The Effect of Isokinetic Strengthening Training

NCT02938416 | Unknown DMC

• 1 other identifier: CF12251
• Study Type: interventional
• Target: 126
• Locations: 1 country
• Sites: 1

Brief Summary

Our participants will include 40 patients within one month of stroke, 43 patients who received total hip replacement or total knee replacement two to four weeks before. The participants will be randomly assigned to isokinetic, isotonic or isometric training groups. Outcome measures including isometric peak torque of hip/knee at 90 degree of flexion, peak torque of hip/knee at angular velocity of 60 degree/s and 120 degree/s, Short Form 36 (SF-36), the Timed Up and Go test, the Oxford Hip/knee Score, the plasma concentration of hsCRP, and the level of substance P in saliva will be collected at the beginning and 4 weeks after the training program. Statistical significant differences will be determined between the improvement of outcome measures of the isokinetic and the isotonic training groups.

Conditions

Resistance Training; Stroke; Arthroplasty, Replacement, Hip; Arthroplasty, Replacement, Knee

Outcome Measures

Primary Outcomes (1)

• Peak torque

  Isometric peak torque of hip/knee at 90 degree of flexion, peak torque of hip/knee at angular velocity of 60 degree/s and 120 degree/s

  4 weeks

Secondary Outcomes (4)

• Timed Up and Go test

  4 weeks

• Short Form 36 (SF-36) questionnaire

  4 weeks

• Oxford Hip/Knee Score

  4 weeks

• The plasma concentration of hsCRP, and the level of substance P in saliva

  4 weeks

Study Arms (3)

Isokinetic training

EXPERIMENTAL

Ten times, three sets of isokinetic strengthening exercise using 30 degree/sec and 120 degree/sec

Device: Isokinetic strengthening exercise

Isotonic training

ACTIVE COMPARATOR

Ten times, three sets of isotonic strengthening exercise using consistent resistance of 60% of 1-repetition maximum of hip or knee

Device: Isotonic strengthening exercise

isometric training

PLACEBO COMPARATOR

home exercise education on isometric quadriceps strengthening on the day of out-patient appointment

Behavioral: isometric strengthening exercise

Interventions

Isokinetic strengthening exercise DEVICE

Isokinetic strengthening exercise provides muscle training throughout the range of motion of a joint at a pre-set constant speed of angular velocity. It can be performed in an eccentric or concentric way in a controlled manner, and is evidenced to be an effective and safe training method in patients with anterior cruciate ligament reconstruction, burn injury, ankle instability, osteoarthritic knee, and chronic stroke in the past literatures.

Isokinetic training

Isotonic strengthening exercise DEVICE

Isotonic strengthening exercise keeps the tension remained unchanged during the muscle's length changing. As the muscle's force changes via the length-tension relationship during a contraction, an isotonic contraction will keep force constant while velocity changes. There are two types of isotonic contractions: (1) concentric and (2) eccentric. In a concentric contraction, the muscle tension rises to meet the resistance, then remains the same as the muscle shortens. In eccentric, the muscle lengthens due to the resistance being greater than the force the muscle is producing.

Isotonic training

isometric strengthening exercise BEHAVIORAL

home exercise education on isometric quadriceps strengthening on the day of out-patient appointment

isometric training

Eligibility Criteria

• Age: 40 Years - 70 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• within one month of acute stroke
• receive total hip/knee replacement within two to four weeks before

You may not qualify if:

• cannot perform from sitting to standing
• Body Mass Index \> 30
• Lower limbs fracture history
• Diabetic polyneuropathy
• Cardiopulmonary diseases that impede exercise prescription
• Impaired cognitive function
• Infectious disease during the study period that may cause cytokine changes

Sponsors & Collaborators

• Taichung Veterans General Hospital: lead

Study Sites (1)

Department of Physical Medicine and Rehabilitation

Taichung, 40705, Taiwan

RECRUITING

Related Publications (2)

• Cheng YY, Chen CH, Wang SP. Isokinetic training of lower extremity during the early stage promote functional restoration in elder patients with disability after Total knee replacement (TKR) - a randomized control trial. BMC Geriatr. 2024 Feb 19;24(1):173. doi: 10.1186/s12877-024-04778-9.

  PMID: 38373934 DERIVED

• Cheng YY, Liu CC, Lin SY, Lee CH, Chang ST, Wang SP. Comparison of the Therapeutic Effects Between Isokinetic and Isotonic Strength Training in Patients After Total Knee Replacement: A Prospective, Randomized Controlled Trial. Orthop J Sports Med. 2022 Jun 21;10(6):23259671221105852. doi: 10.1177/23259671221105852. eCollection 2022 Jun.

  PMID: 35757239 DERIVED

MeSH Terms

Conditions

Stroke

Condition Hierarchy (Ancestors)

Cerebrovascular Disorders; Brain Diseases; Central Nervous System Diseases; Nervous System Diseases; Vascular Diseases; Cardiovascular Diseases

Study Officials

• Yuan-Yang Cheng, MD, PhD

  Department of Physical Medicine and Rehabilitation

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Yuan-Yang Cheng, MD, PhD

CONTACT

+886-4-23592525; rifampin@gmail.com

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: SINGLE
• Who Masked: PARTICIPANT
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Visiting Staff Doctor

Study Record Dates

• First Submitted: October 18, 2016
• First Posted: October 19, 2016
• Study Start: January 1, 2013
• Primary Completion: December 1, 2024
• Study Completion: December 1, 2024
• Last Updated: November 14, 2023

Record last verified: 2023-11

Data Sharing

• IPD Sharing: Will not share

Locations

TW (1)