Effects of Viral Reactivation on Outcomes of Brain-injured Patients ( IBIS-VIRUS)
IBIS-VIRUS
1 other identifier
observational
375
1 country
1
Brief Summary
Morbidity and mortality of ICU patients is increased by the development of a "immunosuppression" systemic (IS). This IS develops in the early hours of hospitalization and is responsible for severe infections, including viral reactivations (Cytomegalovirus or Herpes Simplex Virus). Viral reactivation was associated with increased morbidity and mortality in intensive care units. In clinical practice, they are searched at the onset of organ failure or unexplained fever. The investigators wish to conduct this research in the stroke patients to assess the predictive power of these viral reactivations on the duration of mechanical ventilation.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P75+ for all trials
Started Jan 2014
Longer than P75 for all trials
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
First Submitted
Initial submission to the registry
December 2, 2013
CompletedFirst Posted
Study publicly available on registry
December 6, 2013
CompletedStudy Start
First participant enrolled
January 5, 2014
CompletedPrimary Completion
Last participant's last visit for primary outcome
March 26, 2020
CompletedStudy Completion
Last participant's last visit for all outcomes
March 26, 2020
CompletedAugust 25, 2021
August 1, 2021
6.2 years
December 2, 2013
August 24, 2021
Conditions
Keywords
Outcome Measures
Primary Outcomes (1)
Ventilatory-free days at day 90
90 days
Secondary Outcomes (4)
Bacterial hospital acquiered infection
28 days
organ failure
28 days
hospitalisation length of stay
28 days
Mortality
28 days and 90 days
Eligibility Criteria
* Acute brain injury (trauma, subarachnoid haemorrhage, stroke, infection) with Glasgow Coma Scale \<= 12 * Age between 18 and 75 years
You may qualify if:
- Hospitalisation in intensive care unit
- Acute brain injury (trauma, subarachnoid haemorrhage, stroke, infection) with Glasgow Coma Scale \<= 12
- Age between 18 and 75 years
- Mechanical ventilation \> 24 hours
You may not qualify if:
- encephalopathy post anoxy
- active cancer
- Immunosuppresseur treatment
- pregnancy
- history of autoimmune disease
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
CHU de Nantes
Nantes, France
Related Publications (2)
Anani H, Destras G, Regue H, Bulteau S, Bressollette-Bodin C, Roquilly A, Josset L. Metagenome-assembled complete genome of Bohxovirus, a virulent bacteriophage involved in the prediction of hospital-acquired pneumonia in intubated critically ill patients. Microbiol Resour Announc. 2025 Dec 11;14(12):e0059225. doi: 10.1128/mra.00592-25. Epub 2025 Oct 29.
PMID: 41159973DERIVEDAnani H, Destras G, Bulteau S, Castain L, Semanas Q, Burfin G, Petrier M, Martin FP, Poulain C, Dickson RP, Bressollette-Bodin C, Roquilly A, Josset L. Lung virome convergence precedes hospital-acquired pneumonia in intubated critically ill patients. Cell Rep Med. 2025 Sep 16;6(9):102289. doi: 10.1016/j.xcrm.2025.102289. Epub 2025 Sep 5.
PMID: 40914165DERIVED
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Study Officials
- PRINCIPAL INVESTIGATOR
Karim Asehnoune, Pr
Nantes University Hospital
Study Design
- Study Type
- observational
- Observational Model
- COHORT
- Time Perspective
- PROSPECTIVE
- Sponsor Type
- OTHER
- Responsible Party
- SPONSOR
Study Record Dates
First Submitted
December 2, 2013
First Posted
December 6, 2013
Study Start
January 5, 2014
Primary Completion
March 26, 2020
Study Completion
March 26, 2020
Last Updated
August 25, 2021
Record last verified: 2021-08