Buying Time: Improving Sleep to Promote Cognitive Function in Older Adults

NCT02926157 | Completed DMC

• 1 other identifier: H16-01029
• Study Type: interventional
• Target: 96
• Locations: 1 country
• Sites: 1

Brief Summary

The purpose of this study is to investigate whether a comprehensive group education combined with a lifestyle "activation" program that includes (a) sleep hygiene course, (b) physical activity promotion, and (c) bright light therapy, can improve both sleep quality and cognitive function among 96 community-dwelling older adults.

Conditions

Sleep; Aging

Outcome Measures

Primary Outcomes (1)

• Change from baseline in sleep quality as measured by Motion Watch 8 at 3 and 6 months

  Baseline, 3 months, and 6 months

Secondary Outcomes (4)

• Change from baseline in cognitive function as measured by the Alzheimer's Disease Assessment Scale Cognitive Subscale Plus (ADAS-Plus) at 3 and 6 months

  Baseline, 3 months, and 6 months

• Change from baseline in self-reported sleep quality as measured by the Pittsburgh Sleep Quality Index at 3 and 6 months

  Baseline, 3 months, and 6 months

• Change from baseline in physical activity levels as measured by Motion Watch 8 at 3 and 6 months

  Baseline, 3 months, and 6 months

• Change from baseline in self-reported physical activity levels as measured by CHAMPS physical activity questionnaire each month

  Monthly, from baseline through 6 months

Study Arms (2)

Life Style and Sleep Group

EXPERIMENTAL

Participants randomized into this group will undergo a 4 week sleep hygiene course (classes 1x/week for 1.5 hours), followed by a 20 week lifestyle activation program. During the 20 week lifestyle activation program, participants wear a Fit Bit and receive a call from a fitness professional every other week for motivation and recommendations, and receive a bright light therapy program from a sleep expert based on their initial sleep results at the baseline measurement session.

Behavioral: Life Style and Sleep Intervention

Wait-list Control

NO INTERVENTION

Participants randomized into this group will complete all measurement sessions. After completion of the final measurement session (6 months), participants will be offered an abbreviated version of the Life Style and Sleep Group intervention including the sleep hygiene course, consultation with sleep expert to go over individual sleep patterns and be given recommendations, along with physical activity recommendations from a fitness expert.

Interventions

Life Style and Sleep Intervention BEHAVIORAL

Life Style and Sleep Group

Eligibility Criteria

• Age: 65 Years - 85 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Older Adult (65+)

You may qualify if:

• Sleep complaints
• Community-dwelling (not in a long term care facility)
• Read, write, and speak English
• Able to walk independently
• In sufficient health to participate in regular physical activity

You may not qualify if:

• Diagnosis of obstructive sleep apnea
• Receiving continuous positive air pressure (CPAP) treatment
• Diagnosed with dementia of any type
• At high risk for cardiac complications during physical activity or unable to self-regulate activity or understand recommended activity level
• Have a clinically important peripheral neuropathy or sever musculoskeletal or joint disease that impairs mobility

Sponsors & Collaborators

• University of British Columbia: lead

Study Sites (1)

University of British Columbia

Vancouver, British Columbia, V6T 1Z3, Canada

Location

Related Publications (3)

• Balbim GM, Boa Sorte Silva NC, Falck RS, Kramer AF, Voss MW, Liu-Ambrose T. 24-hour activity cycle behaviors and gray matter volume in mild cognitive impairment. Alzheimers Dement. 2025 Jul;21(7):e70496. doi: 10.1002/alz.70496.

  PMID: 40693459 DERIVED

• Falck RS, Davis JC, Best JR, Chan PCY, Li LC, Wyrough AB, Bennett KJ, Backhouse D, Liu-Ambrose T. Effect of a Multimodal Lifestyle Intervention on Sleep and Cognitive Function in Older Adults with Probable Mild Cognitive Impairment and Poor Sleep: A Randomized Clinical Trial. J Alzheimers Dis. 2020;76(1):179-193. doi: 10.3233/JAD-200383.

  PMID: 32444553 DERIVED

• Falck RS, Davis JC, Best JR, Li LC, Chan PCY, Wyrough AB, Landry GJ, Liu-Ambrose T. Buying time: a proof-of-concept randomized controlled trial to improve sleep quality and cognitive function among older adults with mild cognitive impairment. Trials. 2018 Aug 17;19(1):445. doi: 10.1186/s13063-018-2837-7.

  PMID: 30119694 DERIVED

Study Officials

• Teresa Liu-Ambrose, PhD

  University of British Columbia

  PRINCIPAL INVESTIGATOR

• Glenn Landry, PhD

  University of British Columbia

  PRINCIPAL INVESTIGATOR

• Linda Li, PhD

  University of British Columbia

  PRINCIPAL INVESTIGATOR

• Catherine Chan, MPT

  University of British Columbia

  PRINCIPAL INVESTIGATOR

• John Best, PhD

  University of British Columbia

  PRINCIPAL INVESTIGATOR

• Cindy Barha, PhD

  University of British Columbia

  PRINCIPAL INVESTIGATOR

• Jennifer Davis, PhD

  University of British Columbia

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: SINGLE
• Who Masked: OUTCOMES ASSESSOR
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Principal Investigator

Study Record Dates

• First Submitted: September 21, 2016
• First Posted: October 6, 2016
• Study Start: October 1, 2016
• Primary Completion: December 1, 2018
• Study Completion: December 1, 2018
• Last Updated: May 9, 2019

Record last verified: 2019-05

Locations

CA (1)