NCT02878811

Brief Summary

The investigators will consecutively recruit 5000 patients hospitalized for heart failure (HF) from 50 hospitals across China and follow them up for one year, describe treatment patterns during hospitalization and the follow-ups, examine patients recovery trajectory after HF, and identify targets for care quality improvement.

Trial Health

43
At Risk

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Trial has exceeded expected completion date
Enrollment
5,000

participants targeted

Target at P75+ for all trials

Timeline
Completed

Started Aug 2016

Typical duration for all trials

Geographic Reach
1 country

1 active site

Status
unknown

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Start

First participant enrolled

August 1, 2016

Completed
15 days until next milestone

First Submitted

Initial submission to the registry

August 16, 2016

Completed
9 days until next milestone

First Posted

Study publicly available on registry

August 25, 2016

Completed
2.8 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

June 1, 2019

Completed
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

June 1, 2019

Completed
Last Updated

December 11, 2017

Status Verified

December 1, 2017

Enrollment Period

2.8 years

First QC Date

August 16, 2016

Last Update Submit

December 8, 2017

Conditions

Heart Failure

Keywords

heart failureprospectivecohort

Outcome Measures

Primary Outcomes (1)

  • Major adverse cardiac events

    Major adverse cardiac events is defined as the composite of cardiovascular death, resuscitated sudden death, HF-related rehospitalization, myocardial infarction, stroke, and incident atrial fibrillation.

    1 year

Secondary Outcomes (13)

  • Death

    1 year

  • Rehospitalization

    1 year

  • Resuscitated sudden death

    1 year

  • Myocardial infarction

    1 year

  • Stroke

    1 year

  • +8 more secondary outcomes

Other Outcomes (6)

  • Length of stay in hospital

    1 year

  • Length of stay in ICU/CCU for index hospitalization

    Duration of hospitalization, average of 10 days

  • Recurrent hospitalizations during study period

    1 year

  • +3 more other outcomes

Interventions

Observational studyOTHER

This is a non-interventional study, patients receive their usual treatment as determined by the physician.

Eligibility Criteria

Age18 Years+
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64), Older Adult (65+)
Sampling MethodNon-Probability Sample
Study Population

Patient with primary reason for admission of heart failure, aged 18 years or above

You may qualify if:

  • Patients with heart failure as the primary reason for hospitalization, including both new-onset HF or decompensation of chronic HF
  • Aged 18 years or above

You may not qualify if:

  • Patients who have enrolled in this study
  • Patients who usually do not live in the city/county where the index hospital locates
  • Patients who are unable to complete interviews due to severe conditions, mental illness, or communication difficulties.

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Xinxiang Central Hospital

Xinxiang, China

RECRUITING

Related Publications (8)

  • Li J, Lei L, Wang W, Li Y, Yu Y, Pu B, Peng Y, Huo X, Zhang L. Patient-reported health status vs . N-terminal pro-B-type natriuretic peptide levels in patients with acute heart failure. Chin Med J (Engl). 2025 Nov 20;138(22):2955-2962. doi: 10.1097/CM9.0000000000003555. Epub 2025 Jul 22.

    PMID: 40693625DERIVED

  • Zhang L, Wang W, Peng Y, He G, Ji R, Lei L, Li J, Pu B, Liu Y, Yu Y, Zhang H. Associations of cumulative depressive symptoms within 1-year of discharge with subsequent mortality among patients hospitalized for acute heart failure: Findings from The China PEACE Prospective Heart Failure Study. J Affect Disord. 2024 Apr 15;351:299-308. doi: 10.1016/j.jad.2024.01.245. Epub 2024 Jan 28.

    PMID: 38290578DERIVED

  • Zhang L, He G, Huo X, Tian A, Ji R, Pu B, Peng Y. Long-Term Cumulative High-Sensitivity C-Reactive Protein and Mortality Among Patients With Acute Heart Failure. J Am Heart Assoc. 2023 Oct 3;12(19):e029386. doi: 10.1161/JAHA.123.029386. Epub 2023 Sep 30.

    PMID: 37776214DERIVED

  • Zhang L, Ji R, He G, Tian A, Huo X, Zheng Y, Qi L, Mi Y, Yan X, Wang B, Lei L, Li J, Liu J, Li J. Individual Trajectories of Health Status During the First Year of Discharge From Hospitalization for Heart Failure and Their Associations With Death in the Following Years. J Am Heart Assoc. 2023 Jul 18;12(14):e028782. doi: 10.1161/JAHA.122.028782. Epub 2023 Jul 8.

    PMID: 37421271DERIVED

  • Wang B, Lei L, Zhang H, Miao F, Zhang L, Tian A, Li J. Change in Depressive Symptoms During the First Month of Discharge and 1-Year Clinical Outcomes in Patients Hospitalized for Heart Failure. J Am Heart Assoc. 2022 Dec 20;11(24):e027438. doi: 10.1161/JAHA.122.027438. Epub 2022 Dec 14.

    PMID: 36515248DERIVED

  • Xing F, Zheng X, Zhang L, Hu S, Bai X, Hu D, Li B, Li J. Discharge heart rate and 1-year clinical outcomes in heart failure patients with atrial fibrillation. Chin Med J (Engl). 2022 Jan 5;135(1):52-62. doi: 10.1097/CM9.0000000000001768.

    PMID: 34982055DERIVED

  • Tian J, Zhao J, Zhang Q, Ren J, Han L, Li J, Zhang Y, Han Q. Assessment of chronic disease self-management in patients with chronic heart failure based on the MCID of patient-reported outcomes by the multilevel model. BMC Cardiovasc Disord. 2021 Jan 30;21(1):58. doi: 10.1186/s12872-021-01872-3.

    PMID: 33516189DERIVED

  • Huang X, Yu Y, Li X, Masoudi FA, Spertus JA, Yan X, Krumholz HM, Jiang L, Li J. The China Patient-centred Evaluative Assessment of Cardiac Events (PEACE) prospective heart failure study design. BMJ Open. 2019 Feb 19;9(2):e025144. doi: 10.1136/bmjopen-2018-025144.

    PMID: 30782925DERIVED

Biospecimen

Retention: SAMPLES WITH DNA

Retention: Samples With DNA Description: the investigators will collect plasma, serum, DNA, RNA, and urine at baseline and during follow-ups.

MeSH Terms

Conditions

Heart Failure

Interventions

Observation

Condition Hierarchy (Ancestors)

Heart DiseasesCardiovascular Diseases

Intervention Hierarchy (Ancestors)

MethodsInvestigative Techniques

Study Officials

  • Jing Li, MD, PhD

    China National Center for Cardiovascular Disease

    PRINCIPAL INVESTIGATOR

  • Harlan M Krumholz, MD, SM

    Yale University

    PRINCIPAL INVESTIGATOR

Central Study Contacts

Jing Li, MD, PhD

CONTACT

+86 (10) 6086 6077jing.li@fwoxford.org

Yuan Yu, MD

CONTACT

+86 17801013954yuan.yu@fwoxford.org

Study Design

Study Type
observational
Observational Model
COHORT
Time Perspective
PROSPECTIVE
Sponsor Type
OTHER GOV
Responsible Party
SPONSOR

Study Record Dates

First Submitted

August 16, 2016

First Posted

August 25, 2016

Study Start

August 1, 2016

Primary Completion

June 1, 2019

Study Completion

June 1, 2019

Last Updated

December 11, 2017

Record last verified: 2017-12

Locations

CN(1)