The Effects of Aerobic Exercise Training on Vascular, Cardiac and Cerebral Vascular Function in COPD

NCT02875522 | Completed

• 1 other identifier: H11-02770
• Study Type: interventional
• Target: 58
• Locations: 1 country
• Sites: 1

Brief Summary

The primary cause of chronic obstructive pulmonary disease is smoking, which can lead to inflammation in the lungs and blood vessels that can lead to secondary problems such as blood vessel disease, high blood pressure and heart disease. Aerobic exercise training has been shown to reduce the risk of heart and brain disease; however, it is currently unknown whether exercise training can have the same affect in patients with COPD. The aim of this study is to investigate how eight weeks of aerobic exercise training improves blood vessel and heart function and brain blood flow in patients with COPD.

Conditions

Chronic Obstructive Pulmonary Disease

Keywords

COPD; Exercise Training; Flow-Mediated Dilation; Arterial Stiffness; Echocardiography; Cerebrovascular Physiology

Outcome Measures

Primary Outcomes (1)

• Endothelial Function

  The change in brachial artery flow mediated dilation measured using reactive hyperaemia

  8-weeks (following 24 sessions of exercise training)

Secondary Outcomes (9)

• Arterial Stiffness

  8-weeks (following 24 sessions of exercise training)

• Carotid intima-medial thickness

  8-weeks (following 24 sessions of exercise training)

• Carotid Compliance

  8-weeks (following 24 sessions of exercise training)

• Inflammatory Biomarkers

  8-weeks (following 24 sessions of exercise training)

• Systolic function

  8-weeks (following 24 sessions of exercise training)

Study Arms (2)

Patients with COPD

EXPERIMENTAL

Stable patients with COPD participated in an 8-week (24 session) individualized, non-linear aerobic exercise training program consisting of upper and lower body cycle ergometry.

Other: Individualized, non-linear aerobic exercise training

Healthy Controls

ACTIVE COMPARATOR

Age, sex, BMI and activity matched controls participated in an 8-week (24 session) individualized, non-linear aerobic exercise training program consisting of upper and lower body cycle ergometry.

Other: Individualized, non-linear aerobic exercise training

Interventions

Individualized, non-linear aerobic exercise training OTHER

Aerobic exercise performed on lower body stationary ergometer and an upper extremity arm crank. Intensity (50-95% workload maximum) and durations (20-45 min) are fluctuated daily to optimize training stress and adaptation

Healthy Controls; Patients with COPD

Eligibility Criteria

• Age: 40 Years - 80 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Non-smokers (\>6 months);
• Forced expiratory volume in one second/ forced vital capacity (FEV1/FVC) \< 0.7 and FEV1/FVC \<lower limit of normal
• Stable (\>3 months exacerbation free)

You may not qualify if:

• On supplemental oxygen;
• Known cardiac or cerebral vascular disease, diabetes, obstructive sleep apnea;
• Uncontrolled hypertension;
• BMI \>30kg/m2
• Currently performing pulmonary rehabilitation or structured exercise training;
• Desaturate during exercise (SpO2\<85%)
• Cardiovascular contraindications to exercise in the incremental test used for screening

Sponsors & Collaborators

• University of British Columbia: lead

Study Sites (1)

University of British Columbia

Kelowna, British Columbia, V1V 1V7, Canada

Location

Related Publications (1)

• Gelinas JC, Lewis NC, Harper MI, Ainslie PN, Rolf JD, Eves ND. Aerobic Exercise Training on Peripheral Vascular Structure and Function in Patients with Chronic Obstructive Pulmonary Disease. American Journal of Respiratory and Critical Care Medicine, 191:A5305, 2015.

  BACKGROUND

MeSH Terms

Conditions

Pulmonary Disease, Chronic Obstructive

Condition Hierarchy (Ancestors)

Lung Diseases, Obstructive; Lung Diseases; Respiratory Tract Diseases; Chronic Disease; Disease Attributes; Pathologic Processes; Pathological Conditions, Signs and Symptoms

Study Officials

• Neil Eves, PhD

  University of British Columbia

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NON RANDOMIZED
• Masking: SINGLE
• Who Masked: OUTCOMES ASSESSOR
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: August 4, 2016
• First Posted: August 23, 2016
• Study Start: January 1, 2012
• Primary Completion: May 1, 2015
• Study Completion: May 1, 2015
• Last Updated: August 23, 2016

Record last verified: 2016-08

Locations

CA (1)