NCT02899650

Brief Summary

The purpose of this study to determine if older adults who are healthy and physically active (i.e., Masters athletes) demonstrate slower rates of recovery from unaccustomed strenuous exercise of downhill running than younger peers.

Trial Health

57
Monitor

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
60

participants targeted

Target at P25-P50 for not_applicable

Timeline
Completed

Started Aug 2016

Geographic Reach
1 country

1 active site

Status
terminated

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Start

First participant enrolled

August 1, 2016

Completed
1 month until next milestone

First Submitted

Initial submission to the registry

September 2, 2016

Completed
12 days until next milestone

First Posted

Study publicly available on registry

September 14, 2016

Completed
12 months until next milestone

Primary Completion

Last participant's last visit for primary outcome

September 1, 2017

Completed
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

September 1, 2017

Completed
3.4 years until next milestone

Results Posted

Study results publicly available

January 22, 2021

Completed
Last Updated

January 22, 2021

Status Verified

January 1, 2021

Enrollment Period

1.1 years

First QC Date

September 2, 2016

Results QC Date

November 23, 2020

Last Update Submit

January 19, 2021

Conditions

Muscles

Keywords

Delayed Onset Muscle SorenessEccentric exerciseMasters athlete

Outcome Measures

Primary Outcomes (1)

  • Rate of Force Development

    Rate of force development are measured by determining peak torque achieved on an isometric leg extension machine.

    After the downhill running protocol, various markers of muscle damage and muscular strength were obtained 24 hours post (the third visit), 48 hours post (the forth visit) and 72 hours post (the fifth visit).

Secondary Outcomes (1)

  • Pain Scale

    After the downhill running protocol, muscle damage pain scale was measured 24 hours post (the third visit), 48 hours post (the forth visit) and 72 hours post (the fifth visit).

Study Arms (4)

Young Fit

EXPERIMENTAL

Young (18-39 yrs) people who have endurance training habit

Other: exercise

Young Unfit

EXPERIMENTAL

Young (18-39 yrs) people who have sedentary lifestyle.

Other: exercise

Older Fit

EXPERIMENTAL

Older (50-80 yrs) people who have endurance training habit

Other: exercise

Older Unfit

EXPERIMENTAL

Older (50-80 yrs) people who have sedentary lifestyle

Other: exercise

Interventions

exerciseOTHER

acute downhill running

Older FitOlder UnfitYoung FitYoung Unfit

Eligibility Criteria

Age18 Years - 80 Years
Sexall
Healthy VolunteersYes
Age GroupsAdult (18-64), Older Adult (65+)

You may qualify if:

  • Sedentary (exercise \< 1 time/week) or well-trained individuals (exercise ≧ 2 times/week)
  • Ages 18-39 and 50-80 years
  • Individuals who can safely exercise

You may not qualify if:

  • Individuals who reports "Symptoms or Signs Suggestive of Disease" on the Health Research Questionnaire (heart and respiratory problems, dizziness and ankle edema).
  • Individuals who report substance abuse within the last 6 months (elicit drugs, alcohol)
  • Smokers

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Cardiovascular Aging Research Lab at UT Austin

Austin, Texas, 78712, United States

Location

Related Publications (4)

  • Lavender AP, Nosaka K. Changes in markers of muscle damage of middle-aged and young men following eccentric exercise of the elbow flexors. J Sci Med Sport. 2008 Apr;11(2):124-31. doi: 10.1016/j.jsams.2006.11.004. Epub 2007 Mar 9.

    PMID: 17350334BACKGROUND

  • Dedrick ME, Clarkson PM. The effects of eccentric exercise on motor performance in young and older women. Eur J Appl Physiol Occup Physiol. 1990;60(3):183-6. doi: 10.1007/BF00839156.

    PMID: 2347319BACKGROUND

  • Brooks SV, Faulkner JA. Contraction-induced injury: recovery of skeletal muscles in young and old mice. Am J Physiol. 1990 Mar;258(3 Pt 1):C436-42. doi: 10.1152/ajpcell.1990.258.3.C436.

    PMID: 2316632BACKGROUND

  • Brooks SV, Faulkner JA. The magnitude of the initial injury induced by stretches of maximally activated muscle fibres of mice and rats increases in old age. J Physiol. 1996 Dec 1;497 ( Pt 2)(Pt 2):573-80. doi: 10.1113/jphysiol.1996.sp021790.

    PMID: 8961197BACKGROUND

Related Links

MeSH Terms

Interventions

Exercise

Intervention Hierarchy (Ancestors)

Motor ActivityMovementMusculoskeletal Physiological PhenomenaMusculoskeletal and Neural Physiological Phenomena

Results Point of Contact

Title
Koichiro Hayashi
Organization
University of Texas at Austin
k-hayashi@kokugakuin.ac.jp
512-471-8594

Publication Agreements

PI is Sponsor Employee
Yes

Study Design

Study Type
interventional
Phase
not applicable
Allocation
NON RANDOMIZED
Masking
NONE
Purpose
OTHER
Intervention Model
PARALLEL
Sponsor Type
OTHER
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
Professor

Study Record Dates

First Submitted

September 2, 2016

First Posted

September 14, 2016

Study Start

August 1, 2016

Primary Completion

September 1, 2017

Study Completion

September 1, 2017

Last Updated

January 22, 2021

Results First Posted

January 22, 2021

Record last verified: 2021-01

Data Sharing

IPD Sharing
Will not share

Locations

US(1)