Brief Summary

This research trial collects biological samples and clinical information to create a repository of data from patients with cancer or a predisposition for cancer. Combining genetic information from biological samples and clinical data may lead to more knowledge about why certain cancers respond to treatment and help create more personalized medicine.

Trial Health

On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment

10,000

participants targeted

Target at P75+ for all trials

Timeline

134mo left

Started May 2016

Longer than P75 for all trials

Geographic Reach

1 country

1 active site

Status

recruiting

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

21 years study duration

Study Progress48%

May 2016May 2037

Study Start

First participant enrolled

May 2, 2016

Completed

3 months until next milestone

First Submitted

Initial submission to the registry

July 29, 2016

Completed

4 months until next milestone

First Posted

Study publicly available on registry

November 21, 2016

Completed

19.5 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

May 2, 2036

Expected

1 year until next milestone

Study Completion

Last participant's last visit for all outcomes

May 2, 2037

Last Updated

April 29, 2026

Status Verified

April 1, 2026

Enrollment Period

20 years

First QC Date

July 29, 2016

Last Update Submit

April 24, 2026

Conditions

Cancer Risk Malignant Neoplasm

Outcome Measures

Primary Outcomes (1)

Number of biospecimen collected for a centralized repository that is linked to clinical data
Establish and maintain a unique repository of blood, tissue, other biological samples and their associated data (survey data, medical records data, cancer registry data, and other related data) collected from thousands of patients 18 years of age or older who have cancer or are at risk of developing cancer.
Up to 21 years

Study Arms (1)

Ancillary-Correlative (biospecimen collection)

Patients undergo collection of blood during a regular care visit or not up to 4 times a year. Extra tissue is collected after removal during standard of care surgery and patients may undergo additional tumor sampling (needle passes) at the time of planned diagnostic biopsies. During bone marrow biopsy, the doctor may reposition the needle up to 3 times, and bone marrow for research will not be collected more than 4 times per year. Patients may undergo additional collection of other biological samples such as saliva, sputum, urine, feces, hair, and surface skin swabs for analysis. Patients also receive surveys or questionnaires to collect demographics, medical, family, and nutritional history, cancer predisposing risk factors, quality of life data, and quality of care data.

Procedure: Biospecimen CollectionProcedure: Evaluation of Cancer Risk FactorsOther: Medical Chart ReviewOther: Quality-of-Life AssessmentOther: Questionnaire Administration