknown Facility
Innsbruck, 6020, Austria
Unknown Facility
Linz, 4020, Austria
Unknown Facility
Linz, 4021, Austria
Unknown Facility
Vienna, 1030, Austria
Unknown Facility
Vienna, 1060, Austria
Unknown Facility
Vienna, 1090, Austria
Unknown Facility
Vienna, 1130, Austria
Unknown Facility
Vienna, 1170, Austria
Unknown Facility
Wiener Neustadt, 2700, Austria
Unknown Facility
Aalst, 9300, Belgium
Unknown Facility
Antwerp, 2020, Belgium
Unknown Facility
Antwerp, 2060, Belgium
Unknown Facility
Brasschaat, 2930, Belgium
Unknown Facility
Bruges, 8000, Belgium
Unknown Facility
Brussels, 1070, Belgium
Unknown Facility
Brussels, 1090, Belgium
Unknown Facility
De Pinte, 9840, Belgium
Unknown Facility
Dendermonde, 9200, Belgium
Unknown Facility
Edegem, 2650, Belgium
Unknown Facility
Genk, 3600, Belgium
Unknown Facility
Ghent, 9000, Belgium
Unknown Facility
Halen, 3545, Belgium
Unknown Facility
Liège, 4000, Belgium
Unknown Facility
Mechelen, 2800, Belgium
Unknown Facility
Merksem, 2170, Belgium
Unknown Facility
Mons, 7000, Belgium
Unknown Facility
Tienen, 3300, Belgium
Unknown Facility
Turnhout, 2300, Belgium
Unknown Facility
Wetteren, 9230, Belgium
Unknown Facility
Yvoir, 5530, Belgium
Unknown Facility
Fortaleza, Ceará, 60160-230, Brazil
Unknown Facility
Fortaleza, Ceará, 60430-350, Brazil
Unknown Facility
Fortaleza, Ceará, 60430-370, Brazil
Unknown Facility
Fortaleza, Ceará, 60846-190, Brazil
Unknown Facility
Vitória, Espírito Santo, 29055-450, Brazil
Unknown Facility
Salvador, Estado de Bahia, 41950-275, Brazil
Unknown Facility
Brasília, Federal District, 70200-730, Brazil
Unknown Facility
Brasília, Federal District, 70710-100, Brazil
Unknown Facility
Brasília, Federal District, 71655-175, Brazil
Unknown Facility
Goiânia, Goiás, 74210-050, Brazil
Unknown Facility
Goiânia, Goiás, 74223-130, Brazil
Unknown Facility
Campo Grande, Mato Grosso do Sul, 79080-190, Brazil
Unknown Facility
Belo Horizonte, Minas Gerais, 30110-934, Brazil
Unknown Facility
Belo Horizonte, Minas Gerais, 30140-062, Brazil
Unknown Facility
Belo Horizonte, Minas Gerais, 30150-240, Brazil
Unknown Facility
Uberlândia, Minas Gerais, 38411-186, Brazil
Unknown Facility
Curitiba, Paraná, 80030-110, Brazil
Unknown Facility
Curitiba, Paraná, 80030-480, Brazil
Unknown Facility
Curitiba, Paraná, 80060-900, Brazil
Unknown Facility
Curitiba, Paraná, 80730-150, Brazil
Unknown Facility
Belém, Pará, 66073-000, Brazil
Unknown Facility
Recife, Pernambuco, 52051-380, Brazil
Unknown Facility
Boa Vista, Recife, 50070, Brazil
Unknown Facility
Natal, Rio Grande do Norte, 59020-500, Brazil
Unknown Facility
Passo Fundo, Rio Grande do Sul, 99010-080, Brazil
Unknown Facility
Porto Alegre, Rio Grande do Sul, 90035-170, Brazil
Unknown Facility
Porto Alegre, Rio Grande do Sul, 90510-040, Brazil
Unknown Facility
Porto Alegre, Rio Grande do Sul, 90620-001, Brazil
Unknown Facility
Porto Alegre, Rio Grande do Sul, 90840-440, Brazil
Unknown Facility
Santa Maria, Rio Grande do Sul, 97015-530, Brazil
Unknown Facility
Caxias do Sul, Rio Grande Du Sul, 95070-560, Brazil
Unknown Facility
Porto Alegre, Rio Grande Du Sul, 90020-090, Brazil
Unknown Facility
Balneário Camboriú, Santa Catarina, 88331-085, Brazil
Unknown Facility
Blumenau, Santa Catarina, 89010-906, Brazil
Unknown Facility
São Paulo, Sau Paulo, 05403-000, Brazil
Unknown Facility
Campinas, São Paulo, 13010-001, Brazil
Unknown Facility
Campinas, São Paulo, 13020-431, Brazil
Unknown Facility
Campinas, São Paulo, 13060-080, Brazil
Unknown Facility
Cotia, São Paulo, 06717-100, Brazil
Unknown Facility
Jaú, São Paulo, 17210-190, Brazil
Unknown Facility
Marília, São Paulo, 17515-000, Brazil
Unknown Facility
Paraíso, São Paulo, 4005, Brazil
Unknown Facility
Santo André, São Paulo, 09030-010, Brazil
Unknown Facility
Santo André, São Paulo, 09080-110, Brazil
Unknown Facility
Santo André, São Paulo, 09090-790, Brazil
Unknown Facility
São José do Rio Preto, São Paulo, 15015, Brazil
Unknown Facility
São José do Rio Preto, São Paulo, 15090-000, Brazil
Unknown Facility
São José dos Campos, São Paulo, 12243-280, Brazil
Unknown Facility
São Paulo, São Paulo, 01141-020, Brazil
Unknown Facility
São Paulo, São Paulo, 01221-020, Brazil
Unknown Facility
São Paulo, São Paulo, 01228-000, Brazil
Unknown Facility
São Paulo, São Paulo, 01244-030, Brazil
Unknown Facility
São Paulo, São Paulo, 01327-010, Brazil
Unknown Facility
São Paulo, São Paulo, 01406-200, Brazil
Unknown Facility
São Paulo, São Paulo, 01506-000, Brazil
Unknown Facility
São Paulo, São Paulo, 050017-000, Brazil
Unknown Facility
Tatuí, São Paulo, 18270-170, Brazil
Unknown Facility
Votuporanga, São Paulo, 15500-003, Brazil
Unknown Facility
Bela Vista, 1323, Brazil
Unknown Facility
Belo Horizonte, 30140, Brazil
Unknown Facility
Belo Horizonte, 30190, Brazil
Unknown Facility
Belo Horizonte, 31150221, Brazil
Unknown Facility
Bento Gonçalves, 95700068, Brazil
Unknown Facility
Brasília, 70658, Brazil
Unknown Facility
Curitiba, 80045, Brazil
Unknown Facility
Curitiba, 80230130, Brazil
Unknown Facility
Curitiba, 80730150, Brazil
Unknown Facility
Goiânia, 74093, Brazil
Unknown Facility
Joinville, 89227, Brazil
Unknown Facility
Maceió, 57051, Brazil
Unknown Facility
Maringá, 87015001, Brazil
Unknown Facility
Marília, 17515, Brazil
Unknown Facility
Porto Alegre, 90035, Brazil
Unknown Facility
Porto Alegre, 91350200, Brazil
Unknown Facility
Rio de Janeiro, 22271-100, Brazil
Unknown Facility
Salvador, 40050, Brazil
Unknown Facility
Salvador, 40110, Brazil
Unknown Facility
Salvador, 40170, Brazil
Unknown Facility
Salvador, 41820, Brazil
Unknown Facility
Santa Maria, 97105, Brazil
Unknown Facility
São José, 88103, Brazil
Unknown Facility
São Luís, 65077357, Brazil
Unknown Facility
São Paulo, 08270-070, Brazil
Unknown Facility
São Paulo, 0, Brazil
Unknown Facility
Blagoevgrad, 2700, Bulgaria
Unknown Facility
Byala, 7100, Bulgaria
Unknown Facility
Dimitrovgrad, 6400, Bulgaria
Unknown Facility
Haskovo, 6300, Bulgaria
Unknown Facility
Pazardzhik, 4400, Bulgaria
Unknown Facility
Pernik, 2300, Bulgaria
Unknown Facility
Pleven, 5800, Bulgaria
Unknown Facility
Plovdiv, 4000, Bulgaria
Unknown Facility
Plovdiv, 4002, Bulgaria
Unknown Facility
Rousse, 7000, Bulgaria
Unknown Facility
Rousse, 7013, Bulgaria
Unknown Facility
Sandanski, 2800, Bulgaria
Unknown Facility
Sliven, 8800, Bulgaria
Unknown Facility
Sofia, 1040, Bulgaria
Unknown Facility
Sofia, 1202, Bulgaria
Unknown Facility
Sofia, 1233, Bulgaria
Unknown Facility
Sofia, 1309, Bulgaria
Unknown Facility
Sofia, 1336, Bulgaria
Unknown Facility
Sofia, 1407, Bulgaria
Unknown Facility
Sofia, 1408, Bulgaria
Unknown Facility
Sofia, 1431, Bulgaria
Unknown Facility
Sofia, 1527, Bulgaria
Unknown Facility
Sofia, 1606, Bulgaria
Unknown Facility
Sofia, 1680, Bulgaria
Unknown Facility
Sofia, 1750, Bulgaria
Unknown Facility
Sofia, 1784, Bulgaria
Unknown Facility
Stara Zagora, 6000, Bulgaria
Unknown Facility
Stara Zagora, 6004, Bulgaria
Unknown Facility
Varna, 9000, Bulgaria
Unknown Facility
Varna, 9002, Bulgaria
Unknown Facility
Varna, 9020, Bulgaria
Unknown Facility
Veliko Tarnovo, 5000, Bulgaria
Unknown Facility
Yambol, 8600, Bulgaria
Unknown Facility
Victoria, British Columbia, V8T 5G4, Canada
Unknown Facility
Mount Pearl, Newfoundland and Labrador, A1N 1W7, Canada
Unknown Facility
Brampton, Ontario, L6T 0G1, Canada
Unknown Facility
Brampton, Ontario, L6Z 4N5, Canada
Unknown Facility
Cambridge, Ontario, N1R 6V6, Canada
Unknown Facility
Cambridge, Ontario, N1R 7R1, Canada
Unknown Facility
Greater Sudbury, Ontario, P3E 5M4, Canada
Unknown Facility
London, Ontario, N5W 6A2, Canada
Unknown Facility
Newmarket, Ontario, L3Y 5G8, Canada
Unknown Facility
Oakville, Ontario, L6K 3W7, Canada
Unknown Facility
Peterborough, Ontario, K9J 0B2, Canada
Unknown Facility
Sarnia, Ontario, N7T 4X3, Canada
Unknown Facility
Toronto, Ontario, M9V 4B4, Canada
Unknown Facility
Chicoutimi, Quebec, G7H 7K9, Canada
Unknown Facility
Longueuil, Quebec, J4M 2X1, Canada
Unknown Facility
Longueuil, Quebec, J4N 2H4, Canada
Unknown Facility
Montreal, Quebec, H1T 1C8, Canada
Unknown Facility
Montreal, Quebec, H1T 3Y7, Canada
Unknown Facility
Pointe-Claire, Quebec, H9R 3J1, Canada
Unknown Facility
Saint-Georges, Quebec, G5Y 4T8, Canada
Unknown Facility
Saint-Jean-sur-Richelieu, Quebec, J3A 1J2, Canada
Unknown Facility
Saint-Jérôme, Quebec, J7Z 5T3, Canada
Unknown Facility
Victoriaville, Quebec, G6P 6P6, Canada
Unknown Facility
Québec, G1G 3Y8, Canada
Unknown Facility
Québec, G1V 4G5, Canada
Unknown Facility
San Bernardo, 8071064, Chile
Unknown Facility
Santiago, 00000, Chile
Unknown Facility
Santiago, 7500000, Chile
Unknown Facility
Santiago, 7500739, Chile
Unknown Facility
Santiago, 8150000, Chile
Unknown Facility
Santiago, 8331143, Chile
Unknown Facility
Santiago, 8910131, Chile
Unknown Facility
Temuco, 4781156, Chile
Unknown Facility
Viña del Mar, 2520997, Chile
Unknown Facility
Barranquilla, 0000, Colombia
Unknown Facility
Barranquilla, 080020, Colombia
Unknown Facility
Barranquilla, 80020, Colombia
Unknown Facility
Bogotá, 1013, Colombia
Unknown Facility
Bogotá, 110221, Colombia
Unknown Facility
Bogotá, 110911, Colombia
Unknown Facility
Bogotá, 111111, Colombia
Unknown Facility
Bogotá, 111211, Colombia
Unknown Facility
Bucaramanga, 00000, Colombia
Unknown Facility
Bucaramanga, 681004, Colombia
Unknown Facility
Cali, 760035, Colombia
Unknown Facility
Cali, 760036, Colombia
Unknown Facility
Cartagena, 130010, Colombia
Unknown Facility
Cartagena, 13001, Colombia
Unknown Facility
Espinal, 00000, Colombia
Unknown Facility
Ibagué, 730006, Colombia
Unknown Facility
Manizales, 170004, Colombia
Unknown Facility
Medellín, 00000, Colombia
Unknown Facility
Medellín, 050021, Colombia
Unknown Facility
Pereira, 00000, Colombia
Unknown Facility
San Gil, 00000, Colombia
Unknown Facility
Zipaquirá, 250252, Colombia
Unknown Facility
Čakovec, 40000, Croatia
Unknown Facility
Dubrovnik, 20000, Croatia
Unknown Facility
Koprivnica, 48000, Croatia
Unknown Facility
Krapinske Toplice, 49217, Croatia
Unknown Facility
Opatija, 51410, Croatia
Unknown Facility
Osijek, 31000, Croatia
Unknown Facility
Rijeka, 51000, Croatia
Unknown Facility
Slavonski Brod, 35000, Croatia
Unknown Facility
Varaždin, 42000, Croatia
Unknown Facility
Virovitica, 33000, Croatia
Unknown Facility
Zabok, 49210, Croatia
Unknown Facility
Zadar, 23000, Croatia
Unknown Facility
Zagreb, 10000, Croatia
Unknown Facility
Benátky nad Jizerou, 294 71, Czechia
Unknown Facility
Beroun, 266 01, Czechia
Unknown Facility
Brandýs nad Labem, 25001, Czechia
Unknown Facility
Brno, 603 00, Czechia
Unknown Facility
Brno, 636 00, Czechia
Unknown Facility
Brno, 638 00, Czechia
Unknown Facility
Brno, 639 00, Czechia
Unknown Facility
Brno, 656 91, Czechia
Unknown Facility
Broumov, 550 01, Czechia
Unknown Facility
Choceň, 56501, Czechia
Unknown Facility
Chrudim, 53701, Czechia
Unknown Facility
Frýdek-Místek, 73801, Czechia
Unknown Facility
Havířov, 763 01, Czechia
Unknown Facility
Havlíčkův Brod, 580 22, Czechia
Unknown Facility
Hodonín, 69501, Czechia
Unknown Facility
Hradec Králové, 500 02, Czechia
Unknown Facility
Hradec Králové, 50005, Czechia
Unknown Facility
Kolín, 28000, Czechia
Unknown Facility
Náchod, 547 01, Czechia
Unknown Facility
Olomouc, 77900, Czechia
Unknown Facility
Ostrava, 70200, Czechia
Unknown Facility
Pardubice, 530 02, Czechia
Unknown Facility
Prague, 10100, Czechia
Unknown Facility
Prague, 11000, Czechia
Unknown Facility
Prague, 120 00, Czechia
Unknown Facility
Prague, 128 00, Czechia
Unknown Facility
Prague, 140 21, Czechia
Unknown Facility
Prague, 150 06, Czechia
Unknown Facility
Prague, 158 00, Czechia
Unknown Facility
Praha 4 - Krc, 140 59, Czechia
Unknown Facility
Přerov, 75002, Czechia
Unknown Facility
Slaný, 274 01, Czechia
Unknown Facility
Teplice, 41501, Czechia
Unknown Facility
Trutnov, 541 01, Czechia
Unknown Facility
Uherské Hradiště, 68601, Czechia
Unknown Facility
Aalborg, 9000, Denmark
Unknown Facility
Aalborg, 9100, Denmark
Unknown Facility
Århus N, 8200, Denmark
Unknown Facility
Ballerup Municipality, 2750, Denmark
Unknown Facility
Copenhagen NV, 2400, Denmark
Unknown Facility
Esbjerg, 6700, Denmark
Unknown Facility
Glostrup Municipality, 2600, Denmark
Unknown Facility
Hellerup, 2900, Denmark
Unknown Facility
Holbæk, 4300, Denmark
Unknown Facility
Nykøbing Falster, 4800, Denmark
Unknown Facility
Vejle, 7100, Denmark
Unknown Facility
Viborg, 8800, Denmark
Unknown Facility
Tallinn, 10117, Estonia
Unknown Facility
Tallinn, 10128, Estonia
Unknown Facility
Tallinn, 10138, Estonia
Unknown Facility
Tallinn, 13419, Estonia
Unknown Facility
Bad Krozingen, Baden-Wurttemberg, 79189, Germany
Unknown Facility
Dresden, Baden-Wurttemberg, 01307, Germany
Unknown Facility
Heidelberg, Baden-Wurttemberg, 69115, Germany
Unknown Facility
Munich, Bavaria, 80809, Germany
Unknown Facility
Wallerfing, Bavaria, 94574, Germany
Unknown Facility
Bad Homburg, Hesse, 61348, Germany
Unknown Facility
Frankfurt am Main, Hesse, 60313, Germany
Unknown Facility
Frankfurt am Main, Hesse, 60594, Germany
Unknown Facility
Frankfurt am Main, Hesse, 65929, Germany
Unknown Facility
Kassel, Hesse, 34121, Germany
Unknown Facility
Mainz, Hesse, 55128, Germany
Unknown Facility
Rodgau, Hesse, 63110, Germany
Unknown Facility
Schwerin, Mecklenburg-Vorpommern, 19055, Germany
Unknown Facility
Bielefeld, North Rhine-Westphalia, 33604, Germany
Unknown Facility
Bochum, North Rhine-Westphalia, 44787, Germany
Unknown Facility
Cologne, North Rhine-Westphalia, 50937, Germany
Unknown Facility
Cologne, North Rhine-Westphalia, 51069, Germany
Unknown Facility
Dortmund, North Rhine-Westphalia, 44137, Germany
Unknown Facility
Dortmund, North Rhine-Westphalia, 44141, Germany
Unknown Facility
Essen, North Rhine-Westphalia, 45355, Germany
Unknown Facility
Essen, North Rhine-Westphalia, 45359, Germany
Unknown Facility
Goch, North Rhine-Westphalia, 47574, Germany
Unknown Facility
Siegen, North Rhine-Westphalia, 57072, Germany
Unknown Facility
Soest, North Rhine-Westphalia, 59494, Germany
Unknown Facility
Witten, North Rhine-Westphalia, 58455, Germany
Unknown Facility
Mainz, Rhineland-Palatinate, 55131, Germany
Unknown Facility
Altenburg, Saxony, 04600, Germany
Unknown Facility
Böhlen, Saxony, 04564, Germany
Unknown Facility
Dippoldiswalde, Saxony, 01744, Germany
Unknown Facility
Dresden, Saxony, 01099, Germany
Unknown Facility
Dresden, Saxony, 01277, Germany
Unknown Facility
Dresden, Saxony, 01279, Germany
Unknown Facility
Dresden, Saxony, 01307, Germany
Unknown Facility
Leipzig, Saxony, 04103, Germany
Unknown Facility
Leipzig, Saxony, 04249, Germany
Unknown Facility
Markkleeberg, Saxony, 04416, Germany
Unknown Facility
Wermsdorf, Saxony, 04779, Germany
Unknown Facility
Zwenkau, Saxony, 04442, Germany
Unknown Facility
Bad Homburg, 61348, Germany
Unknown Facility
Berlin, 10115, Germany
Unknown Facility
Berlin, 10117, Germany
Unknown Facility
Berlin, 10409, Germany
Unknown Facility
Berlin, 10629, Germany
Unknown Facility
Berlin, 10787, Germany
Unknown Facility
Berlin, 12627, Germany
Unknown Facility
Berlin, 13597, Germany
Unknown Facility
Bielefeld, 33604, Germany
Unknown Facility
Falkensee, 14612, Germany
Unknown Facility
Frankfurt, 60389, Germany
Unknown Facility
Hamburg, 22041, Germany
Unknown Facility
Hamburg, 22143, Germany
Unknown Facility
Hamburg, 22607, Germany
Unknown Facility
Hanover, 30159, Germany
Unknown Facility
Heidelberg, 69120, Germany
Unknown Facility
Mainz, D-55128, Germany
Unknown Facility
Reinfeld, 23858, Germany
Unknown Facility
Orosháza, Szentetornya, 5905, Hungary
Unknown Facility
Baja, 6500, Hungary
Unknown Facility
Balatonfüred, H-8230, Hungary
Unknown Facility
Balatongyörök, 8313, Hungary
Unknown Facility
Békéscsaba, 5600, Hungary
Unknown Facility
Budapest, 1033, Hungary
Unknown Facility
Budapest, 1036, Hungary
Unknown Facility
Budapest, 1037, Hungary
Unknown Facility
Budapest, 1083, Hungary
Unknown Facility
Budapest, 1085, Hungary
Unknown Facility
Budapest, 1097, Hungary
Unknown Facility
Budapest, 1121, Hungary
Unknown Facility
Budapest, 1122, Hungary
Unknown Facility
Budapest, 1125, Hungary
Unknown Facility
Budapest, 1132, Hungary
Unknown Facility
Budapest, 1134, Hungary
Unknown Facility
Budapest, 1135, Hungary
Unknown Facility
Debrecen, 4025, Hungary
Unknown Facility
Debrecen, 4032, Hungary
Unknown Facility
Dombóvár, 7200, Hungary
Unknown Facility
Gyöngyös, 3200, Hungary
Unknown Facility
Győr, 9024, Hungary
Unknown Facility
Gyula, 5700, Hungary
Unknown Facility
Hajdúszoboszló, 4200, Hungary
Unknown Facility
Kalocsa, 6300, Hungary
Unknown Facility
Kecskemét, 8000, Hungary
Unknown Facility
Kiskunhalas, 6400, Hungary
Unknown Facility
Miskolc, 3530, Hungary
Unknown Facility
Mosonmagyaróvár, H-9200, Hungary
Unknown Facility
Nagykanizsa, 8800, Hungary
Unknown Facility
Nyíregyháza, 4400, Hungary
Unknown Facility
Nyíregyháza, H-4405, Hungary
Unknown Facility
Orosháza, 5905, Hungary
Unknown Facility
Pécs, 7623, Hungary
Unknown Facility
Pécs, 7635, Hungary
Unknown Facility
Polgár, 4090, Hungary
Unknown Facility
Szekszárd, 7100, Hungary
Unknown Facility
Szentendre, 2000, Hungary
Unknown Facility
Szentes, 6600, Hungary
Unknown Facility
Székesfehérvár, 8000, Hungary
Unknown Facility
Szombathely, 9700, Hungary
Unknown Facility
Zalaegerszeg, 8900, Hungary
Unknown Facility
Hyderabad, Andhra Pradesh, 500034, India
Unknown Facility
Guwahati, Assam, 781006, India
Unknown Facility
Ahmedabad, Gujarat, 380007, India
Unknown Facility
Nadiād, Gujarat, 387002, India
Unknown Facility
Surat, Gujarat, 395002, India
Unknown Facility
Surat, Gujarat, 395009, India
Unknown Facility
Vadodara, Gujarat, 391740, India
Unknown Facility
Faridabad, Haryana, 121001, India
Unknown Facility
Gurgaon, Haryana, 122001, India
Unknown Facility
Bangalore, Karnataka, 560010, India
Unknown Facility
Bangalore, Karnataka, 560099, India
Unknown Facility
Belagavi, Karnataka, 590010, India
Unknown Facility
Bengaluru, Karnataka, 560074, India
Unknown Facility
Hubli, Karnatak, 580021, India
Unknown Facility
Aurangabad, Maharashtra, 431001, India
Unknown Facility
Aurangabad, Maharashtra, 431005, India
Unknown Facility
Nagpur, Maharashtra, 440003, India
Unknown Facility
Nagpur, Maharashtra, 440010, India
Unknown Facility
Nagpur, Maharashtra, 440012, India
Unknown Facility
Nashik, Maharashtra, 422005, India
Unknown Facility
Nashik, Maharashtra, 422007, India
Unknown Facility
Pune, Maharashtra, 411001, India
Unknown Facility
Pune, Maharashtra, 411004, India
Unknown Facility
Pune, Maharashtra, 411005, India
Unknown Facility
New Delhi, National Capital Territory of Delhi, 110002, India
Unknown Facility
New Delhi, National Capital Territory of Delhi, 110005, India
Unknown Facility
New Delhi, National Capital Territory of Delhi, 110070, India
Unknown Facility
Jaipur, Rajasthan, 302001, India
Unknown Facility
Jaipur, Rajasthan, 302020, India
Unknown Facility
Chennai, Tamil Nadu, 600037, India
Unknown Facility
Coimbatore, Tamil Nadu, 641009, India
Unknown Facility
Lucknow, Uttar Pradesh, 226010, India
Unknown Facility
Noida, Uttar Pradesh, 201301, India
Unknown Facility
Kolkata, West Bengal, 700027, India
Unknown Facility
Delhi, 110062, India
Unknown Facility
Daugavpils, LV-5401, Latvia
Unknown Facility
Kuldīga, LV-3301, Latvia
Unknown Facility
Ogre, LV-5001, Latvia
Unknown Facility
Riga, LV-1010, Latvia
Unknown Facility
Riga, LV-1038, Latvia
Unknown Facility
Riga, LV1002, Latvia
Unknown Facility
Riga, LV1012, Latvia
Unknown Facility
Tukums, LV-3101, Latvia
Unknown Facility
Ventspils, LV-3601, Latvia
Unknown Facility
Alytus, 62386, Lithuania
Unknown Facility
Kaunas, 47144, Lithuania
Unknown Facility
Kaunas, 48259, Lithuania
Unknown Facility
Kaunas, 49387, Lithuania
Unknown Facility
Kaunas, 49449, Lithuania
Unknown Facility
Kaunas, LT-44001, Lithuania
Unknown Facility
Kaunas, LT-50161, Lithuania
Unknown Facility
Klaipėda, 91131, Lithuania
Unknown Facility
Šiauliai, 76231, Lithuania
Unknown Facility
Vilnius, 10323, Lithuania
Unknown Facility
Vilnius, LT-08661, Lithuania
Unknown Facility
Tijuana, Baja California Norte, 22500, Mexico
Unknown Facility
Chihuahua City, Chihuahua C.P., 31203, Mexico
Unknown Facility
Monclova, Coahuila, 25750, Mexico
Unknown Facility
Torreón, Coahuila, 27000, Mexico
Unknown Facility
Pachuca, Hidalgo, 42090, Mexico
Unknown Facility
Guadalajara, Jalisco, 44160, Mexico
Unknown Facility
Guadalajara, Jalisco, 44670, Mexico
Unknown Facility
Mexico City, Mexico City, 03100, Mexico
Unknown Facility
Mexico City, Mexico City, 03300, Mexico
Unknown Facility
Mexico City, Mexico City, 06100, Mexico
Unknown Facility
Mexico City, Mexico City, 06700, Mexico
Unknown Facility
Mexico City, Mexico City, 11650, Mexico
Unknown Facility
Monterrey, Nuevo León, 64660, Mexico
Unknown Facility
Querétaro City, Querétaro, 76000, Mexico
Unknown Facility
Culiacán, Sinaloa, 80200, Mexico
Unknown Facility
Culiacán, Sinaloa, 80230, Mexico
Unknown Facility
Mazatlán, Sinaloa, 82110, Mexico
Unknown Facility
Mérida, Yucatán, 97129, Mexico
Unknown Facility
Aguascalientes, 20010, Mexico
Unknown Facility
Aguascalientes, 20016, Mexico
Unknown Facility
Aguascalientes, 20230, Mexico
Unknown Facility
Chihuahua City, 0, Mexico
Unknown Facility
Chihuahua City, 31217, Mexico
Unknown Facility
Chihuahua City, 4032, Mexico
Unknown Facility
Cuernavaca, 62250, Mexico
Unknown Facility
Durango, 34000, Mexico
Unknown Facility
Guadalajara, 44160, Mexico
Unknown Facility
Guadalajara, 44500, Mexico
Unknown Facility
Guadalajara, 44657, Mexico
Unknown Facility
Guadalajara, 44670, Mexico
Unknown Facility
Juárez, 32472, Mexico
Unknown Facility
Mexico City, 14080, Mexico
Unknown Facility
Mexico City, 3100, Mexico
Unknown Facility
Mexico City, 3720, Mexico
Unknown Facility
Mexico City, 7760, Mexico
Unknown Facility
Monterrey, 64060, Mexico
Unknown Facility
Monterrey, 64460, Mexico
Unknown Facility
Monterrey, 64718, Mexico
Unknown Facility
Pachuca, 42070, Mexico
Unknown Facility
Puerto Vallarta, 48328, Mexico
Unknown Facility
Querétaro, 76090, Mexico
Unknown Facility
Tamaulipas, C.P 89440, Mexico
Unknown Facility
Veracruz, 91900, Mexico
Unknown Facility
Alkmaar, 1815 JD, Netherlands
Unknown Facility
Almelo, 7609 PP, Netherlands
Unknown Facility
Almere Stad, 1311 RL, Netherlands
Unknown Facility
Amersfoort, 3813 TZ, Netherlands
Unknown Facility
Amstelveen, 1186 AM, Netherlands
Unknown Facility
Amsterdam, 1034 CS, Netherlands
Unknown Facility
Amsterdam, 1066 EC, Netherlands
Unknown Facility
Amsterdam, 1081 HV, Netherlands
Unknown Facility
Amsterdam, 1091 AC, Netherlands
Unknown Facility
Amsterdam, 1105 AZ, Netherlands
Unknown Facility
Amsterdam, Netherlands
Unknown Facility
Apeldoorn, 7334 DZ, Netherlands
Unknown Facility
Apeldoorn, Netherlands
Unknown Facility
Arnhem, 6815 AD, Netherlands
Unknown Facility
Beverwijk, 1942 LE, Netherlands
Unknown Facility
Blaricum, 1261 AN, Netherlands
Unknown Facility
Delft, 2625 AD, Netherlands
Unknown Facility
Dirksland, 3247 BW, Netherlands
Unknown Facility
Doetinchem, 7009 BL, Netherlands
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Dordrecht, 3318 AT, Netherlands
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Ede, 6716 RP, Netherlands
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Eindhoven, 5623 EJ, Netherlands
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Enschede, 7512 KZ, Netherlands
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Goes, 4462 RA, Netherlands
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Gorinchem, 4204 AA, Netherlands
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Gouda, 2803 HH, Netherlands
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Gouda, 2803, Netherlands
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Hardenberg, 7772 SE, Netherlands
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Hardenberg, 7772, Netherlands
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Harderwijk, Netherlands
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Heerlen, 6419 PC, Netherlands
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Helmond, 5707 HA, Netherlands
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Hilversum, 1213 XZ, Netherlands
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Hoogeveen, 7909 AA, Netherlands
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Hoogezand, 9603 AE, Netherlands
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Hoorn, 1624 NP, Netherlands
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Leeuwarden, 8934 AD, Netherlands
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Leiden, 2333 ZA, Netherlands
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Leiderdorp, 2353 GA, Netherlands
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Maastricht, 6229 HX, Netherlands
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Nijmegen, 6525 GA, Netherlands
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Nijmegen, 6532 SZ, Netherlands
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Purmerend, 1441 RN, Netherlands
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Roosendaal, 4708 AE, Netherlands
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Rotterdam, 3037 AN, Netherlands
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Rotterdam, 3045 PM, Netherlands
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Rotterdam, 3067 GJ, Netherlands
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Rotterdam, 3079 DZ, Netherlands
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Rotterdam, 3083 AN, Netherlands
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Schiedam, 3118 JH, Netherlands
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Sneek, Netherlands
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The Hague, 2545 CH, Netherlands
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The Hague, 2565 KV, Netherlands
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The Hague, 2573 KH, Netherlands
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Tiel, 4002 WP, Netherlands
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Tilburg, 5022, Netherlands
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Utrecht, 3511 NH, Netherlands
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Utrecht, 3582 KE, Netherlands
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Utrecht, 3584 CX, Netherlands
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Venlo, 5912 BL, Netherlands
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Zutphen, 7207, Netherlands
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Zwijndrecht, 3331 LZ, Netherlands
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Zwijndrecht, 3334 SB, Netherlands
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Zwolle, 8025 AB, Netherlands
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Auckland, 0600, New Zealand
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Auckland, 0620, New Zealand
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Auckland, 0626, New Zealand
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Auckland, 1010, New Zealand
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Christchurch, 8011, New Zealand
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Christchurch, 8024, New Zealand
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Grafton, 1023, New Zealand
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Hamilton, 3200, New Zealand
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Hastings, 4120, New Zealand
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New Plymouth, 4342, New Zealand
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Papamoa, 3118, New Zealand
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Rotorua, 3010, New Zealand
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Tauranga, 3110, New Zealand
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Tauranga, 3144, New Zealand
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Wellington, 6021, New Zealand
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Włocławek, Kuyavian-Pomeranian Voivodeship, 87-800, Poland
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Krakow, Lesser Poland Voivodeship, 31-156, Poland
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Tarnów, Lesser Poland Voivodeship, 33-100, Poland
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Legnica, Lower Silesian Voivodeship, 59-220, Poland
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Wroclaw, Lower Silesian Voivodeship, 51-314, Poland
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Wroclaw, Lower Silesian Voivodeship, 53-301, Poland
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Lublin, Lubelski, 20-091, Poland
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Katowice, Silesian Voivodeship, 40-648, Poland
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Katowice, Sląskie, 40-018, Poland
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Katowice, Sląskie, 40-083, Poland
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Ruda Śląska, Sląskie, 41-709, Poland
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Bialystok, 15-445, Poland
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Brzozów, 36, Poland
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Bydgoszcz, 85-231, Poland
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Bydgoszcz, 85, Poland
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Chełm, 22-100, Poland
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Częstochowa, 42-202, Poland
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Elblag, 82-300, Poland
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Gdansk, 80-382, Poland
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Gdansk, 80-542, Poland
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Gdynia, 81-537, Poland
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Grodzisk Mazowiecki, 05-825, Poland
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Katowice, 40-040, Poland
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Katowice, 40, Poland
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Kielce, 25-364, Poland
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Krakow, 30082, Poland
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Krakow, 31-261, Poland
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Krakow, 31, Poland
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Legnica, 59, Poland
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Lodz, 15-445, Poland
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Lodz, 90-127, Poland
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Lodz, 90-302, Poland
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Lodz, 90-368, Poland
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Lodz, 90-549, Poland
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Lodz, 91-211, Poland
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Lodz, 93-513, Poland
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Lodz, 94-048, Poland
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Lublin, 20-044, Poland
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Lublin, 20-709, Poland
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Nałęczów, 24-140, Poland
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Nowa Sól, 67-100, Poland
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Nowy Targ, 34, Poland
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Oświęcim, 32-600, Poland
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Poznan, 60-702, Poland
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Poznan, 60, Poland
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Poznan, 61-655, Poland
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Puławy, 24-100, Poland
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Płock, 09-400, Poland
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Ruda Śląska, 41-709, Poland
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Ruda Śląska, 41, Poland
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Rzeszów, 35-006, Poland
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Rzeszów, 35-055, Poland
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Rzeszów, 35, Poland
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Siedlce, 08-110, Poland
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Skierniewice, 96-100, Poland
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Sopot, 81-717, Poland
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Staszów, 28-200, Poland
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Szczecin, 71-434, Poland
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Szczecin, 71-531, Poland
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Tarnów, 33, Poland
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Tczew, 83, Poland
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Torun, 87-100, Poland
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Warsaw, 00-465, Poland
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Warsaw, 01-192, Poland
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Warsaw, 02-793, Poland
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Warsaw, 04-730, Poland
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Wroclaw, 50-381, Poland
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Wroclaw, 50, Poland
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Wroclaw, 51, Poland
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Wroclaw, 53, Poland
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Włocławek, 87, Poland
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Zamość, 22-400, Poland
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Piteşti, Argeş, 110084, Romania
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Baia Mare, Maramureş, 430032, Romania
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Satu Mare, Satu Mare County, 440055, Romania
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Timișoara, Timiș County, 300456, Romania
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Alba Iulia, 510053, Romania
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Baia Mare, 430032, Romania
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Baia Mare, 430222, Romania
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Baloteşti, 077015, Romania
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Brasov, 500283, Romania
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Brasov, 500326, Romania
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Brăila, 810249, Romania
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Bucharest, 010192, Romania
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Bucharest, 010825, Romania
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Bucharest, 020045, Romania
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Bucharest, 020125, Romania
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Bucharest, 021659, Romania
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Bucharest, 030088, Romania
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Bucharest, 030463, Romania
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Bucharest, 050659, Romania
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Bucharest, 062272, Romania
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Bucharest, 10825, Romania
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Bucharest, 20063, Romania
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Bucharest, 20614, Romania
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Bucharest, 4204178, Romania
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Călăraşi, 910103, Romania
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Cluj-Napoca, 400496, Romania
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Craiova, 200500, Romania
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Deva, 330084, Romania
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Galati, 800001, Romania
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Galati, 800291, Romania
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Oradea, 410001, Romania
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Oradea, 410159, Romania
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Oradea, 410167, Romania
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Oradea, 410491, Romania
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Paşcani, 705200, Romania
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Piteşti, 110084, Romania
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Ploieşti, 100342, Romania
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Satu Mare, 440055, Romania
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Târgu Mureş, 540099, Romania
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Târgu Mureş, 540140, Romania
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Târgu Mureş, 540142, Romania
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Târgu Mureş, 540143, Romania
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Timișoara, 300362, Romania
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Timișoara, 300456, Romania
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Timișoara, 300723, Romania
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Zalău, 450112, Romania
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Barnaul, Altayskiy Kray, 656038, Russia
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Arkhangelsk, 163001, Russia
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Barnaul, 656038, Russia
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Chelyabinsk, 454021, Russia
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Chelyabinsk, 454091, Russia
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Ivanovo, 153012, Russia
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Kazan', 420012, Russia
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Kemerovo, 650000, Russia
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Kemerovo, 650002, Russia
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Kemerovo, 650055, Russia
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Kirov, 610014, Russia
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Kirov, 610027, Russia
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Kirovsk, 187340, Russia
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Krasnoyarsk, 660062, Russia
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Kursk, 305007, Russia
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Kursk, 305035, Russia
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Moscow, 109388, Russia
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Moscow, 111539, Russia
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Moscow, 115516, Russia
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Moscow, 117593, Russia
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Moscow, 119049, Russia
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Moscow, 119620, Russia
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Moscow, 121359, Russia
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Moscow, 125299, Russia
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Moscow, 125367, Russia
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Moscow, 129090, Russia
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Moscow, 129301, Russia
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Nizhny Novgorod, 603011, Russia
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Novosibirsk, 630051, Russia
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Novosibirsk, 630068, Russia
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Novosibirsk, 630089, Russia
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Novosibirsk, 630117, Russia
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Omsk, 644018, Russia
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Omsk, 644024, Russia
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Orenburg, 460000, Russia
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Perm, 614097, Russia
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Rostov-on-Don, 344068, Russia
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Ryazan, 390026, Russia
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Ryazan, 390039, Russia
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Saint Petersburg, 192148, Russia
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Saint Petersburg, 192283, Russia
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Saint Petersburg, 193318, Russia
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Saint Petersburg, 194044, Russia
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Saint Petersburg, 194156, Russia
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Saint Petersburg, 195067, Russia
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Saint Petersburg, 195220, Russia
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Saint Petersburg, 195271, Russia
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Saint Petersburg, 196084, Russia
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Saint Petersburg, 196105, Russia
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Saint Petersburg, 196601, Russia
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Saint Petersburg, 197022, Russia
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Saint Petersburg, 197341, Russia
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Saint Petersburg, 197376, Russia
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Saint Petersburg, 198205, Russia
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Saint Petersburg, 198328, Russia
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Saint Petersburg, 198510, Russia
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Saint Petersburg, 199106, Russia
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Saratov, 410012, Russia
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Sestroretsk, 197706, Russia
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Smolensk, 214019, Russia
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Tomsk, 634009, Russia
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Tomsk, 634012, Russia
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Yaroslavl, 150000, Russia
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Yaroslavl, 150030, Russia
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Yaroslavl, 150062, Russia
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Yekaterinburg, 620028, Russia
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Yekaterinburg, 620109, Russia
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Yekaterinburg, 620144, Russia
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Belgrade, 11000, Serbia
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Belgrade, 11040, Serbia
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Belgrade, 11080, Serbia
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Kragujevac, 34000, Serbia
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Niš, 18000, Serbia
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Pančevo, 26000, Serbia
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Smederevo, 11300, Serbia
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Sremska Mitrovica, 22000, Serbia
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Užice, 31000, Serbia
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Valjevo, 14000, Serbia
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Zaječar, 19000, Serbia
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Bratislava, Ružinov, 82606, Slovakia
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Bardejov, 08501, Slovakia
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Bratislava, 81104, Slovakia
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Bratislava, 83101, Slovakia
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Bratislava, 84108, Slovakia
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Bratislava, 85101, Slovakia
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Dolný Kubín, 02601, Slovakia
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Komárno, 94501, Slovakia
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Košice, 040 22, Slovakia
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Košice, 04001, Slovakia
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Košice, 04011, Slovakia
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Košice, 4001, Slovakia
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Levice, 93401, Slovakia
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Levice, 93405, Slovakia
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Lučenec, 984 01, Slovakia
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Lučenec, 98401, Slovakia
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Ľubochňa, 3491, Slovakia
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Moldava nad Bodvou, 045 01, Slovakia
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Nitra, 94901, Slovakia
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Nové Zámky, 94052, Slovakia
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Prešov, 08001, Slovakia
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Rožňava, 048 01, Slovakia
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Svidník, 08901, Slovakia
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Šahy, 93601, Slovakia
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Štúrovo, 943 01, Slovakia
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Žilina, 01001, Slovakia
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Port Elizabeth, Eastern Cape, 6001, South Africa
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Port Elizabeth, Eastern Cape, 6014, South Africa
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Bloemfontein, Free State, 9300, South Africa
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Bloemfontein, Free State, 9301, South Africa
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Centurion, Gauteng, 0157, South Africa
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Johannesburg, Gauteng, 1401, South Africa
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Johannesburg, Gauteng, 2193, South Africa
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Johannesburg, Gauteng, 2196, South Africa
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Kempton Park, Gauteng, 1619, South Africa
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Pretoria, Gauteng, 0002, South Africa
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Pretoria, Gauteng, 0040, South Africa
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Pretoria, Gauteng, 0084, South Africa
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Pretoria, Gauteng, 0087, South Africa
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Pretoria, Gauteng, 0157, South Africa
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Pretoria, Gauteng, 0184, South Africa
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Pretoria, Gauteng, 1692, South Africa
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Alberton, Guateng, 1449, South Africa
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Pretoria, Guateng, 0002, South Africa
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Pretoria, Guateng, 0181, South Africa
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Durban, KwaZulu-Natal, 4001, South Africa
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Durban, KwaZulu-Natal, 4320, South Africa
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Durban, KwaZulu-Natal, 4339, South Africa
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Merebank, KwaZulu-Natal, 4052, South Africa
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Thabazimbi, Limpopo, 0380, South Africa
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Middelburg, Mpumalanga, 1055, South Africa
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Moloto South, Mpumalanga, 1022, South Africa
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Cape Town, Western Cape, 7130, South Africa
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Cape Town, Western Cape, 7405, South Africa
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Cape Town, Western Cape, 7500, South Africa
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Cape Town, Western Cape, 7570, South Africa
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Cape Town, Western Cape, 7580, South Africa
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Cape Town, Western Cape, 7764, South Africa
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Cape Town, Western Cape, 7925, South Africa
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Somerset West, Western Cape, 7130, South Africa
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Worcester, Western Cape, 6850, South Africa
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Santiago de Compostela, La Coruña, 15706, Spain
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A Coruña, 15006, Spain
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Almería, 04120, Spain
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Barcelona, 08003, Spain
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Barcelona, 08023, Spain
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Barcelona, 08025, Spain
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Barcelona, 08034, Spain
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Girona, 17005, Spain
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Madrid, 28007, Spain
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Madrid, 28034, Spain
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Málaga, 29010, Spain
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Seville, 41003, Spain
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Seville, 41010, Spain
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Seville, 41071, Spain
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Adana, 01330, Turkey (Türkiye)
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Ankara, 06500, Turkey (Türkiye)
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Antalya, 07059, Turkey (Türkiye)
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Edirne, 22030, Turkey (Türkiye)
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Eskişehir, 26480, Turkey (Türkiye)
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Istanbul, 34394, Turkey (Türkiye)
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Istanbul, 34846, Turkey (Türkiye)
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Istanbul, 34890, Turkey (Türkiye)
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Izmir, 35100, Turkey (Türkiye)
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Kocaeli, 41380, Turkey (Türkiye)
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Mersin, 33343, Turkey (Türkiye)
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Sivas, 58140, Turkey (Türkiye)
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Brovary, 07400, Ukraine
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Cherkasy, 18009, Ukraine
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Chernivtsi, 58000, Ukraine
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Dnipro, 49005, Ukraine
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Dnipro, 49006, Ukraine
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Dnipro, 49023, Ukraine
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Dnipro, 49038, Ukraine
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Ivano-Frankivsk, 76008, Ukraine
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Ivano-Frankivsk, 76018, Ukraine
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Kharkiv, 61002, Ukraine
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Kharkiv, 61039, Ukraine
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Kharkiv, 61103, Ukraine
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Kharkiv, 61106, Ukraine
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Kharkiv, 61124, Ukraine
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Kharkiv, 61172, Ukraine
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Kharkiv, 61176, Ukraine
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Kyiv, 01023, Ukraine
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Kyiv, 01601, Ukraine
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Kyiv, 02002, Ukraine
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Kyiv, 02091, Ukraine
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Kyiv, 02166, Ukraine
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Kyiv, 02232, Ukraine
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Kyiv, 03037, Ukraine
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Kyiv, 03049, Ukraine
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Kyiv, 03110, Ukraine
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Kyiv, 03115, Ukraine
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Kyiv, 03680, Ukraine
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Kyiv, 04050, Ukraine
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Kyiv, 04053, Ukraine
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Lutsk, 43024, Ukraine
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Lviv, 79011, Ukraine
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Lviv, 79015, Ukraine
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Mykolaiv, 54003, Ukraine
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Odesa, 65025, Ukraine
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Sumy, 40021, Ukraine
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Ternopil, 46010, Ukraine
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Uzhhorod, 88014, Ukraine
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Vinnytsia, 21001, Ukraine
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Vinnytsia, 21005, Ukraine
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Vinnytsia, 21009, Ukraine
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Vinnytsia, 21018, Ukraine
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Vinnytsia, 21029, Ukraine
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Zaporizhzhia, 60106, Ukraine
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Zaporizhzhia, 69001, Ukraine
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Zaporizhzhia, 69005, Ukraine
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Zaporizhzhia, 69063, Ukraine
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Zaporizhzhia, 69104, Ukraine
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Zaporizhzhia, 69600, Ukraine
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Zhytomyr, 10002, Ukraine
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Reading, Berkshire, RG2 0TG, United Kingdom
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Soham, Cambridgeshire, CB7 5JD, United Kingdom
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Fowey, Cornwall, PL23 1DT, United Kingdom
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Hayle, Cornwall, TR27 5DT, United Kingdom
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Torpoint, Cornwall, PL11 2TB, United Kingdom
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Exmouth, Devon, EX8 2JF, United Kingdom
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Plymouth, Devon, PL6 8DH, United Kingdom
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Plymouth, Devon, PL7 2QP, United Kingdom
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Stockton-on-Tees, Durham, TS19 8PE, United Kingdom
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Basildon, Essex, SS16 5NL, United Kingdom
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London, Greater London, EC1M 6BQ, United Kingdom
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Manchester, Greater Manchester, M15 6SX, United Kingdom
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East Kilbride, Lanarkshire, G75 8RG, United Kingdom
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Blackpool, Lancashire, FY4 3AD, United Kingdom
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Chorley, Lancashire, PR7 7NA, United Kingdom
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Edinburgh, Lothian Region, EH16 4SA, United Kingdom
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Liverpool, Merseyside, L22 0LG, United Kingdom
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Airdrie, North Lanarkshire, ML6 0JS, United Kingdom
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Hexham, Northumberland, NE46 1QJ, United Kingdom
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Axbridge, Somerset, BS26 2BJ, United Kingdom
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Bath, Somerset, BA3 2UH, United Kingdom
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Cardiff, South Glamorgan, CF15 9SS, United Kingdom
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Glasgow, Strathclyde, G20 OSP, United Kingdom
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Chertsey, Surrey, KT16 0PZ, United Kingdom
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Dundee, Tayside Region, DD1 9SY, United Kingdom
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Birmingham, West Midlands, B15 2SQ, United Kingdom
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Wakefield, Yorkshire and the Humber, WF1 4DG, United Kingdom
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Wakefield, Yorkshire, WF1 4DG, United Kingdom
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Blackpool, FY3 7EN, United Kingdom
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Chesterfield, S40 4AA, United Kingdom
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Crownhill, PL5 3JB, United Kingdom
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Lincoln, LN2 5QY, United Kingdom
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Oldham, OL1 2JH, United Kingdom
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Royal Leamington Spa, CV32 4RA, United Kingdom
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Sandbach, CW11 1EQ, United Kingdom
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Whitby, YO21 1SD, United Kingdom
Related Publications (13)
Pinkosky SL, Newton RS, Day EA, Ford RJ, Lhotak S, Austin RC, Birch CM, Smith BK, Filippov S, Groot PHE, Steinberg GR, Lalwani ND. Liver-specific ATP-citrate lyase inhibition by bempedoic acid decreases LDL-C and attenuates atherosclerosis. Nat Commun. 2016 Nov 28;7:13457. doi: 10.1038/ncomms13457.
PMID: 27892461BACKGROUNDBilen O, Ballantyne CM. Bempedoic Acid (ETC-1002): an Investigational Inhibitor of ATP Citrate Lyase. Curr Atheroscler Rep. 2016 Oct;18(10):61. doi: 10.1007/s11883-016-0611-4.
PMID: 27663902BACKGROUNDThompson PD, MacDougall DE, Newton RS, Margulies JR, Hanselman JC, Orloff DG, McKenney JM, Ballantyne CM. Treatment with ETC-1002 alone and in combination with ezetimibe lowers LDL cholesterol in hypercholesterolemic patients with or without statin intolerance. J Clin Lipidol. 2016 May-Jun;10(3):556-67. doi: 10.1016/j.jacl.2015.12.025. Epub 2016 Jan 6.
PMID: 27206943BACKGROUNDThompson PD, Rubino J, Janik MJ, MacDougall DE, McBride SJ, Margulies JR, Newton RS. Use of ETC-1002 to treat hypercholesterolemia in patients with statin intolerance. J Clin Lipidol. 2015 May-Jun;9(3):295-304. doi: 10.1016/j.jacl.2015.03.003. Epub 2015 Mar 19.
PMID: 26073387BACKGROUNDNicholls S, Lincoff AM, Bays HE, Cho L, Grobbee DE, Kastelein JJ, Libby P, Moriarty PM, Plutzky J, Ray KK, Thompson PD, Sasiela W, Mason D, McCluskey J, Davey D, Wolski K, Nissen SE. Rationale and design of the CLEAR-outcomes trial: Evaluating the effect of bempedoic acid on cardiovascular events in patients with statin intolerance. Am Heart J. 2021 May;235:104-112. doi: 10.1016/j.ahj.2020.10.060. Epub 2020 Oct 24.
PMID: 33470195BACKGROUNDNissen SE, Lincoff AM, Brennan D, Ray KK, Mason D, Kastelein JJP, Thompson PD, Libby P, Cho L, Plutzky J, Bays HE, Moriarty PM, Menon V, Grobbee DE, Louie MJ, Chen CF, Li N, Bloedon L, Robinson P, Horner M, Sasiela WJ, McCluskey J, Davey D, Fajardo-Campos P, Petrovic P, Fedacko J, Zmuda W, Lukyanov Y, Nicholls SJ; CLEAR Outcomes Investigators. Bempedoic Acid and Cardiovascular Outcomes in Statin-Intolerant Patients. N Engl J Med. 2023 Apr 13;388(15):1353-1364. doi: 10.1056/NEJMoa2215024. Epub 2023 Mar 4.
PMID: 36876740BACKGROUNDNissen SE, Menon V, Nicholls SJ, Brennan D, Laffin L, Ridker P, Ray KK, Mason D, Kastelein JJP, Cho L, Libby P, Li N, Foody J, Louie MJ, Lincoff AM. Bempedoic Acid for Primary Prevention of Cardiovascular Events in Statin-Intolerant Patients. JAMA. 2023 Jul 11;330(2):131-140. doi: 10.1001/jama.2023.9696.
PMID: 37354546BACKGROUNDNicholls SJ, Ray KK, Lincoff AM, Sarnes E, Gillard KK, Bloedon L, Migliaccio-Walle K, Elsea D, Nissen SE. Cost-Effectiveness of Bempedoic Acid in High Cardiovascular Risk Patients with Statin Intolerance: An Analysis of the CLEAR Outcomes Trial. Am J Cardiovasc Drugs. 2025 Aug 20. doi: 10.1007/s40256-025-00753-w. Online ahead of print.
PMID: 40833562DERIVEDLaufs U, Lincoff AM, Nicholls SJ, Li N, Bloedon L, Sasiela WJ, Powell HA, Herout PM, Thompson PD, Nissen SE. Characteristics and outcomes of patients with and without statin-associated muscle symptoms treated with bempedoic acid in the CLEAR Outcomes trial. J Clin Lipidol. 2025 Mar-Apr;19(2):337-347. doi: 10.1016/j.jacl.2024.12.014. Epub 2024 Dec 25.
PMID: 39939212DERIVEDBays HE, Bloedon L, Brennan D, Lei L, Lincoff AM, Nicholls SJ, Plutzky J, Powell HA, Nissen SE. Bempedoic Acid for Prevention of Cardiovascular Events in People With Obesity: A CLEAR Outcomes Subset Analysis. J Am Heart Assoc. 2025 Feb 18;14(4):e037898. doi: 10.1161/JAHA.124.037898. Epub 2025 Feb 8.
PMID: 39921511DERIVEDLincoff AM, Ray KK, Sasiela WJ, Haddad T, Nicholls SJ, Li N, Cho L, Mason D, Libby P, Goodman SG, Nissen SE. Comparative Cardiovascular Benefits of Bempedoic Acid and Statin Drugs. J Am Coll Cardiol. 2024 Jul 9;84(2):152-162. doi: 10.1016/j.jacc.2024.04.048.
PMID: 38960508DERIVEDRay KK, Nicholls SJ, Li N, Louie MJ, Brennan D, Lincoff AM, Nissen SE; CLEAR OUTCOMES Committees and Investigators. Efficacy and safety of bempedoic acid among patients with and without diabetes: prespecified analysis of the CLEAR Outcomes randomised trial. Lancet Diabetes Endocrinol. 2024 Jan;12(1):19-28. doi: 10.1016/S2213-8587(23)00316-9. Epub 2023 Dec 4.
PMID: 38061370DERIVEDRidker PM, Lei L, Louie MJ, Haddad T, Nicholls SJ, Lincoff AM, Libby P, Nissen SE; CLEAR Outcomes Investigators. Inflammation and Cholesterol as Predictors of Cardiovascular Events Among 13 970 Contemporary High-Risk Patients With Statin Intolerance. Circulation. 2024 Jan 2;149(1):28-35. doi: 10.1161/CIRCULATIONAHA.123.066213. Epub 2023 Nov 6.
PMID: 37929602DERIVED
MeSH Terms
Conditions
Interventions
Intervention Hierarchy (Ancestors)
Results Point of Contact
- Title
- Medical Director
- Organization
- Esperion Therapeutics, Inc.
Publication Agreements
- PI is Sponsor Employee
- No
- Restriction Type
- OTHER
- Restrictive Agreement
- Yes
Study Design
- Study Type
- interventional
- Phase
- phase 3
- Allocation
- RANDOMIZED
- Masking
- TRIPLE
- Who Masked
- PARTICIPANT, INVESTIGATOR, OUTCOMES ASSESSOR
- Purpose
- TREATMENT
- Intervention Model
- PARALLEL
- Sponsor Type
- INDUSTRY
- Responsible Party
- SPONSOR
Study Record Dates
First Submitted
December 9, 2016
First Posted
December 15, 2016
Study Start
December 22, 2016
Primary Completion
November 7, 2022
Study Completion
November 7, 2022
Last Updated
January 3, 2024
Results First Posted
January 3, 2024
Record last verified: 2023-12
Data Sharing
- IPD Sharing
- Will not share