NCT02952677

Brief Summary

This is a multi-centered randomized controlled trial to investigate the effects of "Remind-to-Move" (RTM) using wearable devices at home for promoting upper extremity recovery in stroke patients after discharge from subacute hospitals.

Trial Health

100
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
84

participants targeted

Target at P75+ for not_applicable stroke

Timeline
Completed

Started Nov 2013

Typical duration for not_applicable stroke

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Start

First participant enrolled

November 1, 2013

Completed
2.5 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

May 1, 2016

Completed
1 month until next milestone

Study Completion

Last participant's last visit for all outcomes

June 1, 2016

Completed
3 months until next milestone

First Submitted

Initial submission to the registry

August 31, 2016

Completed
2 months until next milestone

First Posted

Study publicly available on registry

November 2, 2016

Completed
Last Updated

November 2, 2016

Status Verified

August 1, 2016

Enrollment Period

2.5 years

First QC Date

August 31, 2016

Last Update Submit

October 31, 2016

Conditions

Outcome Measures

Primary Outcomes (1)

  • Fugl-Meyer Assessment-Upper Extremity Score

    Hemiplegic arm motor impairment scale

    Change from Baseline to 4-week, plus follow-ups at 8-week and 12-week

Secondary Outcomes (5)

  • Functional Independence Measure

    Change from Baseline to 4-week, plus follow-ups at 8-week and 12-week

  • Motor Activity Log

    Change from 4-week to follow-ups at 8-week and 12-week

  • Accelerometry in wristwatch devices

    Change from Baseline to 4-week

  • Box and Block Test

    Change from Baseline to 4-week, plus follow-ups at 8-week and 12-week

  • Action Research Arm Test

    Change from Baseline to 4-week, and follow-ups at 8-week and 12-week

Study Arms (3)

Experimental

EXPERIMENTAL

Participants receive "Remind-to-move" by means of vibration emitted through sensory cueing wristwatch devices, 3 consecutive hours daily, for 4 weeks, as well as usual care during the intervention period.They are also encouraged to use their arms as much as possible and the accelerometer built-in the device record the arm movement during daily activities.

Behavioral: Remind-to-moveOther: Control

Sham treatment

SHAM COMPARATOR

Participants wear sham wristwatch devices but without vibration cueing, 3 consecutive hours daily, for 4 weeks, as well as usual care during the intervention period. They are also encouraged to use their arms as much as possible and the accelerometer built-in the device record the arm movement during daily activities.

Behavioral: ShamOther: Control

Control

OTHER

Participants receive usual care only during the intervention period.

Other: Control

Interventions

Remind-to-moveBEHAVIORAL

Participants were required to wear sensory cueing wristwatch devices with vibration emitted on the affected arm for 3 consecutive hours daily, for a total of 4 weeks, at any time during the day, and received usual care as well.

Also known as: Sensory cueing
Experimental
ShamBEHAVIORAL

Participants were required to wear sensory cueing wristwatch devices without vibration emitted on the affected arm for 3 consecutive hours daily, for a total of 4 weeks, at any time during the day, and received usual care as well.

Sham treatment
ControlOTHER

Participants received usual care

ControlExperimentalSham treatment

Eligibility Criteria

Age18 Years+
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64), Older Adult (65+)

You may qualify if:

  • Frst-time ischemic or hemorrhagic stroke confirmed by magnetic resonance imaging or X-ray computed tomography
  • Unilateral hemispherical involvement
  • Aged 18 or above
  • Time since onset less than 6 months
  • Functional Test for Hemiplegic Upper Extremity Hong Kong version (FTHUE-HK) ≥ 3 (maximum 7)
  • Able to understand verbal instruction and follow one-step commands
  • Modified Ashworth Scale (MAS) ≤ 2
  • Mini-mental State Examination (MMSE) ≥ 19
  • No complaint of excessive pain or swelling over hemiplegic arm
  • Sensation on the affected wrist intact or with mild impairment only (National Institute of Health Stroke Scale=0 or 1).

You may not qualify if:

  • Participating in any experimental or drug study
  • Unable to give consent to participate
  • Of inadequate balance as indicated by the inability to stand for at least 2 minutes with or without arm support
  • Having history of botulinum toxin injection in 3 months.

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Related Publications (2)

  • Fong KN, Lo PC, Yu YS, Cheuk CK, Tsang TH, Po AS, Chan CC. Effects of sensory cueing on voluntary arm use for patients with chronic stroke: a preliminary study. Arch Phys Med Rehabil. 2011 Jan;92(1):15-23. doi: 10.1016/j.apmr.2010.09.014.

    PMID: 21187201BACKGROUND
  • Fong KN, Yang NY, Chan MK, Chan DY, Lau AF, Chan DY, Cheung JT, Cheung HK, Chung RC, Chan CC. Combined effects of sensory cueing and limb activation on unilateral neglect in subacute left hemiplegic stroke patients: a randomized controlled pilot study. Clin Rehabil. 2013 Jul;27(7):628-37. doi: 10.1177/0269215512471959. Epub 2013 Feb 12.

    PMID: 23405025BACKGROUND

MeSH Terms

Conditions

Stroke

Interventions

salicylhydroxamic acid

Condition Hierarchy (Ancestors)

Cerebrovascular DisordersBrain DiseasesCentral Nervous System DiseasesNervous System DiseasesVascular DiseasesCardiovascular Diseases

Study Officials

  • Kenneth NK Fong, PhD

    The Hong Kong Polytechnic University

    PRINCIPAL INVESTIGATOR

Study Design

Study Type
interventional
Phase
not applicable
Allocation
RANDOMIZED
Masking
SINGLE
Who Masked
OUTCOMES ASSESSOR
Purpose
TREATMENT
Intervention Model
PARALLEL
Sponsor Type
OTHER
Responsible Party
SPONSOR

Study Record Dates

First Submitted

August 31, 2016

First Posted

November 2, 2016

Study Start

November 1, 2013

Primary Completion

May 1, 2016

Study Completion

June 1, 2016

Last Updated

November 2, 2016

Record last verified: 2016-08

Data Sharing

IPD Sharing
Will not share