Prevalence and Long-term Impact of Non-atherosclerotic CAD

NCT01479140 | Completed

• 1 other identifier: H11-03186
• Study Type: observational
• Target: 160
• Locations: 1 country
• Sites: 1

Brief Summary

Despite a relatively high prevalence of non-atherosclerotic coronary artery disease (NACAD) among young women, the majority of these abnormalities were misdiagnosed in this population, and thus treatments were not targeted adequately in this patient population. Furthermore, the short and long-term cardiovascular outcomes of young women with NACAD have not been evaluated. Given the importance of NACAD in young women, the challenges of diagnosis and subsequent treatment, and unknown outcomes with NACAD, we propose a prospective registry to further evaluate this population. We propose to evaluate young women (age \< or equal to 55) presenting with myocardial infarction (MI) prospectively, to diagnose the etiology of MI differentiating atherosclerotic versus NACAD, to correlate the prevalence of FMD in other vascular territory, and to evaluate the long-term outcome of young women with NACAD in comparison to those with atherosclerotic CAD over a 5-year follow-up.

Conditions

Myocardial Infarction

Keywords

myocardial infarction; dissection; coronary Fibromuscular Dysplasia; coronary ectasia; atherosclerotic Coronary Artery Disease; coronary vasculitis; coronary embolism; congenital coronary anomaly

Outcome Measures

Primary Outcomes (3)

• Evaluate the etiology of MI

  To evaluate the etiology of myocardial infarction among young women (age \< or equal to 55) based on angiographic and adjunctive imaging by core laboratory assessment

  5 years

• Evaluate the relative distribution of normal coronary arteries, atherosclerotic, and non-atherosclerotic CAD in this population of young women with MI

  Evaluate the relative distribution of normal coronary arteries, atherosclerotic, and non-atherosclerotic CAD in this population of young women with MI

  5 years

• to screen for the prevalence of SCAD and coronary FMD as the predominant non-atherosclerotic cause for MI in young women

  to screen for the prevalence of SCAD and coronary FMD as the predominant non-atherosclerotic cause for MI in young women

  5 years

Eligibility Criteria

• Age: 19 Years - 55 Years
• Sex: female
• Healthy Volunteers: No
• Age Groups: Adult (18-64)
• Sampling Method: Non-Probability Sample

Study Population

Women aged 55 or younger with a troponin positive acute coronary syndrome (ST and non-ST elevation myocardial infarction or Acute Coronary Syndrome (ACS)) having a coronary angiogram Negative pregnancy test

You may qualify if:

• Women aged 55 or younger with a troponin positive acute coronary syndrome (ST and non-ST elevation myocardial infarction or Acute Coronary Syndrome (ACS)) having a coronary angiogram
• negative pregnancy test for women of child bearing age

You may not qualify if:

• Creatinine clearance \<50
• not willing to undergo an angiogram
• troponin negative ACS

Sponsors & Collaborators

• Cardiology Research UBC: lead
• University of British Columbia: collaborator

Study Sites (1)

Vancouver General Hospital

Vancouver, British Columbia, Canada

Location

MeSH Terms

Conditions

Myocardial Infarction

Condition Hierarchy (Ancestors)

Myocardial Ischemia; Heart Diseases; Cardiovascular Diseases; Vascular Diseases; Infarction; Ischemia; Pathologic Processes; Pathological Conditions, Signs and Symptoms; Necrosis

Study Officials

• Jacqueline Saw, MD

  University of British Columbia

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Principal Investigator, Dr. Jackie Saw

Study Record Dates

• First Submitted: November 22, 2011
• First Posted: November 24, 2011
• Study Start: December 1, 2011
• Primary Completion: January 13, 2021
• Study Completion: January 13, 2021
• Last Updated: January 15, 2021

Record last verified: 2021-01

Locations

CA (1)