The Effect of Oral Zinc Supplementation on Thiol Oxido-reductive Index

NCT02985905 | Completed Phase 2

• 1 other identifier: Babil-4
• Study Type: interventional
• Target: 120
• Locations: 1 country
• Sites: 1

Brief Summary

Although several studies have considered the relationship between infertility and semen thiol compounds levels, no study on the effects of asthenospermia treatments such as oral zinc supplementation on thiol related enzymes activity which are important in fertility of the individual has been reported.

Conditions

Asthenozoospermia

Keywords

Zinc supplementation; Thiol; Glutathione peroxidase; Sulfhydryl oxidase

Outcome Measures

Primary Outcomes (1)

• Thiol oxido-reductive index levels in spermatozoa and seminal plasma. The investigators evaluated the effects of zinc sulfate (220 mg/d) supplementation on Thiol oxido-reductive index levels.

  up to three months.

Secondary Outcomes (2)

• Glutathione peroxidase activity levels in spermatozoa and seminal plasma. The investigators evaluated the effects of zinc sulfate (220 mg/d) supplementation on Glutathione peroxidase activity levels.

  up to three months.

• Sulfhydryl oxidase activity levels in spermatozoa and seminal plasma. The investigators evaluated the effects of zinc sulfate (220 mg/d) supplementation on Sulfhydryl oxidase activity levels.

  up to three months.

Study Arms (2)

Zinc sulfate

EXPERIMENTAL

60 subfertile (age 32.5±3.23 year) men with asthenozoospermia was treated with zinc sulfate,every participant took two capsules of zinc sulfate per day for three months (each one 220 mg).

Dietary Supplement: zinc sulfate

Healthy control

NO INTERVENTION

60 fertile (age 31.6±3.3 year) men, no treatment

Interventions

zinc sulfate DIETARY_SUPPLEMENT

The subfertile group treated with zinc sulfate, every participant took two capsules of zinc sulfate per day for three months (each one 220 mg).

Zinc sulfate

Eligibility Criteria

• Age: 26 Years - 36 Years
• Sex: male
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• The presence of asthenozoospermia in the semen sample.

You may not qualify if:

• The absence of endocrinopathy, varicocele, and female factor infertility. Smokers and alcoholic men were excluded from the study because of their recognized high seminal ROS levels and decreased antioxidant levels.

Sponsors & Collaborators

• mahmoud hussein hadwan: lead
• Ministry of Health, Iraq: collaborator

Study Sites (1)

Mahmoud Hadwan

Hillah, Babylon, 51002, Iraq

Location

Related Publications (1)

• Alsalman ARS, Almashhedy LA, Hadwan MH. Effect of Oral Zinc Supplementation on the Thiol Oxido-Reductive Index and Thiol-Related Enzymes in Seminal Plasma and Spermatozoa of Iraqi Asthenospermic Patients. Biol Trace Elem Res. 2018 Aug;184(2):340-349. doi: 10.1007/s12011-017-1215-8. Epub 2017 Dec 8.

  PMID: 29222649 DERIVED

MeSH Terms

Conditions

Asthenozoospermia

Interventions

Zinc Sulfate

Condition Hierarchy (Ancestors)

Infertility, Male; Genital Diseases, Male; Genital Diseases; Urogenital Diseases; Infertility; Male Urogenital Diseases

Intervention Hierarchy (Ancestors)

Sulfates; Sulfuric Acids; Sulfur Acids; Sulfur Compounds; Inorganic Chemicals; Zinc Compounds

Study Officials

• Mahmoud Hadwan, PhD

  Babylon University

  PRINCIPAL INVESTIGATOR

• L Almashhedy, PhD

  Babylon University

  STUDY DIRECTOR

• Alsalman Abdulrrazaq, PhD

  Babylon University

  STUDY CHAIR

Study Design

• Study Type: interventional
• Phase: phase 2
• Allocation: NON RANDOMIZED
• Masking: NONE
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR INVESTIGATOR
• PI Title: Principal Investigator

Study Record Dates

• First Submitted: December 2, 2016
• First Posted: December 7, 2016
• Study Start: July 1, 2011
• Primary Completion: July 1, 2012
• Study Completion: July 1, 2012
• Last Updated: December 7, 2016

Record last verified: 2016-12

Data Sharing

• IPD Sharing: Will share

Locations

IR (1)