Evaluating the Role of Cystatin C and Creatinine as Markers of Renal Recovery in Critically Ill Patients After Acute Kidney Injury.

NCT02894164 | Completed

• 1 other identifier: CysCr1
• Study Type: observational
• Target: 336
• Locations: 1 country
• Sites: 1

Brief Summary

This is a cohort study in which patients who survive Acute Kidney Injury (AKI) during intensive care unit (ICU) admission are recalled at 3-6 months and renal function tests are performed. The purpose of the study is describe renal function in AKI survivors at follow-up. Additional aims are to determine how well admission values of renal function markers perform as predictors of renal function at follow-up and whether estimates of renal function at follow-up differ depending on which renal function marker is used.

Conditions

Acute Kidney Injury; Chronic Kidney Disease; Acute Kidney Disease

Keywords

Cystatin C; Creatinine; Glomerular Filtration Rate

Outcome Measures

Primary Outcomes (1)

• Renal function

  Renal function as defined by estimated glomerular filtration rate (eGFR)using seri Creatinine and Cystatin C at follow-up

  3-9 months

Secondary Outcomes (1)

• Mortality

  2 years

Interventions

No intervention OTHER

Eligibility Criteria

• Age: 18 Years - 100 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Patients admitted to the central intensive care unit at Karolinska University hospital, who suffered from AKI during the period September 2008 until May 2011.

You may qualify if:

• Adults treated on Intensive care with AKI (RIFLE criteria)
• Survival 3 months after discharge.
• Admission during September 2008-May 2011

You may not qualify if:

• Under 18 years
• Unable to give consent.
• Admission during a time when study staff not working.
• Death before 3 month follow-up
• No Swedish personal identification number

Sponsors & Collaborators

• Karolinska Institutet: lead

Study Sites (1)

Karolinska Institute

Stockholm, 171 77, Sweden

Location

Related Publications (1)

• Bellomo R, Ronco C, Kellum JA, Mehta RL, Palevsky P; Acute Dialysis Quality Initiative workgroup. Acute renal failure - definition, outcome measures, animal models, fluid therapy and information technology needs: the Second International Consensus Conference of the Acute Dialysis Quality Initiative (ADQI) Group. Crit Care. 2004 Aug;8(4):R204-12. doi: 10.1186/cc2872. Epub 2004 May 24.

  PMID: 15312219 BACKGROUND

MeSH Terms

Conditions

Acute Kidney Injury; Renal Insufficiency, Chronic

Condition Hierarchy (Ancestors)

Renal Insufficiency; Kidney Diseases; Urologic Diseases; Female Urogenital Diseases; Female Urogenital Diseases and Pregnancy Complications; Urogenital Diseases; Male Urogenital Diseases; Chronic Disease; Disease Attributes; Pathologic Processes; Pathological Conditions, Signs and Symptoms

Study Officials

• Max Bell, PhD

  Karolinska Institutet

  STUDY DIRECTOR

• Johan Mårtensson, PhD

  Karolinska Institutet

  PRINCIPAL INVESTIGATOR

• Claes-Roland Martling, PhD

  Karolinska Institutet

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Target Duration: 2 Years
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Doctor

Study Record Dates

• First Submitted: September 5, 2016
• First Posted: September 9, 2016
• Study Start: January 1, 2008
• Primary Completion: December 1, 2011
• Study Completion: December 1, 2014
• Last Updated: August 23, 2017

Record last verified: 2017-08

Data Sharing

• IPD Sharing: Will not share

Locations

SE (1)