Choral Singing For the Prevention of Dementia
1 other identifier
interventional
360
1 country
1
Brief Summary
To evaluate the efficacy of choral singing in the prevention of dementia and examine the underlying mechanisms using Magnetic Resonance Imaging (MRI) technique and a panel of peripheral biomarkers in venous blood and urine. The investigators hypothesize that Choral singing could prevent cognitive decline among community-dwelling elderly who are at high risk of dementia. The underlying neural mechanisms involve the changes in brain structure and function that can be quantified using MRI technique. The changes in cognitive outcomes will be accompanied by observable changes from a panel of carefully selected peripheral biomarkers.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P75+ for not_applicable
Started Jul 2015
Longer than P75 for not_applicable
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
Click on a node to explore related trials.
Study Timeline
Key milestones and dates
Study Start
First participant enrolled
July 1, 2015
CompletedFirst Submitted
Initial submission to the registry
September 19, 2016
CompletedFirst Posted
Study publicly available on registry
September 29, 2016
CompletedPrimary Completion
Last participant's last visit for primary outcome
December 1, 2019
CompletedStudy Completion
Last participant's last visit for all outcomes
December 1, 2019
CompletedApril 2, 2018
March 1, 2018
4.4 years
September 19, 2016
March 29, 2018
Conditions
Keywords
Outcome Measures
Primary Outcomes (1)
Changes in cognitive performance
Measured using a composite cognitive test score based on results from a battery of 6 cognitive tests that measures the performance on multiple cognitive domains. The composite cognitive test score (CCTS) will be calculated as the average of Z scores standardised to the baseline mean and standard deviation of trial participants, with higher scores representing better cognitive performance.
Baseline, 1 year, 2 year
Secondary Outcomes (16)
Changes in brain structure and function
Baseline, 1 year, 2 year
Changes in biological markers
Baseline, 1 year, 2 year
Depressive symptoms
Baseline, 6 month, 1 year, 2 year
Anxiety symptoms
Baseline, 6 month, 1 year, 2 year
Stress
Baseline, 6 month, 1 year, 2 year
- +11 more secondary outcomes
Study Arms (2)
Intervention arm
EXPERIMENTALChoral Singing
Control arm
ACTIVE COMPARATORGeneral Health Education Program and Group Activities
Interventions
Weekly session at 1 hour of health education talk and group activities
Eligibility Criteria
You may qualify if:
- Community-living elderly aged 60 years and above, and
- Subjective cognitive complaints based on self-report, or
- Objective cognitive impairment based on neuropsychological test scores (Z score \< 0 and \>-1.5), or
- Multiple risk factors of dementia such as family history, depression, etc., and
- Not demented: Clinical Dementia Rating (CDR) global score=0
You may not qualify if:
- Any terminal illness, OR
- Stroke, OR
- Aphasia, OR
- Marked hearing impairment, OR
- Participating in another interventional study
Contact the study team to confirm eligibility.
Sponsors & Collaborators
- National University of Singaporelead
- Agency for Science, Technology and Researchcollaborator
- Nanyang Technological Universitycollaborator
- University of Cambridgecollaborator
- Ministry of Health, Singaporecollaborator
Study Sites (1)
TaRA@JP
Singapore, 648886, Singapore
Related Publications (5)
Feng L, Ng TP, He Y, Li C, Kua EH, Zhang M. Physical Health and Cognitive Function Independently Contributed to Functional Disability among Chinese Older Adults: Data from Two Asian Metropolises. J Aging Res. 2011;2011:960848. doi: 10.4061/2011/960848. Epub 2011 Sep 14.
PMID: 21941656BACKGROUNDFeng L, Ng XT, Yap P, Li J, Lee TS, Hakansson K, Kua EH, Ng TP. Marital Status and Cognitive Impairment among Community-Dwelling Chinese Older Adults: The Role of Gender and Social Engagement. Dement Geriatr Cogn Dis Extra. 2014 Oct 14;4(3):375-84. doi: 10.1159/000358584. eCollection 2014 Sep.
PMID: 25473404BACKGROUNDWu DX, Feng L, Yao SQ, Tian XF, Mahendran R, Kua EH. The early dementia prevention programme in Singapore. Lancet Psychiatry. 2014 Jun;1(1):9-11. doi: 10.1016/S2215-0366(14)70233-0. Epub 2014 Jun 4. No abstract available.
PMID: 26360390BACKGROUNDNg TKS, Lim ZH, Todd M, Sun F, Ray K, Qi X, Guo J, Ye KX, Maier AB, Mahendran R, Lee Gan G, Tsakok M, Kua EH, Feng L. Effects of choral singing on depression and anxiety in older adults: A randomized controlled trial. J Psychiatr Res. 2025 Aug;188:162-168. doi: 10.1016/j.jpsychires.2025.05.061. Epub 2025 May 26.
PMID: 40449223DERIVEDTan J, Tsakok FHM, Ow EK, Lanskey B, Lim KSD, Goh LG, Tan CH, Cheah IK, Larbi A, Foo R, Loh M, Wong CKY, Suckling J, Li J, Mahendran R, Kua EH, Feng L. Study Protocol for a Randomized Controlled Trial of Choral Singing Intervention to Prevent Cognitive Decline in At-Risk Older Adults Living in the Community. Front Aging Neurosci. 2018 Jul 10;10:195. doi: 10.3389/fnagi.2018.00195. eCollection 2018.
PMID: 30042673DERIVED
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Study Officials
- PRINCIPAL INVESTIGATOR
Lei Feng, Medicine
National University of Singapore
Central Study Contacts
Study Design
- Study Type
- interventional
- Phase
- not applicable
- Allocation
- RANDOMIZED
- Masking
- SINGLE
- Who Masked
- OUTCOMES ASSESSOR
- Purpose
- PREVENTION
- Intervention Model
- PARALLEL
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- Dr
Study Record Dates
First Submitted
September 19, 2016
First Posted
September 29, 2016
Study Start
July 1, 2015
Primary Completion
December 1, 2019
Study Completion
December 1, 2019
Last Updated
April 2, 2018
Record last verified: 2018-03
Data Sharing
- IPD Sharing
- Will not share