Chronic Mycoprotein Consumption and Nucleotide Content in Metabolic Health

NCT02984358 | Completed

• 1 other identifier: 660065613
• Study Type: interventional
• Target: 30
• Locations: 0 countries
• Sites: N/A

Brief Summary

Compare chronic (one week) of a 'normal' meat diet with one week of mycoprotein consumption, with or without a reduced nucleotide content, on markers of metabolic health, such as uric acid concentrations, blood glucose control and blood lipid profiles.

Conditions

Healthy

Outcome Measures

Primary Outcomes (1)

• Serum uric acid concentrations

  Measured at baseline; days 2, 4 and 6 of the intervention; and after the 1 week intervention (day 8)

Secondary Outcomes (4)

• Glycaemia and serum insulin - insulin sensitivity (oral glucose tolerance test)

  Measured at baseline and after 1 week intervention (day 8)

• IL-6

  Measured at baseline and after 1 week intervention (day 8)

• 24 h blood glucose homeostasis - measured using a Dexcom CGMS

  Measured 5 days at baseline (habitual data) and 5 days during the intervention (days 3 - 7)

• Metabolomics (using Nuclear Magnetic Resonance - NMR)

  Measured at baseline; days 2, 4 and 6 of the intervention; and after the 1 week intervention (day 8)

Study Arms (3)

Animal protein based diet

PLACEBO COMPARATOR

Seven day fully controlled normocaloric diet (1.2 g/ kg body weight of protein per day), with the main protein source at the two main meals (lunch and dinner) being provided by animal products (meat and fish).

Other: Animal protein based diet

Low-nucleotide mycoprotein based diet

ACTIVE COMPARATOR

Seven day fully controlled normocaloric diet (1.2 g/ kg body weight of protein per day), with the main protein source at the two main meals (lunch and dinner) being provided by nucleotide-depleted mycoprotein products (commercial Quorn products).

Other: Low-nucleotide mycoprotein based diet

High-nucleotide mycoprotein based diet

ACTIVE COMPARATOR

Seven day fully controlled normocaloric diet (1.2 g/ kg body weight of protein per day), with the main protein source at the two main meals (lunch and dinner) being provided by nucleotide-rich mycoprotein products.

Other: High-nucleotide mycoprotein based diet

Interventions

Animal protein based diet OTHER

Animal protein based diet

Low-nucleotide mycoprotein based diet OTHER

Low-nucleotide mycoprotein based diet

High-nucleotide mycoprotein based diet OTHER

High-nucleotide mycoprotein based diet

Eligibility Criteria

• Age: 18 Years - 40 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• BMI between 18 and 30

You may not qualify if:

• On medication (except contraception)
• Smokers
• Diagnosed with any metabolic or cardiovascular conditions
• BMI \< 18 or \> 30
• Dietary restrictions (vegetarians/vegans, etc.)

Sponsors & Collaborators

• University of Exeter: lead

Related Publications (1)

• Coelho MOC, Monteyne AJ, Kamalanathan ID, Najdanovic-Visak V, Finnigan TJA, Stephens FB, Wall BT. High dietary nucleotide consumption for one week increases circulating uric acid concentrations but does not compromise metabolic health: A randomised controlled trial. Clin Nutr ESPEN. 2022 Jun;49:40-52. doi: 10.1016/j.clnesp.2022.04.022. Epub 2022 Apr 25.

  PMID: 35623844 DERIVED

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: TRIPLE
• Who Masked: PARTICIPANT, INVESTIGATOR, OUTCOMES ASSESSOR
• Purpose: BASIC SCIENCE
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: December 2, 2016
• First Posted: December 6, 2016
• Study Start: January 1, 2017
• Primary Completion: December 1, 2017
• Study Completion: December 1, 2017
• Last Updated: June 15, 2018

Record last verified: 2018-06

Data Sharing

• IPD Sharing: Will not share