Carotid Intima-media Thickness as Cardiovascular Mortality Predictor in Peritoneal Dialysis Patients

NCT02938767 | Completed

• 1 other identifier: 3221
• Study Type: observational
• Target: 57
• Locations: 1 country
• Sites: 1

Brief Summary

Cardiovascular (CV) disease is the main cause of death in patients on dialysis. The aim of this study is the long-term prognostic values of carotid intima-media thickness and coronary flow reserve in cardiovascular mortality of peritoneal dialysis patients.

Conditions

Myocardial Infarction

Keywords

peritoneal dialysis; carotid intima-media thickness; coronary flow reserve; cardiovascular mortality

Outcome Measures

Primary Outcomes (1)

• Diseases morbidity

  10-15 years

Secondary Outcomes (1)

• Patient Survival

  10-15 years

Study Arms (2)

peritoneal dialysis patients

37 peritoneal dialysis patients followed at the Istanbul Medical Faculty from October 1994 to October 2011

renal transplant recipients

20 renal transplant recipients followed at the Istanbul Medical Faculty from October 1994 to October 2011 setted as the control group

Eligibility Criteria

• Age: 18 Years - 70 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

All patients were treated by peritoneal dialysis or followed up as kidney transplant recipient at the Istanbul Medical Faculty from October 1994 to October 2011. Two groups were established for trial as peritoneal dialysis patients and renal transplant recipients. Patients had follow up shorter than six months and missing data not included in the trial

You may qualify if:

• Peritoneal dialysis patients whose followed up at least six months from October 1994 to October 2011 (for study group)
• Kidney transplant recipients whose followed up at least six months from October 1994 to October 2011 (for control group)

You may not qualify if:

• diabetes mellitus
• valvular heart disease,
• any prior coronary intervention and congestive heart failure
• Patients whose left anterior descending coronary artery (LAD) could not be visualized adequately by Doppler echocardiography were also excluded.

Sponsors & Collaborators

• Istanbul University: lead

Study Sites (1)

Division of Nephrology, Department of Internal Medicine, Istanbul Faculty of Medicine

Istanbul, 34093, Turkey (Türkiye)

Location

Biospecimen

Retention: SAMPLES WITHOUT DNA

hemogram, serum creatinine, uric asid, calcium, phosphorus and albumin

MeSH Terms

Conditions

Myocardial Infarction

Condition Hierarchy (Ancestors)

Myocardial Ischemia; Heart Diseases; Cardiovascular Diseases; Vascular Diseases; Infarction; Ischemia; Pathologic Processes; Pathological Conditions, Signs and Symptoms; Necrosis

Study Officials

• Yasar Caliskan, MD

  Division of Nephrology, Department of Internal Medicine, Istanbul Faculty of Medicine

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: MD Division of Nephrology, Department of Internal Medicine, Istanbul Faculty of Medicine

Study Record Dates

• First Submitted: October 17, 2016
• First Posted: October 19, 2016
• Study Start: January 1, 2012
• Primary Completion: January 1, 2015
• Study Completion: January 1, 2015
• Last Updated: October 20, 2016

Record last verified: 2016-10

Data Sharing

• IPD Sharing: Will not share

Locations

TU (1)