Improving the Understanding of Catatonia in Autism

NCT02945423 | Withdrawn

• 1 other identifier: HUM00113776
• Study Type: observational
• Target: N/A
• Locations: 0 countries
• Sites: N/A

Brief Summary

Catatonia is a neuropsychiatric syndrome which is frequently missed or misdiagnosed among psychiatric patients. The current project is a systematic examination of catatonia which will characterize the phenotype and identify biological correlates that play a central role in the pathophysiology and effective pharmacological treatment of this condition.

Conditions

Autistic Disorder; Catatonia

Outcome Measures

Primary Outcomes (1)

• Psychiatric, cognitive and biological identification of catatonia in psychiatric illness

  Psychiatric, medical, neuropsychological and biological testing will be completed in approximately 30 subjects and analyzed and reviewed by PI and Co-PIs to determine parameters of catatonia diagnosis in psychiatric patients.

  Three months

Eligibility Criteria

• Age: 10 Years - 30 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Child (0-17), Adult (18-64)
• Sampling Method: Non-Probability Sample

Study Population

Participants will be determined through University of Michigan medical record screening. Participants will be both male and female, between the ages of 10-30 years old (inclusive) and will have a previous diagnosis of catatonia, not secondary to a medical condition.

You may qualify if:

• Age range = 10 to 30 years.
• Already diagnosed with Catatonia during 2005 to 2015.
• Inclusive of current symptoms or have had symptoms in past (symptom

You may not qualify if:

• \. Onset of catatonia is clearly secondary to general medical condition

Sponsors & Collaborators

• University of Michigan: lead

Biospecimen

Retention: SAMPLES WITH DNA

DNA: one 8ml vial of blood will be drawn and stored for future DNA analysis. DNA will be stored as part of the Heinz C. Prechter Genetics Repository.Once the DNA is extracted and genotyped, researchers will sequence the genetic information for specific variants. All samples and data will be de-identified.

MeSH Terms

Conditions

Autistic Disorder; Catatonia

Condition Hierarchy (Ancestors)

Autism Spectrum Disorder; Child Development Disorders, Pervasive; Neurodevelopmental Disorders; Mental Disorders; Neurobehavioral Manifestations; Neurologic Manifestations; Nervous System Diseases; Signs and Symptoms; Pathological Conditions, Signs and Symptoms; Behavioral Symptoms; Behavior

Study Officials

• Neera Ghaziuddin, M.D.

  University of Michigan

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: CASE ONLY
• Time Perspective: CROSS SECTIONAL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Associate Professor

Study Record Dates

• First Submitted: October 20, 2016
• First Posted: October 26, 2016
• Study Start: March 1, 2020
• Primary Completion: October 1, 2021
• Study Completion: October 1, 2023
• Last Updated: April 10, 2020

Record last verified: 2020-04