Hyperemesis Gravidarum and 75 Gram Oral Glucose Tolerance Test

NCT02963753 | Completed

• 1 other identifier: 2017/173
• Study Type: observational
• Target: 560
• Locations: 0 countries
• Sites: N/A

Brief Summary

Hyperemesis gravidarum (HEG) is not only nausea and vomiting of pregnancy, but it is also a clinical syndrome including endocrine and metabolic complications. Recently, some investigators have been begun performing researches related to the development of gestational diabetes mellitus (GDM) in pregnant women with HEG because they think about those metabolic and endocrine complications of HEG.In the literature there are few studies assessing how HEG has effects on GDM or 75 gram oral glucose tolerance test (OGTT). So the investigators aim to evaluate the effects of HEG on 75 gram OGTT.

Conditions

Hyperemesis; Gravidarum, With Dehydration; Gestational Diabetes

Keywords

Hyperemesis gravidarum; gestational diabetes mellitus; oral glucose tolerance test

Outcome Measures

Primary Outcomes (1)

• To determine serum glucose levels in both groups during 75 gram oral glucose tolerance test screening

  3 months

Study Arms (2)

hyperemesis gravidarum group

The study group consisted of women hospitalized for hyperemesis during first trimester of their pregnancy

the control group

whereas the control group included all other women who delivered in the same period.

Eligibility Criteria

• Age: 18 Years - 35 Years
• Sex: female
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)
• Sampling Method: Non-Probability Sample

Study Population

This study was carried out with two groups. The study group consisted of women hospitalized for HEG during first trimester of their pregnancy, whereas the control group included all other women who delivered in the same period. When the pregnant women had those symptoms such as the presence of intractable vomiting during pregnancy associated with dehydration, electrolyte,and/or metabolic disturbances, as well as a weight loss 5% or more, they were diagnosed as HEG.

You may qualify if:

• between 18 and 35 years-old singleton pregnancies and performed 75 gram OGTT

You may not qualify if:

• Other causes lead to nausea and vomiting in pregnancy such as gastroenteritis, gastroparesis, hepatitis, intestinal obstruction, peptic ulcer, appendicitis, pyelonephritis, urolithiasis, ovarian torsion, diabetes mellitus, hyperthyroidism, hyperparathyroidism, migraine.
• And also patients who have risks for GDM such as body mass index \> 30, history of GDM in previous pregnancy and diabetes in the family were excluded.

Sponsors & Collaborators

• Kayseri Education and Research Hospital: lead

MeSH Terms

Conditions

Hyperemesis Gravidarum; Diabetes, Gestational

Condition Hierarchy (Ancestors)

Morning Sickness; Pregnancy Complications; Female Urogenital Diseases and Pregnancy Complications; Urogenital Diseases; Vomiting; Signs and Symptoms, Digestive; Signs and Symptoms; Pathological Conditions, Signs and Symptoms; Diabetes Mellitus; Glucose Metabolism Disorders; Metabolic Diseases; Nutritional and Metabolic Diseases; Endocrine System Diseases

Study Officials

• YUSUF MADENDAG

  Kayseri Education and Research Hospital

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER GOV
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Principal Investigator

Study Record Dates

• First Submitted: November 10, 2016
• First Posted: November 15, 2016
• Study Start: January 1, 2016
• Primary Completion: November 1, 2016
• Study Completion: November 1, 2016
• Last Updated: April 13, 2017

Record last verified: 2017-04