Evaluation Report of the Urea / Urine Creatinine as a Marker of Nutritional Status Predictive of ICU Care Associated Infections

NCT02911246 | Completed

• 1 other identifier: RC13_0353
• Study Type: observational
• Target: 309
• Locations: 1 country
• Sites: 1

Brief Summary

Malnutrition is defined by an energy supply deficit, protein, macro-molecules or micro-nutrients, resulting from an imbalance between nutrient intakes and metabolic needs of the body. It concerns 40 to 60% of patients upon entry into resuscitation and influences their prognosis. Studies over the past decade have shown that nutritional deficiency increases the morbidity and mortality in intensive care. Several clinical and biological parameters were evaluated as markers of malnutrition, including the ratio of urea / urine creatinine. The report would identify patients in a state of malnutrition, to optimize their nutritional care. This setting is easy to obtain in all patients by simple urine collection unlike other clinical and biological criteria of resuscitation malnutrition assessment. This ratio of urea / urien creatinine would optimize energy intake of critically ill patients, for which nutritional management methods are widely debated.

Conditions

Brain Injury; Malnutrition

Outcome Measures

Primary Outcomes (1)

• Number of infections related to care during stay in intensive care unit

  Six infections assessed are: 1. Nosocomial pneumonia and tracheobronchitis 2. urinary infection 3. surgical site infection 4. bacteraemia 5. intra-abdominal infection 6. Infection of the central nervous system

  5 days after admission

Eligibility Criteria

• Age: 18 Years - 85 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Patients hospitalized in ICU for severe brain injury

You may qualify if:

• or more
• Admission in ICU
• Estimated length of stay superior to 5 days

You may not qualify if:

• pathologies modifying the ratio of urea / urine creatinine: end stage renal disease ( creatinine clearance less than 15 mL / min), Gastrointestinal bleeding, Right ventricular failure

Sponsors & Collaborators

• Nantes University Hospital: lead

Study Sites (1)

CHU de Nantes

Nantes, 44093, France

Location

MeSH Terms

Conditions

Brain Injuries; Malnutrition

Condition Hierarchy (Ancestors)

Brain Diseases; Central Nervous System Diseases; Nervous System Diseases; Craniocerebral Trauma; Trauma, Nervous System; Wounds and Injuries; Nutrition Disorders; Nutritional and Metabolic Diseases

Study Officials

• Karim Asehnoune, MD PhD

  Nantes University Hospital

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: September 12, 2016
• First Posted: September 22, 2016
• Study Start: December 1, 2014
• Primary Completion: December 1, 2014
• Study Completion: April 1, 2016
• Last Updated: June 24, 2026

Record last verified: 2016-09

Locations

FR (1)