NCT02958865

Brief Summary

The purpose of this study is to determine whether PF-06651600 and PF-06700841 are effective in treatment of moderate to severe ulcerative colitis.

Trial Health

98
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Strong global presence with extensive site network
Enrollment
319

participants targeted

Target at P75+ for phase_2

Timeline
Completed

Started Feb 2017

Typical duration for phase_2

Geographic Reach
19 countries

189 active sites

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

First Submitted

Initial submission to the registry

November 4, 2016

Completed
4 days until next milestone

First Posted

Study publicly available on registry

November 8, 2016

Completed
3 months until next milestone

Study Start

First participant enrolled

February 3, 2017

Completed
4.3 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

May 10, 2021

Completed
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

May 10, 2021

Completed
1.2 years until next milestone

Results Posted

Study results publicly available

July 21, 2022

Completed
Last Updated

July 21, 2022

Status Verified

June 1, 2022

Enrollment Period

4.3 years

First QC Date

November 4, 2016

Results QC Date

May 9, 2022

Last Update Submit

June 27, 2022

Conditions

Keywords

Mayo score

Outcome Measures

Primary Outcomes (1)

  • Total Mayo Score at Week 8 (Induction Period)

    The Mayo score is a tool designed to measure disease activity for ulcerative colitis. The Mayo scoring system ranges from 0 to 12 points and consists of 4 subscores, which are stool frequency, rectal bleeding, findings on endoscopy and physician's global assessment. Each subscore graded 0 to 3 with the higher score indicates more severe disease activity and lower score denotes improvement of disease activity as measured by the total Mayo score.

    Week 8

Secondary Outcomes (34)

  • Number of Participants With AEs, SAEs and Discontinuation Due to AEs (Chronic Period)

    From Week 8 up to Week 32

  • Number of Participants With Laboratory Test Abnormalities (Chronic Period)

    From Week 8 to Week 32

  • Number of Participants With Laboratory Test Abnormalities-hematology (Chronic Period)

    From Week 8 to Week 32

  • Number of Participants With Abnormal Vital Signs Data (Chronic Period)

    From Week 8 to Week 32

  • Number of Participants With Abnormal ECG Findings (Chronic Period)

    Week 8 to Week 32

  • +29 more secondary outcomes

Other Outcomes (1)

  • Change From Baseline in Total Mayo Score at Week 32 (Chronic Period)

    Week 32

Study Arms (10)

PF-06651600 Drug Dose Level 1

EXPERIMENTAL

Delivered orally for 8 weeks

Drug: PF-06651600 or Placebo

PF-06651600 Drug Dose Level 2

EXPERIMENTAL

Delivered orally for 8 weeks

Drug: PF-06651600 or Placebo

PF-06651600 Drug Dose Level 3

EXPERIMENTAL

Delivered orally for 8 weeks.

Drug: PF-06651600 or Placebo

PF-06651600 Placebo

PLACEBO COMPARATOR

Delivered orally for 8 weeks.

Drug: PF-06651600 or Placebo

PF-06700841 Drug Dose Level 1

EXPERIMENTAL

Delivered orally for 8 weeks

Drug: PF-06700841 or Placebo

PF-06700841 Drug Dose Level 2

EXPERIMENTAL

Delivered orally for 8 weeks.

Drug: PF-06700841 or Placebo

PF-06700841 Drug Dose Level 3

EXPERIMENTAL

Delivered orally for 8 weeks.

Drug: PF-06700841 or Placebo

PF-06700841 Placebo

PLACEBO COMPARATOR

Delivered orally for 8 weeks.

Drug: PF-06700841 or Placebo

PF-06651600 Drug Dose Level 4

EXPERIMENTAL

Delivered orally for 24 weeks.

Drug: PF-06651600

PF-06700841 Drug Dose Level 4

EXPERIMENTAL

Delivered orally for 24 weeks.

Drug: PF-06700841

Interventions

Delivered orally for 8 weeks.

PF-06651600 Drug Dose Level 1PF-06651600 Drug Dose Level 2PF-06651600 Drug Dose Level 3PF-06651600 Placebo

Delivered orally for 8 weeks.

PF-06700841 Drug Dose Level 1PF-06700841 Drug Dose Level 2PF-06700841 Drug Dose Level 3PF-06700841 Placebo

Delivered orally for 24 weeks.

PF-06700841 Drug Dose Level 4

Delivered orally for 24 weeks.

PF-06651600 Drug Dose Level 4

Eligibility Criteria

Age18 Years - 75 Years
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64), Older Adult (65+)

You may qualify if:

  • Diagnosis of ulcerative colitis for greater than/equal to 3 months.
  • Moderate to severe active ulcerative colitis
  • Inadequate response to, loss of response to, or intolerance to at least one conventional therapy for UC.

You may not qualify if:

  • Pregnant or breastfeeding
  • Clinical findings suggestive of Crohn's Disease
  • History of bowel surgery within 6 months

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (189)

Dothan Surgery Center

Dothan, Alabama, 36301, United States

Location

Gut P.C., dba Digestive Health Specialists of the Southeast

Dothan, Alabama, 36305, United States

Location

Long Beach Clinical Trials Services Inc.

Long Beach, California, 90806, United States

Location

Southern California Research Institute Medical Group/West Gastroenterology Medical Group/Airport En-

Los Angeles, California, 90045, United States

Location

Clinical Application Laboratories, INC.

San Diego, California, 92103, United States

Location

San Diego Endoscopy Center

San Diego, California, 92103, United States

Location

Medical Associates Research Group

San Diego, California, 92123, United States

Location

Front Range Endoscopy Center

Colorado Springs, Colorado, 80903, United States

Location

Peak Gastroenterology Associates

Colorado Springs, Colorado, 80907, United States

Location

Bristol Hospital

Bristol, Connecticut, 06010, United States

Location

Connecticut Clinical Research Institute

Bristol, Connecticut, 06010, United States

Location

Central Connecticut Endoscopy Center

Plainville, Connecticut, 06062, United States

Location

West Coast Endoscopy Center

Clearwater, Florida, 33756, United States

Location

University of Miami Hospital and Clinics

Miami, Florida, 33136, United States

Location

University of Miami Hospital

Miami, Florida, 33136, United States

Location

Millenia Surgery Center

Orlando, Florida, 32811, United States

Location

HMD Research LLC

Orlando, Florida, 32819, United States

Location

Orlando Gastroenterology, PA

Orlando, Florida, 32835, United States

Location

Southwest Gastroenterology

Oak Lawn, Illinois, 60453, United States

Location

Chevy Chase Endoscopy Center

Chevy Chase, Maryland, 20815, United States

Location

Feldman ENT

Chevy Chase, Maryland, 20815, United States

Location

MGG Group Co. Inc., Chevy Chase Clinical Research

Chevy Chase, Maryland, 20815, United States

Location

Cascades Endoscopy Center

Columbia, Maryland, 21045, United States

Location

Gastro Center of Maryland

Columbia, Maryland, 21045, United States

Location

Brigham and Women's Hospital

Boston, Massachusetts, 02115, United States

Location

Brigham and Women's Hospital

Chestnut Hill, Massachusetts, 02467, United States

Location

Concorde medical Group, PLLC

New York, New York, 10016, United States

Location

Kips Bay Endoscopy Center

New York, New York, 10016, United States

Location

New York University Langone Medical Center

New York, New York, 10016, United States

Location

NYU Clinical Cancer Center

New York, New York, 10016, United States

Location

NYU Langone Medical Center

New York, New York, 10016, United States

Location

NYU Medical Science Building

New York, New York, 10016, United States

Location

Weill Cornell Medical College - New York Presbyterian Hospital

New York, New York, 10021, United States

Location

Weill Cornell Medical College

New York, New York, 10021, United States

Location

New York Presbyterian Hospital-Weill Cornell Medical College

New York, New York, 10065, United States

Location

Weill Cornell Medical College-New York Presbyterian Hospital

New York, New York, 10065, United States

Location

Weill Cornell Medical College

New York, New York, 10065, United States

Location

University of Rochester Medical Center

Rochester, New York, 14642, United States

Location

UNC Hospitals

Chapel Hill, North Carolina, 27514, United States

Location

UNC Hospitals Endoscopy Center at Meadowmont

Chapel Hill, North Carolina, 27517, United States

Location

University of North Carolina at Chapel Hill

Chapel Hill, North Carolina, 27599-7064, United States

Location

University of North Carolina at Chapel Hill

Chapel Hill, North Carolina, 27599-7080, United States

Location

Digestive Disease Specialists, Inc.

Oklahoma City, Oklahoma, 73112, United States

Location

Gastro One

Germantown, Tennessee, 38138, United States

Location

Parkland Health and Hospital System

Dallas, Texas, 75235, United States

Location

UT Southwestern Medical Center - CRU Aston

Dallas, Texas, 75390-8887, United States

Location

UT Southwestern Medical Center-Clements University Hospital

Dallas, Texas, 75390, United States

Location

UT Southwestern Medical Center

Dallas, Texas, 75390, United States

Location

Baylor College of Medicine- Baylor Medical Center

Houston, Texas, 77030, United States

Location

Baylor St. Luke's Medical Center Endoscopy-McNair Campus

Houston, Texas, 77030, United States

Location

Gulf Coast Research Group

Houston, Texas, 77098, United States

Location

Lonestar Endoscopy, LLP

Keller, Texas, 76248, United States

Location

Sagact, Pllc.

San Antonio, Texas, 78229, United States

Location

Sagact, Pllc

San Antonio, Texas, 78229, United States

Location

Lonestar Endoscopy, LLP

Southlake, Texas, 76092, United States

Location

Texas Digestive Disease Consultants

Southlake, Texas, 76092, United States

Location

Verity Research

Fairfax, Virginia, 22031, United States

Location

Blue Ridge Medical Research

Lynchburg, Virginia, 24502, United States

Location

McGuire DVAMC

Richmond, Virginia, 23249, United States

Location

University of Washington

Seattle, Washington, 98195, United States

Location

AKH Wien Universitaetsklinik fuer Innere Medizin III

Vienna, 1090, Austria

Location

"Medical Center-1- Sevlievo" EOOD

Sevlievo, Gabrovo, 5400, Bulgaria

Location

"MHAT-Blagoevgrad" AD

Blagoevgrad, 2700, Bulgaria

Location

MHAT Dobrich AD

Dobrich, 9300, Bulgaria

Location

MC Hipocrat-2000 OOD

Haskovo, 6300, Bulgaria

Location

MHAT Prof. Dr. Paraskev Stoyanov AD

Lovech, 5500, Bulgaria

Location

Medical Center Vitadar Consult OOD

Rousse, 7000, Bulgaria

Location

SHATPPD dr. Dimitar Gramatikov - Ruse EOOD

Rousse, 7002, Bulgaria

Location

"MC Asklepion - researches in human medicine"" EOOD

Sofia, 1303, Bulgaria

Location

"Acibadem City Clinic UMHAT" EOOD

Sofia, 1784, Bulgaria

Location

Hepato-Gastroenterologie HK, s.r.o.

Hradec Králové, 50012, Czechia

Location

Fakultni nemocnice v Motole

Prague, 150 06, Czechia

Location

Nemocnice Slany, p.o.

Slaný, 274 01, Czechia

Location

Nemocnice Strakonice, a.s., interni oddeleni

Strakonice, 386 01, Czechia

Location

Nordsjaellands Hospital Frederikssund

Frederikssund, 3600, Denmark

Location

Nordsjaellands Hospital Hilleroed

Hilleroed, 3400, Denmark

Location

Amager og Hvidovre Hospital

Hvidovre, 2650, Denmark

Location

Odense Universitetshospital

Odense, 5000, Denmark

Location

Research institute of Clinical Medicine

Tbilisi, 0112, Georgia

Location

The First University Clinic of TSMU

Tbilisi, 0141, Georgia

Location

Paian MED Research GmbH

Berlin, 10318, Germany

Location

Gastrostudien GbR

Berlin, 10825, Germany

Location

Krankenhaus Waldfriede e.V.

Berlin, 14163, Germany

Location

MVZ Dachau - Patientenzentrum

Dachau, 85221, Germany

Location

MVZ Dachau

Dachau, 85221, Germany

Location

Asklepios Westklinikum Hamburg

Hamburg, 22559, Germany

Location

Universitaetsklinikum Schleswig-Holstein

Kiel, 24105, Germany

Location

Eugastro GmbH

Leipzig, 04103, Germany

Location

Bekes Megyei Kozponti Korhaz, Rethy Pal Tagkorhaz

Békéscsaba, 5600, Hungary

Location

Semmelweis Egyetem, II. Belgyogyaszati Klinika

Budapest, 1088, Hungary

Location

Szent Janos Korhaz es Eszak-budai Egyesitett Korhazak I. Belgyogyaszati Gasztroenterologiai Osztaly

Budapest, 1125, Hungary

Location

Pannonia Maganorvosi Centrum

Budapest, 1136, Hungary

Location

Tolna Megyei Balassa Janos Korhaz

Szekszárd, 7100, Hungary

Location

Javorszky Odon Korhaz, Gasztroenterologia

Vác, 2600, Hungary

Location

Clalit Health Services

Bat Yam, 5962025, Israel

Location

Shaare Zedek Medical Center

Jerusalem, 9103102, Israel

Location

Diabetes and Endocrinology Unit

Tel Aviv, 6203854, Israel

Location

Migdal Hamea Clinic

Tel Aviv, 6203854, Israel

Location

IRCCS Saverio De Bellis

Castellana Grotte, BARI, 70013, Italy

Location

AOU Sant'Orsola-Malpighi

Bologna, BO, 40138, Italy

Location

A.O.U. Policlinico G. Martino

Messina, ME, 98125, Italy

Location

Istituto Clinico Humanitas

Rozzano, Milan (MI), 20089, Italy

Location

ASST Rhodense - Ospedale di Circolo di Rho

Rho, Milano (MI), 20017, Italy

Location

Azienda Ospedaliero Universitaria Pisana

Pisa, PI, 56124, Italy

Location

Policlinico Universitario Campus Biomedico

Roma, RM, 00128, Italy

Location

AOU Policlinico di Modena

Modena, 41124, Italy

Location

Azienda Ospedaliera di Padova

Padua, 35128, Italy

Location

Azienda Sanitaria Universitaria Integrata Udine

Udine, 33100, Italy

Location

SPZOZ Wojewodzki Szpital Zespolony im. Jedrzeja Sniadeckiego w Bialymstoku

Bialystok, 15-950, Poland

Location

ETG Kielce

Kielce, 25-355, Poland

Location

Gastromed Sp. z o.o.

Lublin, 20-582, Poland

Location

Ai Centrum Medyczne Sp. Z O.O. Sp.K.

Poznan, 61-113, Poland

Location

KO-MED Centra Kliniczne Pulawy

Puławy, 24-100, Poland

Location

ENDOSKOPIA Sp. z o. o.

Sopot, 81-756, Poland

Location

H-T. Centrum Medyczne

Tychy, 43-100, Poland

Location

Centrum Zdrowia MDM

Warsaw, 00-635, Poland

Location

WIP Warsaw IBD Point Profesor Kierkus

Warsaw, 00-728, Poland

Location

Melita Medical Sp z o.o.

Wroclaw, 50-449, Poland

Location

Centrum Badan Klinicznych, Osrodek Badan Wczesnej Fazy

Wroclaw, 51-162, Poland

Location

Lexmedica

Wroclaw, 53-114, Poland

Location

EMC Instytut Medyczny S.A., Szpital Specjalistyczny EuroMediCare z Przychodnia

Wroclaw, 54-144, Poland

Location

Centrum Diagnostyczno-Lecznicze Barska Sp. z o. o.

Włocławek, 87-800, Poland

Location

Spitalul Universitar de Urgenta Militar Central "Dr. Carol Davila" Bucuresti

Bucharest, Sector 1,, 010825, Romania

Location

S.C. Cabinet Particular Policlinic Algomed SRL

Timișoara, Timiș County, 300002, Romania

Location

Spitalul Clinic Colentina, Sectia de Gastroenterologie

Bucharest, 020125, Romania

Location

LLC "Olla-Med"

Moscow, 105554, Russia

Location

FSAEI HE I.M.Sechenov 1st Moscow State Medical University of the MoH of the RF (Sechenov University)

Moscow, 119435, Russia

Location

Limited Liability Company "Medicinsky Center SibNovoMed"

Novosibirsk, 630005, Russia

Location

LLC Novosibirskiy Gastrocentr

Novosibirsk, 630007, Russia

Location

Novosibirskiy Gastrocenter

Novosibirsk, 630007, Russia

Location

Federal State Budgetary Scientific Institution

Novosibirsk, 630117, Russia

Location

FGBOU VO OmGMU Minzdrava Rossii

Omsk, 644050, Russia

Location

FSBEI HE "Rostov State Medical University" of the Ministry of Healthcare of the Russian Federation

Rostov-on-Don, 344022, Russia

Location

State Budgetary Institution of Ryazan Region "Regional Clinical Hospital"

Ryazan, 390039, Russia

Location

RIAT Limited Liability Company (RIAT LLC)

Saint Petersburg, 195220, Russia

Location

Saint-Petersburg State Budgetary Healthcare Institution

Saint Petersburg, 195257, Russia

Location

Medical University REAVIZ

Samara, 443011, Russia

Location

Private Healthcare Institution "Clinical Hospital "RZhD-Medicina" City Samara"

Samara, 443029, Russia

Location

LLC Medical Company Hepatolog

Samara, 443063, Russia

Location

LLC Medical Company Hepatolog

Samara, 443076, Russia

Location

State Budgetary Institution of Healthcare Yaroslavl Regional Clinical Hospital

Yaroslavl, 150062, Russia

Location

Clinical Hospital Centre Zvezdara Clinic for Internal Diseases

Belgrade, 11000, Serbia

Location

Clinical Hospital Centre Bezanijska Kosa Clinic for Internal Medicine

Belgrade, 11080, Serbia

Location

Clinical Centre of Kragujevac

Kragujevac, 34000, Serbia

Location

Clinical Centre of Nis, Clinic for Gastroenterology and Hepatology

Niš, 18000, Serbia

Location

General Hospital Subotica

Subotica, 24000, Serbia

Location

Clinical Hospital Center Zemun

Zemun, Belgrade, 11080, Serbia

Location

General Hospital "Djordje Joanovic"

Zrenjanin, 23000, Serbia

Location

Abawi spol. s r.o

Bratislava, 82107, Slovakia

Location

KM Management spol. s.r.o.

Nitra, 949 01, Slovakia

Location

MUDr. Frantisek Horvath Gastroenterologia

Šahy, 936 01, Slovakia

Location

ENDOMED, s.r.o.

Vranov nad Topľou, 093 01, Slovakia

Location

Kyungpook National University Hospital

Daegu, 41944, South Korea

Location

Keimyung University Dongsan Hospital

Daegu, 42601, South Korea

Location

Severance Hospital, Yonsei University Health System

Seoul, 03722, South Korea

Location

The Catholic University of Korea, Seoul St. Mary's Hospital

Seoul, 06591, South Korea

Location

Hospital Universitari de Bellvitge

L'Hospitalet de Llobregat, Barcelona, 08907, Spain

Location

Hospital Universitario Marques de Valdecilla

Santander, Cantabria, 39008, Spain

Location

Hospital Universitario Fundacion Alcorcon

Alcorcón, Madrid, 28922, Spain

Location

Hospital Universitario Puerta de Hierro de Majadahonda

Majadahonda, Madrid, 28222, Spain

Location

Hospital Clinic de Barcelona

Barcelona, 08036, Spain

Location

Hospital Universitario Virgen del Rocio

Seville, 41013, Spain

Location

Hospital Universitari i Politecnic La Fe

Valencia, 46026, Spain

Location

Ankara Universitesi Tip Fakultesi, Ibn-i Sina Hastanesi, Ic Hastaliklari Anabilim Dali,

Ankara, 06100, Turkey (Türkiye)

Location

Ankara Universitesi Tip Fakultesi, Ibn-i-Sina Hastanesi

Ankara, 06100, Turkey (Türkiye)

Location

Hacettepe Universitesi Tip Fakultesi

Ankara, 06230, Turkey (Türkiye)

Location

Ankara Universitesi Tip Fakultesi Cebeci Hastanesi

Ankara, 06590, Turkey (Türkiye)

Location

Bezmialem Vakif Universitesi Tip Fakultesi Hastanesi

Istanbul, 34093, Turkey (Türkiye)

Location

Istanbul Universitesi Istanbul Tıp Fakultesi

Istanbul, 34093, Turkey (Türkiye)

Location

Istanbul Universitesi Cerrahpasa Tip Fakultesi

Istanbul, 34098, Turkey (Türkiye)

Location

Erciyes Universitesi Tip Fakultesi

Kayseri, 38039, Turkey (Türkiye)

Location

Kocaeli Universitesi Tip Fakultesi

Kocaeli, 41380, Turkey (Türkiye)

Location

Bulent Ecevit Universitesi Tip Fakultesi

Kozlu Zonguldak, 67600, Turkey (Türkiye)

Location

Mersin Universitesi Tip Fakultesi Hastanesi

Mersin, 33110, Turkey (Türkiye)

Location

Bulent Ecevit Universitesi Tip Fakultesi

Zonguldak, 67600, Turkey (Türkiye)

Location

Regional Consultative Polyclinic

Chernivtsi, 58000, Ukraine

Location

Regional Municipal Institution "Chernivtsi Regional Clinical Hospital", gastroenterology department,

Chernivtsi, 58001, Ukraine

Location

MNCECCH No.2 n.a. PROF O.O. SHALIMOV of KHARKIV CITY COUNCIL

Kharkiv, 61037, Ukraine

Location

Municipal Institution "Kherson City Clinical Hospital n.a. Afanasiy and Olga Tropiny"

Kherson, 73000, Ukraine

Location

Private Enterprise of Private Manufacturing Company "Acinus", Medical and Diagnostic Center

Kropyvnytskyi, 25006, Ukraine

Location

Kyiv Municipal Clinical Hospital #18, Proctology Department

Kyiv, 01030, Ukraine

Location

Medical Center "Universal clinic Oberig" of "Kapital" LLC, Gastro center

Kyiv, 03680, Ukraine

Location

Lviv clinical hospital on Railway Transport of Health Care Center branch of PJSC Ukrainian Railway

Lviv, 79007, Ukraine

Location

Municipal Non-Profit Enterprise "Lviv Clinical Emergency Care Hospital"

Lviv, 79059, Ukraine

Location

Municipal Institution "Odesa Regional Clinical Hospital"

Odesa, 65025, Ukraine

Location

Municipal Institution of Ternopil regional council Ternopil University Hospital

Ternopil, 46002, Ukraine

Location

Municipal Institution "Uzhgorod Regional Hospital"

Uzhhorod, 88009, Ukraine

Location

Zakarpattia Regional Clinical Hospital n.a. A. Novak,

Uzhhorod, 88018, Ukraine

Location

Vinnytsia Regional Clinical Hospital n.a. M.I.Pyrohov

Vinnytsia, 21018, Ukraine

Location

Related Publications (4)

  • Hassan-Zahraee M, Ye Z, Xi L, Dushin E, Lee J, Romatowski J, Leszczyszyn J, Danese S, Sandborn WJ, Banfield C, Gale JD, Peeva E, Longman RS, Hyde CL, Hung KE. Baseline Serum and Stool Microbiome Biomarkers Predict Clinical Efficacy and Tissue Molecular Response After Ritlecitinib Induction Therapy in Ulcerative Colitis. J Crohns Colitis. 2024 Sep 3;18(9):1361-1370. doi: 10.1093/ecco-jcc/jjad213.

  • Wojciechowski J, S Purohit V, Huh Y, Banfield C, Nicholas T. Evolution of Ritlecitinib Population Pharmacokinetic Models During Clinical Drug Development. Clin Pharmacokinet. 2023 Dec;62(12):1765-1779. doi: 10.1007/s40262-023-01318-3. Epub 2023 Nov 2.

  • Sandborn WJ, Danese S, Leszczyszyn J, Romatowski J, Altintas E, Peeva E, Hassan-Zahraee M, Vincent MS, Reddy PS, Banfield C, Salganik M, Banerjee A, Gale JD, Hung KE. Oral Ritlecitinib and Brepocitinib for Moderate-to-Severe Ulcerative Colitis: Results From a Randomized, Phase 2b Study. Clin Gastroenterol Hepatol. 2023 Sep;21(10):2616-2628.e7. doi: 10.1016/j.cgh.2022.12.029. Epub 2023 Jan 6.

  • Fensome A, Ambler CM, Arnold E, Banker ME, Brown MF, Chrencik J, Clark JD, Dowty ME, Efremov IV, Flick A, Gerstenberger BS, Gopalsamy A, Hayward MM, Hegen M, Hollingshead BD, Jussif J, Knafels JD, Limburg DC, Lin D, Lin TH, Pierce BS, Saiah E, Sharma R, Symanowicz PT, Telliez JB, Trujillo JI, Vajdos FF, Vincent F, Wan ZK, Xing L, Yang X, Yang X, Zhang L. Dual Inhibition of TYK2 and JAK1 for the Treatment of Autoimmune Diseases: Discovery of (( S)-2,2-Difluorocyclopropyl)((1 R,5 S)-3-(2-((1-methyl-1 H-pyrazol-4-yl)amino)pyrimidin-4-yl)-3,8-diazabicyclo[3.2.1]octan-8-yl)methanone (PF-06700841). J Med Chem. 2018 Oct 11;61(19):8597-8612. doi: 10.1021/acs.jmedchem.8b00917. Epub 2018 Aug 16.

Related Links

MeSH Terms

Conditions

Colitis, Ulcerative

Interventions

PF-06651600PF-06700841

Condition Hierarchy (Ancestors)

ColitisGastroenteritisGastrointestinal DiseasesDigestive System DiseasesInflammatory Bowel DiseasesColonic DiseasesIntestinal Diseases

Results Point of Contact

Title
Pfizer ClinicalTrials.gov Call Center
Organization
Pfizer Inc.

Study Officials

  • Pfizer CT.gov Call Center

    Pfizer

    STUDY DIRECTOR

Publication Agreements

PI is Sponsor Employee
No
Restriction Type
OTHER
Restrictive Agreement
Yes

Study Design

Study Type
interventional
Phase
phase 2
Allocation
RANDOMIZED
Masking
DOUBLE
Who Masked
PARTICIPANT, INVESTIGATOR
Purpose
TREATMENT
Intervention Model
PARALLEL
Sponsor Type
INDUSTRY
Responsible Party
SPONSOR

Study Record Dates

First Submitted

November 4, 2016

First Posted

November 8, 2016

Study Start

February 3, 2017

Primary Completion

May 10, 2021

Study Completion

May 10, 2021

Last Updated

July 21, 2022

Results First Posted

July 21, 2022

Record last verified: 2022-06

Data Sharing

IPD Sharing
Will share

Pfizer will provide access to individual de-identified participant data and related study documents (e.g. protocol, Statistical Analysis Plan (SAP), Clinical Study Report (CSR)) upon request from qualified researchers, and subject to certain criteria, conditions, and exceptions. Further details on Pfizer's data sharing criteria and process for requesting access can be found at: https://www.pfizer.com/science/clinical\_trials/trial\_data\_and\_results/data\_requests.

More information

Locations