Neural and Cognitive Mechanisms of Depression and Anxiety: a Multimodal MRI Study

NCT02888509 | Unknown DMC

• 1 other identifier: UESTC-chenhuafulab-002
• Study Type: observational
• Target: 150
• Locations: 1 country
• Sites: 1

Brief Summary

To explore the neural and cognitive mechanisms of depression (including unipolar depression and Bipolar disorder) and anxiety using multimodal MRI techniques.

Conditions

Depression

Keywords

depression; anxiety disorder; bipolar disorder; Magnetic Resonance Imaging

Outcome Measures

Primary Outcomes (1)

• Brain structural and functional changes in patients

  Structure and function changes in patients will be assessed by Voxel-based morphometry analysis for structural changes, as well as Regional homogeneity, Amplitude of lowfrequency fluctuation, etc, for functional changes.

  one time point

Study Arms (4)

healthy control

Well mathed with patients in age, gender, education

major depression disorder

patients with major depression disorder

anxiety disorder

patients with anxiety disorder

bipolar depression disorder

patients with bilopar depression disorder

Eligibility Criteria

• Age: 16 Years - 55 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Child (0-17), Adult (18-64)
• Sampling Method: Non-Probability Sample

Study Population

Patients with major depression, bilopar, anxiety disorders were recruited from the mental health center of Chengdu, Sichuan, China.

You may qualify if:

• Age range from 16 to 55 years old.
• All patients were interviewed by two experienced psychiatrists using the Structured Clinical Interview for DSM-IV (patient edition)

You may not qualify if:

• Schizophrenia, mental retardation or personality disorder, any history of loss of consciousness, substance abuse, serious medical or neurological illness.
• Subjects with contraindications to MRI

Sponsors & Collaborators

• University of Electronic Science and Technology of China: lead

Study Sites (1)

School of Life Science and Technology, University of Electronic Science and Technology

Chengdu, Sichuan, 610054, China

RECRUITING

Related Publications (3)

• Chen Y, Cui Q, Sheng W, Tang Q, Lu F, Pang Y, Nan X, He Z, Li D, Lei T, Chen H. Anomalous neurovascular coupling in patients with generalized anxiety disorder evaluated by combining cerebral blood flow and functional connectivity strength. Prog Neuropsychopharmacol Biol Psychiatry. 2021 Dec 20;111:110379. doi: 10.1016/j.pnpbp.2021.110379. Epub 2021 Jun 7.

  PMID: 34111495 DERIVED

• Yang Y, Cui Q, Pang Y, Chen Y, Tang Q, Guo X, Han S, Ameen Fateh A, Lu F, He Z, Huang J, Xie A, Li D, Lei T, Wang Y, Chen H. Frequency-specific alteration of functional connectivity density in bipolar disorder depression. Prog Neuropsychopharmacol Biol Psychiatry. 2021 Jan 10;104:110026. doi: 10.1016/j.pnpbp.2020.110026. Epub 2020 Jul 2.

  PMID: 32621959 DERIVED

• Wang Y, Wang X, Ye L, Yang Q, Cui Q, He Z, Li L, Yang X, Zou Q, Yang P, Liu D, Chen H. Spatial complexity of brain signal is altered in patients with generalized anxiety disorder. J Affect Disord. 2019 Mar 1;246:387-393. doi: 10.1016/j.jad.2018.12.107. Epub 2018 Dec 26.

  PMID: 30597300 DERIVED

MeSH Terms

Conditions

Depression; Anxiety Disorders; Bipolar Disorder

Condition Hierarchy (Ancestors)

Behavioral Symptoms; Behavior; Mental Disorders; Bipolar and Related Disorders; Mood Disorders

Central Study Contacts

Huafu Chen

CONTACT

chenhf@uestc.edu.cn

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: CROSS SECTIONAL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: professor

Study Record Dates

• First Submitted: August 30, 2016
• First Posted: September 5, 2016
• Study Start: June 1, 2015
• Primary Completion: January 1, 2017
• Study Completion: January 1, 2017
• Last Updated: September 5, 2016

Record last verified: 2016-08

Locations

CN (1)