Study the Effect of Oral Zinc Supplementation on High Molecular Weight Zinc Binding Protein in Semen
supplement
1 other identifier
observational
37
1 country
2
Brief Summary
There are several causes leading to male infertility, like oxidative stress, and nutritional deficiency of trace elements like zinc. Zinc in human seminal plasma was divided into three types of ligands which are high (HMW), intermediate (IMW), and low molecular weight ligands (LMW). The present study was conducted to study the effect of Zn supplementation on the quantitative and qualitative characteristics of semen along with Zinc Binding Protein levels in semen of patients with asthenozoospmia.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P25-P50 for all trials
Started Jul 2011
Shorter than P25 for all trials
2 active sites
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
Click on a node to explore related trials.
Study Timeline
Key milestones and dates
Study Start
First participant enrolled
July 1, 2011
CompletedPrimary Completion
Last participant's last visit for primary outcome
April 1, 2012
CompletedStudy Completion
Last participant's last visit for all outcomes
April 1, 2012
CompletedFirst Submitted
Initial submission to the registry
June 1, 2012
CompletedFirst Posted
Study publicly available on registry
June 5, 2012
CompletedJune 6, 2012
June 1, 2012
9 months
June 1, 2012
June 5, 2012
Conditions
Keywords
Outcome Measures
Primary Outcomes (1)
high molecular weight zinc binding protein
elevated levels of high molecular weight zinc binding protein to normal value
at the end of three months
Secondary Outcomes (1)
qualitative semen parameters
at the end of three months
Study Arms (1)
Single group
Single group: all participants receive same intervention throughout study (Non-randomised)
Interventions
every participant took two capsules of zinc sulfate per day for three months (each one 220mg)
Eligibility Criteria
This study includes 37 subfertile male partners from couples who had consulted the infertility clinic of the Babil hospital of maternity (Hilla city/ IRAQ).
You may not qualify if:
- the absence of endocrinopathy,
- varicocele, and
- female factor infertility. Smokers and alcoholic men were excluded from the study because of their recognized high seminal ROS levels and decreased antioxidant levels.
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (2)
Babylon university/ college of science
Hillah, Hilla, IQ, Iraq
Babylon University
Hillah, Hilla, IQ, Iraq
Related Publications (1)
Hadwan MH, Almashhedy LA, Alsalman AR. Oral zinc supplementation restores high molecular weight seminal zinc binding protein to normal value in Iraqi infertile men. BMC Urol. 2012 Nov 13;12:32. doi: 10.1186/1471-2490-12-32.
PMID: 23145537DERIVED
MeSH Terms
Conditions
Interventions
Condition Hierarchy (Ancestors)
Intervention Hierarchy (Ancestors)
Study Officials
- PRINCIPAL INVESTIGATOR
mahmoud H. hadwan, Dr.
babylon university / Iraq
Study Design
- Study Type
- observational
- Observational Model
- CASE CONTROL
- Time Perspective
- RETROSPECTIVE
- Sponsor Type
- OTHER
- Responsible Party
- SPONSOR INVESTIGATOR
- PI Title
- Researcher
Study Record Dates
First Submitted
June 1, 2012
First Posted
June 5, 2012
Study Start
July 1, 2011
Primary Completion
April 1, 2012
Study Completion
April 1, 2012
Last Updated
June 6, 2012
Record last verified: 2012-06